Tags

Type your tag names separated by a space and hit enter

Sural and Radial Sensory Responses in Patients with Sensory Polyneuropathy.
Clin Med Rev Case Rep. 2015; 2(3)CM

Abstract

INTRODUCTION

The sural/radial nerve amplitude ratio (SRAR) is the quotient of the sensory nerve action potential (SNAP) amplitudes (Amp) of the sural and the superficial radial nerve. It has been hypothesized that this ratio can be used for the detection of early axonal loss, because the sural SNAP amplitude will decrease first, thereby also decreasing the SRAR value.

OBJECTIVES

To determine the sensitivity and specificity of SRAR, age-adjusted sural and radial SNAP Amp in the diagnosis of axonal sensory polyneuropathy in cancer patients.

DESIGN

Retrospective review.

SETTING

Comprehensive cancer center.

PATIENTS

One hundred and ninety one EMG reports from January 2001 to December 2005.

METHODS

The independent variable is the diagnosis of axonal sensory polyneuropathy in the EMG reports that is based on multiple tests.

MAIN OUTCOME MEASUREMENTS

We assessed the agreement between classifications of axonal sensory polyneuropathy made using the current 'gold standard' and the proposed method that is based on patients' age-adjusted radial and sural SNAP amplitude; an SRAR being above or below the normal value (0.21).

RESULTS

We found that the sensitivities for age-adjusted radial SNAP Amp, age-adjusted sural SNAP Amp, and SRAR were 33%, 64%, 56% respectively; the specificities were 85%, 70%, 77% respectively.

CONCLUSIONS

SRAR is neither the most sensitive, nor the most specific in the diagnosis of axonal sensory polyneuropathy.

Authors+Show Affiliations

Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center.Department of Biostatistics, University of Texas MD Anderson Cancer Center.Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center.Department of Palliative Care & Rehabilitation Medicine, University of Texas MD Anderson Cancer Center.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27019870

Citation

Guo, Ying, et al. "Sural and Radial Sensory Responses in Patients With Sensory Polyneuropathy." Clinical Medical Reviews and Case Reports, vol. 2, no. 3, 2015.
Guo Y, Palmer JL, Brown XS, et al. Sural and Radial Sensory Responses in Patients with Sensory Polyneuropathy. Clin Med Rev Case Rep. 2015;2(3).
Guo, Y., Palmer, J. L., Brown, X. S., & Fu, J. B. (2015). Sural and Radial Sensory Responses in Patients with Sensory Polyneuropathy. Clinical Medical Reviews and Case Reports, 2(3).
Guo Y, et al. Sural and Radial Sensory Responses in Patients With Sensory Polyneuropathy. Clin Med Rev Case Rep. 2015;2(3) PubMed PMID: 27019870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sural and Radial Sensory Responses in Patients with Sensory Polyneuropathy. AU - Guo,Ying, AU - Palmer,J Lynn, AU - Brown,Xun S, AU - Fu,Jack B, Y1 - 2015/08/21/ PY - 2016/3/29/entrez PY - 2015/1/1/pubmed PY - 2015/1/1/medline KW - polyneuropathy KW - radial nerve KW - sural nerve KW - sural/radial amplitude ratio (SRAR) JF - Clinical medical reviews and case reports JO - Clin Med Rev Case Rep VL - 2 IS - 3 N2 - INTRODUCTION: The sural/radial nerve amplitude ratio (SRAR) is the quotient of the sensory nerve action potential (SNAP) amplitudes (Amp) of the sural and the superficial radial nerve. It has been hypothesized that this ratio can be used for the detection of early axonal loss, because the sural SNAP amplitude will decrease first, thereby also decreasing the SRAR value. OBJECTIVES: To determine the sensitivity and specificity of SRAR, age-adjusted sural and radial SNAP Amp in the diagnosis of axonal sensory polyneuropathy in cancer patients. DESIGN: Retrospective review. SETTING: Comprehensive cancer center. PATIENTS: One hundred and ninety one EMG reports from January 2001 to December 2005. METHODS: The independent variable is the diagnosis of axonal sensory polyneuropathy in the EMG reports that is based on multiple tests. MAIN OUTCOME MEASUREMENTS: We assessed the agreement between classifications of axonal sensory polyneuropathy made using the current 'gold standard' and the proposed method that is based on patients' age-adjusted radial and sural SNAP amplitude; an SRAR being above or below the normal value (0.21). RESULTS: We found that the sensitivities for age-adjusted radial SNAP Amp, age-adjusted sural SNAP Amp, and SRAR were 33%, 64%, 56% respectively; the specificities were 85%, 70%, 77% respectively. CONCLUSIONS: SRAR is neither the most sensitive, nor the most specific in the diagnosis of axonal sensory polyneuropathy. SN - 2378-3656 UR - https://www.unboundmedicine.com/medline/citation/27019870/Sural_and_Radial_Sensory_Responses_in_Patients_with_Sensory_Polyneuropathy_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27019870/ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.