Tags

Type your tag names separated by a space and hit enter

The effect of fish oil supplementation on serum phospholipid fatty acids profile during pregnancy: A double blind randomized controlled trial.
Women Health 2017; 57(2):137-153WH

Abstract

Omega-3 fatty acids (FAs) are essential unsaturated long-chain FAs necessary for proper health and growth. The objective of the authors in this study was to evaluate the effect of fish oil supplementation in pregnancy on maternal serum FA profiles. Participants (n = 150 pregnant women aged 18-35 years in Tabriz, Iran) were randomly assigned to receive either 1,000 mg fish oil supplements daily containing 120 mg docosahexanoic acid (DHA) and 180 mg eicosapentaenoic acid (EPA), or placebo from week 21 of pregnancy to delivery. The primary outcome measures were mean serum DHA and EPA proportion of total FAs at weeks 35-37 of pregnancy. Analyses were based on intention-to-treat. No significant differences were observed between the groups in consumption of fish and serum FAs levels at baseline. Fish oil supplementation significantly increased the mean DHA proportion of total FAs in the intervention compared to the placebo group at weeks 35-37 [adjusted Mean Difference (aMD) = 0.15; 95% CI 0.08-0.23]. The mean EPA proportion of total FAs also increased in the intervention group, but the difference between the groups was not significant (aMD = 0.04; 95% CI -0.01 to 0.08). The dietary recommendation for consumption of 1,000 mg/day fish oil supplements during pregnancy seems beneficial for better serum FA composition.

Authors+Show Affiliations

a Tabriz Health Services Management Research Center , Tabriz University of Medical Sciences , Tabriz , Iran. b Department of Midwifery, Faculty of Nursing and Midwifery , Tabriz University of Medical Sciences , Tabriz , Iran.b Department of Midwifery, Faculty of Nursing and Midwifery , Tabriz University of Medical Sciences , Tabriz , Iran. c Research Center of Social Determinants of Health , Tabriz University of Medical Sciences , Tabriz , Iran.d Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran. e Department of Biochemistry and Clinical Laboratories , School of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.f Department of Medical Science, Tabriz Branch , Islamic Azad University , Tabriz , Iran.g Liver and Gastrointestinal Disease Research Center , Tabriz University of Medical Sciences , Tabriz , Iran. h Stem Cell Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.e Department of Biochemistry and Clinical Laboratories , School of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.a Tabriz Health Services Management Research Center , Tabriz University of Medical Sciences , Tabriz , Iran. i Nutrition Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27011294

Citation

Farshbaf-Khalili, Azizeh, et al. "The Effect of Fish Oil Supplementation On Serum Phospholipid Fatty Acids Profile During Pregnancy: a Double Blind Randomized Controlled Trial." Women & Health, vol. 57, no. 2, 2017, pp. 137-153.
Farshbaf-Khalili A, Mohamad-Alizadeh S, Darabi M, et al. The effect of fish oil supplementation on serum phospholipid fatty acids profile during pregnancy: A double blind randomized controlled trial. Women Health. 2017;57(2):137-153.
Farshbaf-Khalili, A., Mohamad-Alizadeh, S., Darabi, M., Hematzadeh, S., Mehdizadeh, A., Shaaker, M., & Ostadrahimi, A. (2017). The effect of fish oil supplementation on serum phospholipid fatty acids profile during pregnancy: A double blind randomized controlled trial. Women & Health, 57(2), pp. 137-153. doi:10.1080/03630242.2016.1159269.
Farshbaf-Khalili A, et al. The Effect of Fish Oil Supplementation On Serum Phospholipid Fatty Acids Profile During Pregnancy: a Double Blind Randomized Controlled Trial. Women Health. 2017;57(2):137-153. PubMed PMID: 27011294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of fish oil supplementation on serum phospholipid fatty acids profile during pregnancy: A double blind randomized controlled trial. AU - Farshbaf-Khalili,Azizeh, AU - Mohamad-Alizadeh,Sakineh, AU - Darabi,Masoud, AU - Hematzadeh,Shahla, AU - Mehdizadeh,Amir, AU - Shaaker,Maghsod, AU - Ostadrahimi,Alireza, Y1 - 2016/03/24/ PY - 2016/3/25/pubmed PY - 2017/7/1/medline PY - 2016/3/25/entrez KW - DHA KW - EPA KW - fish oil supplementation KW - omega-3 KW - serum fatty acids SP - 137 EP - 153 JF - Women & health JO - Women Health VL - 57 IS - 2 N2 - Omega-3 fatty acids (FAs) are essential unsaturated long-chain FAs necessary for proper health and growth. The objective of the authors in this study was to evaluate the effect of fish oil supplementation in pregnancy on maternal serum FA profiles. Participants (n = 150 pregnant women aged 18-35 years in Tabriz, Iran) were randomly assigned to receive either 1,000 mg fish oil supplements daily containing 120 mg docosahexanoic acid (DHA) and 180 mg eicosapentaenoic acid (EPA), or placebo from week 21 of pregnancy to delivery. The primary outcome measures were mean serum DHA and EPA proportion of total FAs at weeks 35-37 of pregnancy. Analyses were based on intention-to-treat. No significant differences were observed between the groups in consumption of fish and serum FAs levels at baseline. Fish oil supplementation significantly increased the mean DHA proportion of total FAs in the intervention compared to the placebo group at weeks 35-37 [adjusted Mean Difference (aMD) = 0.15; 95% CI 0.08-0.23]. The mean EPA proportion of total FAs also increased in the intervention group, but the difference between the groups was not significant (aMD = 0.04; 95% CI -0.01 to 0.08). The dietary recommendation for consumption of 1,000 mg/day fish oil supplements during pregnancy seems beneficial for better serum FA composition. SN - 1541-0331 UR - https://www.unboundmedicine.com/medline/citation/27011294/The_effect_of_fish_oil_supplementation_on_serum_phospholipid_fatty_acids_profile_during_pregnancy:_A_double_blind_randomized_controlled_trial_ L2 - http://www.tandfonline.com/doi/full/10.1080/03630242.2016.1159269 DB - PRIME DP - Unbound Medicine ER -