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Giant viruses come of age.
Curr Opin Microbiol. 2016 06; 31:50-57.CO

Abstract

Viruses with genomes up to a few megabases in length are a common occurrence in nature, even though they have escaped our notice until recently. These giant viruses infect mainly single-celled eukaryotes and isolation efforts concentrating on amoebal hosts alone have spawned hundreds of viral isolates, featuring viruses with previously unseen virion morphologies and the largest known viral genomes and particles. One of the challenges that lie ahead is to analyze and categorize the available data and to establish an approved classification system that reflects the evolutionary relationships and biological properties of these viruses. Extensive sampling of Acanthamoeba-infecting mimiviruses and initial characterization of their virophage parasites have provided a first blueprint of the genetic diversity and composition of a giant virus clade that will facilitate the taxonomic grouping of these fascinating microorganisms.

Authors+Show Affiliations

Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany. Electronic address: mfischer@mpimf-heidelberg.mpg.de.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26999382

Citation

Fischer, Matthias G.. "Giant Viruses Come of Age." Current Opinion in Microbiology, vol. 31, 2016, pp. 50-57.
Fischer MG. Giant viruses come of age. Curr Opin Microbiol. 2016;31:50-57.
Fischer, M. G. (2016). Giant viruses come of age. Current Opinion in Microbiology, 31, 50-57. https://doi.org/10.1016/j.mib.2016.03.001
Fischer MG. Giant Viruses Come of Age. Curr Opin Microbiol. 2016;31:50-57. PubMed PMID: 26999382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Giant viruses come of age. A1 - Fischer,Matthias G, Y1 - 2016/03/19/ PY - 2016/01/22/received PY - 2016/03/04/revised PY - 2016/03/07/accepted PY - 2016/3/22/entrez PY - 2016/3/22/pubmed PY - 2017/11/29/medline SP - 50 EP - 57 JF - Current opinion in microbiology JO - Curr Opin Microbiol VL - 31 N2 - Viruses with genomes up to a few megabases in length are a common occurrence in nature, even though they have escaped our notice until recently. These giant viruses infect mainly single-celled eukaryotes and isolation efforts concentrating on amoebal hosts alone have spawned hundreds of viral isolates, featuring viruses with previously unseen virion morphologies and the largest known viral genomes and particles. One of the challenges that lie ahead is to analyze and categorize the available data and to establish an approved classification system that reflects the evolutionary relationships and biological properties of these viruses. Extensive sampling of Acanthamoeba-infecting mimiviruses and initial characterization of their virophage parasites have provided a first blueprint of the genetic diversity and composition of a giant virus clade that will facilitate the taxonomic grouping of these fascinating microorganisms. SN - 1879-0364 UR - https://www.unboundmedicine.com/medline/citation/26999382/Giant_viruses_come_of_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1369-5274(16)30008-X DB - PRIME DP - Unbound Medicine ER -