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Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine.
Medicine (Baltimore). 2016 Mar; 95(12):e2886.M

Abstract

Pathological laughing and crying, or pseudobulbar affect (PBA), has been described in patients with neurological disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, and traumatic brain injury (TBI) since the 19th century (Schiffer 2005). The syndrome is characterized by inappropriate episodes of laughing or crying after minor stimuli. It was first coined a disinhibition of cortical control by Kinnier Wilson in 1924. It was observed in brain disease and seen with mild TBI. It can impair social and occupational function and is largely underrecognized in clinical settings. PBA is usually treated with antidepressants and dopaminergic agents. In this case we treated a military recruit with TBI with Nuedexta-a dextromethorphan/Quinidine derivative with a subsequent decrease in his episodes.

Authors+Show Affiliations

From the Regimental Aid Station, NHCL (DG-B); Department of Neurology, NHCL Intrepid Spine Concussion Recovery Center (TMJ, JW); and Speech-language Pathologist (JS, MG).No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27015166

Citation

Garcia-Baran, Dynela, et al. "Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine." Medicine, vol. 95, no. 12, 2016, pp. e2886.
Garcia-Baran D, Johnson TM, Wagner J, et al. Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine. Medicine (Baltimore). 2016;95(12):e2886.
Garcia-Baran, D., Johnson, T. M., Wagner, J., Shen, J., & Geers, M. (2016). Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine. Medicine, 95(12), e2886. https://doi.org/10.1097/MD.0000000000002886
Garcia-Baran D, et al. Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine. Medicine (Baltimore). 2016;95(12):e2886. PubMed PMID: 27015166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine. AU - Garcia-Baran,Dynela, AU - Johnson,Thomas M, AU - Wagner,Joyce, AU - Shen,Joann, AU - Geers,Michelle, PY - 2016/3/26/entrez PY - 2016/3/26/pubmed PY - 2016/8/3/medline SP - e2886 EP - e2886 JF - Medicine JO - Medicine (Baltimore) VL - 95 IS - 12 N2 - Pathological laughing and crying, or pseudobulbar affect (PBA), has been described in patients with neurological disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, and traumatic brain injury (TBI) since the 19th century (Schiffer 2005). The syndrome is characterized by inappropriate episodes of laughing or crying after minor stimuli. It was first coined a disinhibition of cortical control by Kinnier Wilson in 1924. It was observed in brain disease and seen with mild TBI. It can impair social and occupational function and is largely underrecognized in clinical settings. PBA is usually treated with antidepressants and dopaminergic agents. In this case we treated a military recruit with TBI with Nuedexta-a dextromethorphan/Quinidine derivative with a subsequent decrease in his episodes. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/27015166/Therapeutic_Approach_of_a_High_Functioning_Individual_With_Traumatic_Brain_Injury_and_Subsequent_Emotional_Volatility_With_Features_of_Pathological_Laughter_and_Crying_With_Dextromethorphan/Quinidine_ L2 - http://dx.doi.org/10.1097/MD.0000000000002886 DB - PRIME DP - Unbound Medicine ER -