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Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats.

Abstract

Alpha-linolenic acid (C18:3 n-3, ALA) is an essential fatty acid and the metabolic precursor of long-chain polyunsaturated fatty acids (LCPUFA) from the n-3 family with relevant physiological and metabolic roles: eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n-3, DHA). Western diet lacks of suitable intake of n-3 LCPUFA and there are recommendations to increase the dietary supply of such nutrients. Seed oils rich in ALA such as those from rosa mosqueta (Rosa rubiginosa), sacha inchi (Plukenetia volubis) and chia (Salvia hispanica) may constitute an alternative that merits research. This study evaluated hepatic and epididymal accretion and biosynthesis of n-3 LCPUFA, the activity and expression of Δ-5 and Δ-6 desaturase enzymes, the expression and DNA-binding activity of PPAR-α and SREBP-1c, oxidative stress parameters and the activity of antioxidative enzymes in rats fed sunflower oil (SFO, 1% ALA) as control group, canola oil (CO, 10% ALA), rosa mosqueta oil (RMO, 33% ALA), sacha inchi oil (SIO, 49% ALA) and chia oil (ChO, 64% ALA) as single lipid source. A larger supply of ALA increased the accretion of n-3 LCPUFA, the activity and expression of desaturases, the antioxidative status, the expression and DNA-binding of PPAR-α, the oxidation of fatty acids and the activity of antioxidant enzymes, whereas the expression and DNA-binding activity of SREBP-1c transcription factor and the biosynthetic activity of fatty acids declined. Results showed that oils rich in ALA such as SIO and ChO may trigger metabolic responses in rats such as those produced by n-3 PUFA.

Authors+Show Affiliations

Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile; Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile. Electronic address: rvalenzuelab@med.uchile.cl.Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.Medical Technology Department, Faculty of Medicine, University of Chile, Santiago, Chile.Nutrition Department, Faculty of Medicine, University of Chile, Santiago, Chile.Lipid Center, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile; Faculty of Medicine, Universidad de Los Andes, Santiago, Chile.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26995676

Citation

Rincón-Cervera, Miguel Ángel, et al. "Vegetable Oils Rich in Alpha Linolenic Acid Increment Hepatic N-3 LCPUFA, Modulating the Fatty Acid Metabolism and Antioxidant Response in Rats." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 111, 2016, pp. 25-35.
Rincón-Cervera MÁ, Valenzuela R, Hernandez-Rodas MC, et al. Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats. Prostaglandins Leukot Essent Fatty Acids. 2016;111:25-35.
Rincón-Cervera, M. Á., Valenzuela, R., Hernandez-Rodas, M. C., Barrera, C., Espinosa, A., Marambio, M., & Valenzuela, A. (2016). Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 111, 25-35. https://doi.org/10.1016/j.plefa.2016.02.002
Rincón-Cervera MÁ, et al. Vegetable Oils Rich in Alpha Linolenic Acid Increment Hepatic N-3 LCPUFA, Modulating the Fatty Acid Metabolism and Antioxidant Response in Rats. Prostaglandins Leukot Essent Fatty Acids. 2016;111:25-35. PubMed PMID: 26995676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats. AU - Rincón-Cervera,Miguel Ángel, AU - Valenzuela,Rodrigo, AU - Hernandez-Rodas,María Catalina, AU - Barrera,Cynthia, AU - Espinosa,Alejandra, AU - Marambio,Macarena, AU - Valenzuela,Alfonso, Y1 - 2016/02/17/ PY - 2016/01/04/received PY - 2016/01/28/revised PY - 2016/02/03/accepted PY - 2016/3/21/entrez PY - 2016/3/21/pubmed PY - 2017/11/29/medline KW - Alpha linolenic acid (ALA) KW - Metabolic and antioxidative responses KW - Vegetable oils rich in ALA KW - n-3 LCPUFA SP - 25 EP - 35 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot. Essent. Fatty Acids VL - 111 N2 - Alpha-linolenic acid (C18:3 n-3, ALA) is an essential fatty acid and the metabolic precursor of long-chain polyunsaturated fatty acids (LCPUFA) from the n-3 family with relevant physiological and metabolic roles: eicosapentaenoic acid (C20:5 n-3, EPA) and docosahexaenoic acid (C22:6 n-3, DHA). Western diet lacks of suitable intake of n-3 LCPUFA and there are recommendations to increase the dietary supply of such nutrients. Seed oils rich in ALA such as those from rosa mosqueta (Rosa rubiginosa), sacha inchi (Plukenetia volubis) and chia (Salvia hispanica) may constitute an alternative that merits research. This study evaluated hepatic and epididymal accretion and biosynthesis of n-3 LCPUFA, the activity and expression of Δ-5 and Δ-6 desaturase enzymes, the expression and DNA-binding activity of PPAR-α and SREBP-1c, oxidative stress parameters and the activity of antioxidative enzymes in rats fed sunflower oil (SFO, 1% ALA) as control group, canola oil (CO, 10% ALA), rosa mosqueta oil (RMO, 33% ALA), sacha inchi oil (SIO, 49% ALA) and chia oil (ChO, 64% ALA) as single lipid source. A larger supply of ALA increased the accretion of n-3 LCPUFA, the activity and expression of desaturases, the antioxidative status, the expression and DNA-binding of PPAR-α, the oxidation of fatty acids and the activity of antioxidant enzymes, whereas the expression and DNA-binding activity of SREBP-1c transcription factor and the biosynthetic activity of fatty acids declined. Results showed that oils rich in ALA such as SIO and ChO may trigger metabolic responses in rats such as those produced by n-3 PUFA. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/26995676/Vegetable_oils_rich_in_alpha_linolenic_acid_increment_hepatic_n_3_LCPUFA_modulating_the_fatty_acid_metabolism_and_antioxidant_response_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(16)30002-3 DB - PRIME DP - Unbound Medicine ER -