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Vascular responses to compound 48/80 in rat mesenteric vascular beds.
Can J Physiol Pharmacol. 2016 Jun; 94(6):620-6.CJ

Abstract

A further investigation was performed on the vascular effect of endogenous histamine using the histamine releaser, compound 48/80, in rat mesenteric vascular beds with active tone. In preparations with intact endothelium, low concentrations of compound 48/80 (1.53 × 10(-5) - 3 × 1.53 × 10(-5) mg/mL) perfusion for 1 min only induced a small vasodilation. High concentrations of compound 48/80 (1.53 × 10(-4) - 3 × 1.53 × 10(-2) mg/mL) induced a biphasic vascular responses, an initial vasoconstriction followed a subsequent long-lasting vasodilation. The vasodilation induced by low concentrations of compound 48/80 and the vasoconstriction induced by high concentration of compound 48/80 was inhibited by olopatadine. However, cimetidine did not affect the responses induced by compound 48/80. Endothelium removal enlarged the compound 48/80-induced phase-2 vasoconstriction, while it attenuated the phase-3 vasodilation. Additionally, indomethacin and seratrodast significantly inhibited vasoconstriction but it did not affect the long-lasting vasodilation induced by high concentrations of compound 48/80. Ruthenium red inhibited the vasodilation induced by low concentrations and high concentrations of compound 48/80. These results suggest that the vasoconstriction induce by high concentrations of compound 48/80 is mediated by endogenous histamine released from mast cells. It is also suggested that thromboxane A2 released from mast cells is related to the vasoconstriction.

Authors+Show Affiliations

a Department of Pharmacy, Affiliated Hospital of Yanbian University, Yanji 133000, China.b Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.c Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. d Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime 790-8578, Japan.c Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.c Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.c Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.c Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. d Department of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Ehime 790-8578, Japan.b Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26991394

Citation

Jin, Honghua, et al. "Vascular Responses to Compound 48/80 in Rat Mesenteric Vascular Beds." Canadian Journal of Physiology and Pharmacology, vol. 94, no. 6, 2016, pp. 620-6.
Jin H, Li Z, Takatori S, et al. Vascular responses to compound 48/80 in rat mesenteric vascular beds. Can J Physiol Pharmacol. 2016;94(6):620-6.
Jin, H., Li, Z., Takatori, S., Koyama, T., Jin, X., Zamami, Y., Kawasaki, H., & Sun, P. (2016). Vascular responses to compound 48/80 in rat mesenteric vascular beds. Canadian Journal of Physiology and Pharmacology, 94(6), 620-6. https://doi.org/10.1139/cjpp-2015-0442
Jin H, et al. Vascular Responses to Compound 48/80 in Rat Mesenteric Vascular Beds. Can J Physiol Pharmacol. 2016;94(6):620-6. PubMed PMID: 26991394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular responses to compound 48/80 in rat mesenteric vascular beds. AU - Jin,Honghua, AU - Li,Zhen, AU - Takatori,Shingo, AU - Koyama,Toshihiro, AU - Jin,Xin, AU - Zamami,Yoshito, AU - Kawasaki,Hiromu, AU - Sun,Pengyuan, Y1 - 2016/01/15/ PY - 2016/3/19/entrez PY - 2016/3/19/pubmed PY - 2017/2/14/medline KW - artère de résistance mésentérique du rat KW - composé 48/80 KW - compound 48/80 KW - endogenous histamine KW - histamine endogène KW - master cell KW - mastocytes KW - perfusion KW - rat mesenteric resistance artery KW - réponse vasculaire KW - vascular response SP - 620 EP - 6 JF - Canadian journal of physiology and pharmacology JO - Can J Physiol Pharmacol VL - 94 IS - 6 N2 - A further investigation was performed on the vascular effect of endogenous histamine using the histamine releaser, compound 48/80, in rat mesenteric vascular beds with active tone. In preparations with intact endothelium, low concentrations of compound 48/80 (1.53 × 10(-5) - 3 × 1.53 × 10(-5) mg/mL) perfusion for 1 min only induced a small vasodilation. High concentrations of compound 48/80 (1.53 × 10(-4) - 3 × 1.53 × 10(-2) mg/mL) induced a biphasic vascular responses, an initial vasoconstriction followed a subsequent long-lasting vasodilation. The vasodilation induced by low concentrations of compound 48/80 and the vasoconstriction induced by high concentration of compound 48/80 was inhibited by olopatadine. However, cimetidine did not affect the responses induced by compound 48/80. Endothelium removal enlarged the compound 48/80-induced phase-2 vasoconstriction, while it attenuated the phase-3 vasodilation. Additionally, indomethacin and seratrodast significantly inhibited vasoconstriction but it did not affect the long-lasting vasodilation induced by high concentrations of compound 48/80. Ruthenium red inhibited the vasodilation induced by low concentrations and high concentrations of compound 48/80. These results suggest that the vasoconstriction induce by high concentrations of compound 48/80 is mediated by endogenous histamine released from mast cells. It is also suggested that thromboxane A2 released from mast cells is related to the vasoconstriction. SN - 1205-7541 UR - https://www.unboundmedicine.com/medline/citation/26991394/Vascular_responses_to_compound_48/80_in_rat_mesenteric_vascular_beds_ L2 - https://cdnsciencepub.com/doi/10.1139/cjpp-2015-0442?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -