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Homocysteinemia is Associated with a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era.
Nutr Cancer 2016; 68(3):446-55NC

Abstract

The primary aim of the study was to determine whether plasma concentrations of homocysteine (Hcy), a functional indicator of methyl donor nutrients, are associated with altered risk of higher grades of cervical intraepithelial neoplasia (CIN 2+) and the degree of methylation in long interspersed nucleotide elements (LINE-1s) of peripheral blood mononuclear cells, a potential biomarker of CIN 2+ in a population of women exposed to the United States folic acid fortification program. The secondary aim was to assess the determinants of plasma Hcy in the same population. The study included 457 women diagnosed with either CIN 2+ (cases, n = 132) or ≤ CIN 1 (non-cases, n = 325). Unconditional logistic regression models were used to test the associations after adjusting for relevant risk factors of cervical cancer. Women with higher Hcy concentrations were at a greater risk of being diagnosed with CIN 2+ [odds ratio (OR) = 1.86, P = 0.005]. Higher plasma folate concentrations were a significant determinant of lower Hcy (OR = 0.40, P = 0.0002). Women with higher Hcy concentrations were more likely to have a lower degree of LINE-1 methylation (OR = 2.30, P = 0.0007). These results suggested that further improvement in folate status in this population may be beneficial for lowering Hcy and improving the degree of LINE-1 methylation.

Authors+Show Affiliations

a Department of Nutrition Sciences , University of Alabama at Birmingham , Birmingham , Alabama , USA.a Department of Nutrition Sciences , University of Alabama at Birmingham , Birmingham , Alabama , USA.b Department of Pediatrics , Division of Biostatistics and Epidemiology, The University of Cincinnati College of Medicine , Cincinnati , Ohio , USA.c Biosciences Division, Center for Cancer and Metabolism, SRI International , Menlo Park , California , USA.a Department of Nutrition Sciences , University of Alabama at Birmingham , Birmingham , Alabama , USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27008272

Citation

Badiga, Suguna, et al. "Homocysteinemia Is Associated With a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era." Nutrition and Cancer, vol. 68, no. 3, 2016, pp. 446-55.
Badiga S, Siddiqui NR, Macaluso M, et al. Homocysteinemia is Associated with a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era. Nutr Cancer. 2016;68(3):446-55.
Badiga, S., Siddiqui, N. R., Macaluso, M., Johanning, G. L., & Piyathilake, C. J. (2016). Homocysteinemia is Associated with a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era. Nutrition and Cancer, 68(3), pp. 446-55. doi:10.1080/01635581.2016.1152388.
Badiga S, et al. Homocysteinemia Is Associated With a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era. Nutr Cancer. 2016;68(3):446-55. PubMed PMID: 27008272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteinemia is Associated with a Lower Degree of PBMC LINE-1 Methylation and a Higher Risk of CIN 2C in the U.S. Post-Folic Acid Fortification Era. AU - Badiga,Suguna, AU - Siddiqui,Nuzhat R, AU - Macaluso,Maurizio, AU - Johanning,Gary L, AU - Piyathilake,Chandrika J, Y1 - 2016/03/23/ PY - 2016/3/24/entrez PY - 2016/3/24/pubmed PY - 2017/1/14/medline SP - 446 EP - 55 JF - Nutrition and cancer JO - Nutr Cancer VL - 68 IS - 3 N2 - The primary aim of the study was to determine whether plasma concentrations of homocysteine (Hcy), a functional indicator of methyl donor nutrients, are associated with altered risk of higher grades of cervical intraepithelial neoplasia (CIN 2+) and the degree of methylation in long interspersed nucleotide elements (LINE-1s) of peripheral blood mononuclear cells, a potential biomarker of CIN 2+ in a population of women exposed to the United States folic acid fortification program. The secondary aim was to assess the determinants of plasma Hcy in the same population. The study included 457 women diagnosed with either CIN 2+ (cases, n = 132) or ≤ CIN 1 (non-cases, n = 325). Unconditional logistic regression models were used to test the associations after adjusting for relevant risk factors of cervical cancer. Women with higher Hcy concentrations were at a greater risk of being diagnosed with CIN 2+ [odds ratio (OR) = 1.86, P = 0.005]. Higher plasma folate concentrations were a significant determinant of lower Hcy (OR = 0.40, P = 0.0002). Women with higher Hcy concentrations were more likely to have a lower degree of LINE-1 methylation (OR = 2.30, P = 0.0007). These results suggested that further improvement in folate status in this population may be beneficial for lowering Hcy and improving the degree of LINE-1 methylation. SN - 1532-7914 UR - https://www.unboundmedicine.com/medline/citation/27008272/Homocysteinemia_is_Associated_with_a_Lower_Degree_of_PBMC_LINE_1_Methylation_and_a_Higher_Risk_of_CIN_2C_in_the_U_S__Post_Folic_Acid_Fortification_Era_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635581.2016.1152388 DB - PRIME DP - Unbound Medicine ER -