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Strategies for calibrating a subcutaneous glucose sensor.
Biomed Biochim Acta. 1989; 48(11-12):957-64.BB

Abstract

The calibration of the glucose sensor is a critical issue for the subcutaneous implantation of such devices, since it allows from the sensor output the estimation of the prevailing subcutaneous glucose concentration. This study has compared estimations of subcutaneous glucose concentration in rats, calculated from the sensor's signal by using calibration parameters (sensitivity coefficient and background current) determined either under in vitro or in vivo conditions. The in vitro calibration was performed in phosphate buffer at 37 degrees C. The in vivo parameters were calculated by comparing changes in the sensor output current to concomitant changes in blood glucose concentration, induced by intravenous insulin injection and glucose infusion. The apparent subcutaneous glucose concentration, calculated with in vitro parameters, remained much lower than the concomitant blood glucose levels throughout the experiments. By contrast, when it was calculated with the calibration parameters determined in vivo, either in the hypoglycemia or hyperglycemia range, the apparent subcutaneous glucose concentration well reflected blood glucose levels with a five min time lag. We conclude that it is the two-point in vivo calibration procedure which allows the calculation of an apparent subcutaneous glucose concentration best reflecting blood glucose levels.

Authors+Show Affiliations

Service de Diabétologie, Hôtel-Dieu, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2700068

Citation

Velho, G, et al. "Strategies for Calibrating a Subcutaneous Glucose Sensor." Biomedica Biochimica Acta, vol. 48, no. 11-12, 1989, pp. 957-64.
Velho G, Froguel P, Thevenot DR, et al. Strategies for calibrating a subcutaneous glucose sensor. Biomed Biochim Acta. 1989;48(11-12):957-64.
Velho, G., Froguel, P., Thevenot, D. R., & Reach, G. (1989). Strategies for calibrating a subcutaneous glucose sensor. Biomedica Biochimica Acta, 48(11-12), 957-64.
Velho G, et al. Strategies for Calibrating a Subcutaneous Glucose Sensor. Biomed Biochim Acta. 1989;48(11-12):957-64. PubMed PMID: 2700068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strategies for calibrating a subcutaneous glucose sensor. AU - Velho,G, AU - Froguel,P, AU - Thevenot,D R, AU - Reach,G, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 957 EP - 64 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 48 IS - 11-12 N2 - The calibration of the glucose sensor is a critical issue for the subcutaneous implantation of such devices, since it allows from the sensor output the estimation of the prevailing subcutaneous glucose concentration. This study has compared estimations of subcutaneous glucose concentration in rats, calculated from the sensor's signal by using calibration parameters (sensitivity coefficient and background current) determined either under in vitro or in vivo conditions. The in vitro calibration was performed in phosphate buffer at 37 degrees C. The in vivo parameters were calculated by comparing changes in the sensor output current to concomitant changes in blood glucose concentration, induced by intravenous insulin injection and glucose infusion. The apparent subcutaneous glucose concentration, calculated with in vitro parameters, remained much lower than the concomitant blood glucose levels throughout the experiments. By contrast, when it was calculated with the calibration parameters determined in vivo, either in the hypoglycemia or hyperglycemia range, the apparent subcutaneous glucose concentration well reflected blood glucose levels with a five min time lag. We conclude that it is the two-point in vivo calibration procedure which allows the calculation of an apparent subcutaneous glucose concentration best reflecting blood glucose levels. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/2700068/Strategies_for_calibrating_a_subcutaneous_glucose_sensor_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -