Tags

Type your tag names separated by a space and hit enter

Zika virus: History, emergence, biology, and prospects for control.
Antiviral Res 2016; 130:69-80AR

Abstract

Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in Micronesia, the South Pacific, and most recently the Americas. After its putative evolution in sub-Saharan Africa, ZIKV spread in the distant past to Asia and has probably emerged on multiple occasions into urban transmission cycles involving Aedes (Stegomyia) spp. mosquitoes and human amplification hosts, accompanied by a relatively mild dengue-like illness. The unprecedented numbers of people infected during recent outbreaks in the South Pacific and the Americas may have resulted in enough ZIKV infections to notice relatively rare congenital microcephaly and Guillain-Barré syndromes. Another hypothesis is that phenotypic changes in Asian lineage ZIKV strains led to these disease outcomes. Here, we review potential strategies to control the ongoing outbreak through vector-centric approaches as well as the prospects for the development of vaccines and therapeutics.

Authors+Show Affiliations

Institute for Human Infections and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston TX, USA; Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston TX, USA. Electronic address: sweaver@utmb.edu.Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil; Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Ministério da Saúde, Salvador, BA, Brazil; Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry & Molecular Biology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology & Toxicology, and Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA.Institute for Human Infections and Immunity, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston TX, USA; Institute for Human Infections and Immunity, Department of Pathology, University of Texas Medical Branch, Galveston TX, USA.

Pub Type(s)

Historical Article
Journal Article
Review
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26996139

Citation

Weaver, Scott C., et al. "Zika Virus: History, Emergence, Biology, and Prospects for Control." Antiviral Research, vol. 130, 2016, pp. 69-80.
Weaver SC, Costa F, Garcia-Blanco MA, et al. Zika virus: History, emergence, biology, and prospects for control. Antiviral Res. 2016;130:69-80.
Weaver, S. C., Costa, F., Garcia-Blanco, M. A., Ko, A. I., Ribeiro, G. S., Saade, G., ... Vasilakis, N. (2016). Zika virus: History, emergence, biology, and prospects for control. Antiviral Research, 130, pp. 69-80. doi:10.1016/j.antiviral.2016.03.010.
Weaver SC, et al. Zika Virus: History, Emergence, Biology, and Prospects for Control. Antiviral Res. 2016;130:69-80. PubMed PMID: 26996139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zika virus: History, emergence, biology, and prospects for control. AU - Weaver,Scott C, AU - Costa,Federico, AU - Garcia-Blanco,Mariano A, AU - Ko,Albert I, AU - Ribeiro,Guilherme S, AU - Saade,George, AU - Shi,Pei-Yong, AU - Vasilakis,Nikos, Y1 - 2016/03/18/ PY - 2016/02/29/received PY - 2016/03/09/revised PY - 2016/03/12/accepted PY - 2016/3/22/entrez PY - 2016/3/22/pubmed PY - 2017/11/29/medline SP - 69 EP - 80 JF - Antiviral research JO - Antiviral Res. VL - 130 N2 - Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series of epidemics in Micronesia, the South Pacific, and most recently the Americas. After its putative evolution in sub-Saharan Africa, ZIKV spread in the distant past to Asia and has probably emerged on multiple occasions into urban transmission cycles involving Aedes (Stegomyia) spp. mosquitoes and human amplification hosts, accompanied by a relatively mild dengue-like illness. The unprecedented numbers of people infected during recent outbreaks in the South Pacific and the Americas may have resulted in enough ZIKV infections to notice relatively rare congenital microcephaly and Guillain-Barré syndromes. Another hypothesis is that phenotypic changes in Asian lineage ZIKV strains led to these disease outcomes. Here, we review potential strategies to control the ongoing outbreak through vector-centric approaches as well as the prospects for the development of vaccines and therapeutics. SN - 1872-9096 UR - https://www.unboundmedicine.com/medline/citation/26996139/Zika_virus:_History_emergence_biology_and_prospects_for_control_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-3542(16)30120-6 DB - PRIME DP - Unbound Medicine ER -