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Outcome after hydrogen sulphide intoxication.
Resuscitation 2016; 103:1-6R

Abstract

AIM

Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published.

METHODS

The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described.

RESULTS

From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min.

CONCLUSION

Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible.

Authors+Show Affiliations

Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Mobile Medical Team, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Mobile Medical Team, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Intensive Care Medicine and National Poison Information Center (NPIC), University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.Surgical Research Laboratory, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: w.m.van.den.bergh@umcg.nl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26997477

Citation

Mooyaart, Eline A Q., et al. "Outcome After Hydrogen Sulphide Intoxication." Resuscitation, vol. 103, 2016, pp. 1-6.
Mooyaart EAQ, Gelderman ELG, Nijsten MW, et al. Outcome after hydrogen sulphide intoxication. Resuscitation. 2016;103:1-6.
Mooyaart, E. A. Q., Gelderman, E. L. G., Nijsten, M. W., de Vos, R., Hirner, J. M., de Lange, D. W., ... van den Bergh, W. M. (2016). Outcome after hydrogen sulphide intoxication. Resuscitation, 103, pp. 1-6. doi:10.1016/j.resuscitation.2016.03.012.
Mooyaart EAQ, et al. Outcome After Hydrogen Sulphide Intoxication. Resuscitation. 2016;103:1-6. PubMed PMID: 26997477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome after hydrogen sulphide intoxication. AU - Mooyaart,Eline A Q, AU - Gelderman,Egbert L G, AU - Nijsten,Maarten W, AU - de Vos,Ronald, AU - Hirner,J Manfred, AU - de Lange,Dylan W, AU - Leuvenink,Henri D G, AU - van den Bergh,Walter M, Y1 - 2016/03/18/ PY - 2015/12/22/received PY - 2016/02/19/revised PY - 2016/03/09/accepted PY - 2016/3/22/entrez PY - 2016/3/22/pubmed PY - 2017/10/24/medline KW - Gasotransmitter KW - Hibernation KW - Hydrogen sulfide intoxication KW - Hydrogen sulphide KW - Hypometabolism KW - Out-of-hospital cardiac arrest SP - 1 EP - 6 JF - Resuscitation JO - Resuscitation VL - 103 N2 - AIM: Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published. METHODS: The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described. RESULTS: From 1980 until 2013, 35 accidents totalling 56 victims occurred of whom at least 24 (43%) survived. Of the 8 patients with documented cardiopulmonary resuscitation on the scene, 6 (75%) survived. In some of these cases with good outcome the exposure time to very high hydrogen sulphide levels before extraction and resuscitation was more than 45min. CONCLUSION: Manure related hydrogen sulphide intoxication is associated with a high mortality, although in some cases, recovery appears to be far more favourable than the initial presentation would suggest. Possibly protection from hypoxic injury due to induction of a suspended animation-like state by hydrogen sulphide may be responsible. SN - 1873-1570 UR - https://www.unboundmedicine.com/medline/citation/26997477/Outcome_after_hydrogen_sulphide_intoxication L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-9572(16)00129-5 DB - PRIME DP - Unbound Medicine ER -