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The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity.
Int Clin Psychopharmacol. 2016 07; 31(4):232-9.IC

Abstract

The aim of this observational study was to assess the efficacy of a tetrahydrocannabinol-cannabidiol (THC : CBD) oromucosal spray on spasticity using the stretch reflex in patients with multiple sclerosis (MS). Numeric rating scale (NRS) for spasticity, modified Ashworth scale (MAS), and the stretch reflex were assessed before and during treatment in 57 MS patients with spasticity eligible for THC : CBD treatment. A significant reduction in stretch reflex amplitude as well as significant reductions of NRS and MAS scores were observed. There was a low concordance between the three measures (stretch reflex, NRS, and MAS), likely related to the different aspects of muscle hypertonia assessed. Stretch reflex responders were taking a significantly higher number of puffs, whereas no differences were found in the responders by the other scales, suggesting that a higher dosage would add benefit if tolerated. The present study confirms the efficacy of cannabinoids in reducing spasticity in patients with MS, suggesting a higher sensitivity and specificity of the stretch reflex compared with other measures. As an objective and quantitative measure of spasticity, the stretch reflex is particularly useful to assess the effects of cannabinoids on spinal excitability and may play a role in future pharmacological studies.

Authors+Show Affiliations

aDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Institute of Neurology, University of Genova, Genova bAcademic Neurology Unit, A. Fiorini Hospital, Terracina cDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino dNeurology Unit, Policlinico Umberto I, Department of Neurology and Psychiatry, Sapienza University of Rome, Rome eDepartment of Neurology, San Paolo Hospital, Savona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

27003093

Citation

Marinelli, Lucio, et al. "The Effect of Cannabinoids On the Stretch Reflex in Multiple Sclerosis Spasticity." International Clinical Psychopharmacology, vol. 31, no. 4, 2016, pp. 232-9.
Marinelli L, Mori L, Canneva S, et al. The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. Int Clin Psychopharmacol. 2016;31(4):232-9.
Marinelli, L., Mori, L., Canneva, S., Colombano, F., Currà, A., Fattapposta, F., Bandini, F., Capello, E., Abbruzzese, G., & Trompetto, C. (2016). The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. International Clinical Psychopharmacology, 31(4), 232-9. https://doi.org/10.1097/YIC.0000000000000126
Marinelli L, et al. The Effect of Cannabinoids On the Stretch Reflex in Multiple Sclerosis Spasticity. Int Clin Psychopharmacol. 2016;31(4):232-9. PubMed PMID: 27003093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. AU - Marinelli,Lucio, AU - Mori,Laura, AU - Canneva,Stefania, AU - Colombano,Federica, AU - Currà,Antonio, AU - Fattapposta,Francesco, AU - Bandini,Fabio, AU - Capello,Elisabetta, AU - Abbruzzese,Giovanni, AU - Trompetto,Carlo, PY - 2016/3/23/entrez PY - 2016/3/24/pubmed PY - 2017/11/29/medline SP - 232 EP - 9 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 31 IS - 4 N2 - The aim of this observational study was to assess the efficacy of a tetrahydrocannabinol-cannabidiol (THC : CBD) oromucosal spray on spasticity using the stretch reflex in patients with multiple sclerosis (MS). Numeric rating scale (NRS) for spasticity, modified Ashworth scale (MAS), and the stretch reflex were assessed before and during treatment in 57 MS patients with spasticity eligible for THC : CBD treatment. A significant reduction in stretch reflex amplitude as well as significant reductions of NRS and MAS scores were observed. There was a low concordance between the three measures (stretch reflex, NRS, and MAS), likely related to the different aspects of muscle hypertonia assessed. Stretch reflex responders were taking a significantly higher number of puffs, whereas no differences were found in the responders by the other scales, suggesting that a higher dosage would add benefit if tolerated. The present study confirms the efficacy of cannabinoids in reducing spasticity in patients with MS, suggesting a higher sensitivity and specificity of the stretch reflex compared with other measures. As an objective and quantitative measure of spasticity, the stretch reflex is particularly useful to assess the effects of cannabinoids on spinal excitability and may play a role in future pharmacological studies. SN - 1473-5857 UR - https://www.unboundmedicine.com/medline/citation/27003093/The_effect_of_cannabinoids_on_the_stretch_reflex_in_multiple_sclerosis_spasticity_ L2 - https://doi.org/10.1097/YIC.0000000000000126 DB - PRIME DP - Unbound Medicine ER -