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Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography.
Talanta 2016; 152:392-400T

Abstract

A novel calixarene ionic liquid functionalized silica material was synthesized by the preparation of a new calixarene monomer and its grafting on mercaptopropyl modified silica gel. The material was characterized by infrared spectra, elemental analysis, and thermogravimetric analysis. To explore the retention mechanism of the stationary phase, linear solvation energy relationships (LSER) equation as an effective mathematical model was used. In addition to this, the distinct separation mechanisms were outlined by selected examples of chromatographic separations in the different modes. In reversed-phase liquid chromatography, this new stationary phase presented specific chromatographic performance when evaluated using alkylbenzenes, PAHs and phenols as solutes. Due to the existing polar functional groups, this stationary phase can also be used in hydrophilic interaction chromatography, six nucleosides and four ginsenosides were separated successfully in hydrophilic mode. Furthermore, anions can be separated on the column in anion exchange mode. Thus, this new material was can be applied as a new kind of mixed-mode stationary phase in liquid chromatography, which allows an exceptionally flexible adjustment of retention and selectivity by tuning the experimental conditions.

Authors+Show Affiliations

Henan University of Traditional Chinese Medicine, Zhengzhou 450008, PR China; College of Chemistry and Molecular Engineering, Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, PR China.College of Chemistry and Molecular Engineering, Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, PR China.Henan University of Traditional Chinese Medicine, Zhengzhou 450008, PR China.Henan University of Traditional Chinese Medicine, Zhengzhou 450008, PR China.Henan University of Traditional Chinese Medicine, Zhengzhou 450008, PR China.School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, PR China. Electronic address: wjzhao@126.com.College of Chemistry and Molecular Engineering, Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, PR China.College of Chemistry and Molecular Engineering, Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, PR China. Electronic address: zsszz@126.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26992535

Citation

Hu, Kai, et al. "Calixarene Ionic Liquid Modified Silica Gel: a Novel Stationary Phase for Mixed-mode Chromatography." Talanta, vol. 152, 2016, pp. 392-400.
Hu K, Zhang W, Yang H, et al. Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography. Talanta. 2016;152:392-400.
Hu, K., Zhang, W., Yang, H., Cui, Y., Zhang, J., Zhao, W., ... Zhang, S. (2016). Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography. Talanta, 152, pp. 392-400. doi:10.1016/j.talanta.2016.02.038.
Hu K, et al. Calixarene Ionic Liquid Modified Silica Gel: a Novel Stationary Phase for Mixed-mode Chromatography. Talanta. 2016 May 15;152:392-400. PubMed PMID: 26992535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calixarene ionic liquid modified silica gel: A novel stationary phase for mixed-mode chromatography. AU - Hu,Kai, AU - Zhang,Wenfen, AU - Yang,Huaixia, AU - Cui,Yongxia, AU - Zhang,Jingya, AU - Zhao,Wenjie, AU - Yu,Ajuan, AU - Zhang,Shusheng, Y1 - 2016/02/18/ PY - 2015/12/01/received PY - 2016/02/16/revised PY - 2016/02/17/accepted PY - 2016/3/20/entrez PY - 2016/3/20/pubmed PY - 2016/3/20/medline KW - Calixarene ionic liquid KW - Mixed-mode chromatography KW - Separation mechanism KW - Stationary phase SP - 392 EP - 400 JF - Talanta JO - Talanta VL - 152 N2 - A novel calixarene ionic liquid functionalized silica material was synthesized by the preparation of a new calixarene monomer and its grafting on mercaptopropyl modified silica gel. The material was characterized by infrared spectra, elemental analysis, and thermogravimetric analysis. To explore the retention mechanism of the stationary phase, linear solvation energy relationships (LSER) equation as an effective mathematical model was used. In addition to this, the distinct separation mechanisms were outlined by selected examples of chromatographic separations in the different modes. In reversed-phase liquid chromatography, this new stationary phase presented specific chromatographic performance when evaluated using alkylbenzenes, PAHs and phenols as solutes. Due to the existing polar functional groups, this stationary phase can also be used in hydrophilic interaction chromatography, six nucleosides and four ginsenosides were separated successfully in hydrophilic mode. Furthermore, anions can be separated on the column in anion exchange mode. Thus, this new material was can be applied as a new kind of mixed-mode stationary phase in liquid chromatography, which allows an exceptionally flexible adjustment of retention and selectivity by tuning the experimental conditions. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/26992535/Calixarene_ionic_liquid_modified_silica_gel:_A_novel_stationary_phase_for_mixed_mode_chromatography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(16)30107-2 DB - PRIME DP - Unbound Medicine ER -