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Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population.

Abstract

BACKGROUND/AIMS

An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines.

METHODS

Cross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine.

RESULTS

Of the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively.

CONCLUSIONS

A large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage.

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  • Authors+Show Affiliations

    ,

    College of Pharmacy and Institute of Pharmaceutical Sciences, Gachon University, Incheon, Korea. Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea.

    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

    Source

    The Korean journal of internal medicine 31:6 2016 Nov pg 1120-1130

    MeSH

    Adult
    Age Distribution
    Aged
    Albuminuria
    Biomarkers
    Creatinine
    Cross-Sectional Studies
    Disease Progression
    Early Diagnosis
    Female
    Glomerular Filtration Rate
    Humans
    Kidney
    Male
    Middle Aged
    Models, Cardiovascular
    Nutrition Surveys
    Predictive Value of Tests
    Prevalence
    Renal Insufficiency, Chronic
    Republic of Korea
    Retrospective Studies
    Serum Albumin
    Serum Albumin, Human
    Sex Distribution
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27017386

    Citation

    Ji, Eunhee, and Yon Su Kim. "Prevalence of Chronic Kidney Disease Defined By Using CKD-EPI Equation and Albumin-to-creatinine Ratio in the Korean Adult Population." The Korean Journal of Internal Medicine, vol. 31, no. 6, 2016, pp. 1120-1130.
    Ji E, Kim YS. Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. Korean J Intern Med. 2016;31(6):1120-1130.
    Ji, E., & Kim, Y. S. (2016). Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. The Korean Journal of Internal Medicine, 31(6), pp. 1120-1130.
    Ji E, Kim YS. Prevalence of Chronic Kidney Disease Defined By Using CKD-EPI Equation and Albumin-to-creatinine Ratio in the Korean Adult Population. Korean J Intern Med. 2016;31(6):1120-1130. PubMed PMID: 27017386.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence of chronic kidney disease defined by using CKD-EPI equation and albumin-to-creatinine ratio in the Korean adult population. AU - Ji,Eunhee, AU - Kim,Yon Su, Y1 - 2016/03/25/ PY - 2015/06/29/received PY - 2015/07/31/revised PY - 2015/08/13/accepted PY - 2016/11/4/pubmed PY - 2017/8/16/medline PY - 2016/3/28/entrez KW - Albuminuria KW - Glomerular filtration rate KW - Kidney Disease Improving Global Outcomes KW - Korea KW - Renal insufficiency, chronic SP - 1120 EP - 1130 JF - The Korean journal of internal medicine JO - Korean J. Intern. Med. VL - 31 IS - 6 N2 - BACKGROUND/AIMS: An updated chronic kidney disease (CKD) definition and classification were proposed by Kidney Disease: Improving Global Outcomes (KDIGO), with adoption of a new equation to estimate glomerular filtration rate (GFR) and albuminuria to evaluate kidney structural damage. This study was performed to estimate the prevalence of CKD in the Korean adult population as defined and classified by the KDIGO guidelines. METHODS: Cross-sectional samples of the fifth Korean National Health and Nutrition Examination Survey for 2011 to 2012 were examined for adults aged ≥ 19 years. CKD prevalence was determined based on decreased GFR and albuminuria. The GFR was estimated using the CKD Epidemiology Collaboration creatinine equation, and albuminuria was evaluated using the albumin-to-creatinine ratio (ACR) in spot urine. RESULTS: Of the 16,576 subjects participating in the survey, 10,636 (4,758 men, 5,878 women) were included in the present study. The prevalence of CKD was estimated as 7.9% (7.8% in 2011 and 8.0% in 2012, p = 0.770). The prevalence of low, moderately increased, high, and very high CKD risk prognosis was 92.0%, 6.3%, 1.1%, and 0.6%, respectively. The prevalence of albuminuria (ACR ≥ 30 mg/g) in individuals with GFR ≥ 60 mL/min/1.73 m2 has reached 5.7%. The odds ratios of hypertension and diabetes to CKD were 3.4 and 3.1 in men, and 2.9 and 2.0 in women (all p < 0.001), respectively. CONCLUSIONS: A large percentage of CKD patients had albuminuria prior to a decrease in GFR. Regular laboratory tests for albuminuria for the high-risk group, and especially for hypertensive or diabetic patients, might improve detection of CKD at an early stage. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/27017386/Prevalence_of_chronic_kidney_disease_defined_by_using_CKD_EPI_equation_and_albumin_to_creatinine_ratio_in_the_Korean_adult_population_ L2 - https://dx.doi.org/10.3904/kjim.2015.193 DB - PRIME DP - Unbound Medicine ER -