Tags

Type your tag names separated by a space and hit enter

Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population.
Korean J Intern Med. 2016 Nov; 31(6):1120-1130.KJ

Abstract

BACKGROUND/AIMS

An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines.

METHODS

Cross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine.

RESULTS

Of the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively.

CONCLUSIONS

A large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage.

Authors+Show Affiliations

College of Pharmacy and Institute of Pharmaceutical Sciences, Gachon University, Incheon, Korea. Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea.Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27017386

Citation

Ji, Eunhee, and Yon Su Kim. "Prevalence of Chronic Kidney Disease Defined By Using CKD-EPI Equation and Albumin-to-creatinine Ratio in the Korean Adult Population." The Korean Journal of Internal Medicine, vol. 31, no. 6, 2016, pp. 1120-1130.
Ji E, Kim YS. Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. Korean J Intern Med. 2016;31(6):1120-1130.
Ji, E., & Kim, Y. S. (2016). Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. The Korean Journal of Internal Medicine, 31(6), 1120-1130.
Ji E, Kim YS. Prevalence of Chronic Kidney Disease Defined By Using CKD-EPI Equation and Albumin-to-creatinine Ratio in the Korean Adult Population. Korean J Intern Med. 2016;31(6):1120-1130. PubMed PMID: 27017386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. AU - Ji,Eunhee, AU - Kim,Yon Su, Y1 - 2016/03/25/ PY - 2015/06/29/received PY - 2015/07/31/revised PY - 2015/08/13/accepted PY - 2016/11/4/pubmed PY - 2017/8/16/medline PY - 2016/3/28/entrez KW - Albuminuria KW - Glomerular filtration rate KW - Kidney Disease Improving Global Outcomes KW - Korea KW - Renal insufficiency, chronic SP - 1120 EP - 1130 JF - The Korean journal of internal medicine JO - Korean J Intern Med VL - 31 IS - 6 N2 - BACKGROUND/AIMS: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines. METHODS: Cross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine. RESULTS: Of the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively. CONCLUSIONS: A large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/27017386/Prevalence_of_chronic_kidney_disease_defined_by_using_CKD_EPI_equation_and_albumin_to_creatinine_ratio_in_the_Korean_adult_population_ L2 - https://dx.doi.org/10.3904/kjim.2015.193 DB - PRIME DP - Unbound Medicine ER -