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25-Hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study.
Public Health Nutr. 2017 Jul; 20(10):1775-1784.PH

Abstract

OBJECTIVE

To investigate relationships between mortality and circulating 25-hydroxyvitamin D (25(OH)D), 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2).

DESIGN

Case-cohort study within the Melbourne Collaborative Cohort Study (MCCS). We measured 25(OH)D2 and 25(OH)D3 in archived dried blood spots by LC-MS/MS. Cox regression was used to estimate mortality hazard ratios (HR), with adjustment for confounders.

SETTING

General community.

SUBJECTS

The MCCS included 29 206 participants, who at recruitment in 1990-1994 were aged 40-69 years, had dried blood spots collected and no history of cancer. For the present study we selected participants who died by 31 December 2007 (n 2410) and a random sample (sub-cohort, n 2996).

RESULTS

The HR per 25 nmol/l increment in concentration of 25(OH)D and 25(OH)D3 were 0·86 (95 % CI 0·78, 0·96; P=0·007) and 0·85 (95 % CI 0·77, 0·95; P=0·003), respectively. Of 5108 participants, sixty-three (1·2 %) had detectable 25(OH)D2; their mean 25(OH)D concentration was 11·9 (95 % CI 7·3, 16·6) nmol/l higher (P<0·001). The HR for detectable 25(OH)D2 was 1·80 (95 % CI 1·09, 2·97; P=0·023); for those with detectable 25(OH)D2, the HR per 25 nmol/l increment in 25(OH)D was 1·06 (95 % CI 0·87, 1·29; P interaction=0·02). HR were similar for participants who reported being in good, very good or excellent health four years after recruitment.

CONCLUSIONS

Total 25(OH)D and 25(OH)D3 concentrations were inversely associated with mortality. The finding that the inverse association for 25(OH)D was restricted to those with no detectable 25(OH)D2 requires confirmation in populations with higher exposure to ergocalciferol.

Links

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Authors+Show Affiliations

Heath AK
1Centre for Epidemiology and Biostatistics,Melbourne School of Population and Global Health,The University of Melbourne,Level 3,207 Bouverie Street,Melbourne,Victoria 3010,Australia.
Williamson EJ
3Farr Institute of Health Informatics Research,London,UK.
Kvaskoff D
5Queensland Brain Institute,The University of Queensland,St Lucia,Queensland,Australia.
Hodge AM
2Cancer Epidemiology Centre,Cancer Council Victoria,Melbourne,Victoria,Australia.
Ebeling PR
6Department of Medicine,School of Clinical Sciences,Monash University,Clayton,Victoria,Australia.
Baglietto L
1Centre for Epidemiology and Biostatistics,Melbourne School of Population and Global Health,The University of Melbourne,Level 3,207 Bouverie Street,Melbourne,Victoria 3010,Australia.
Neale RE
9Population Health Division,QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Giles GG
1Centre for Epidemiology and Biostatistics,Melbourne School of Population and Global Health,The University of Melbourne,Level 3,207 Bouverie Street,Melbourne,Victoria 3010,Australia.
Eyles DW
5Queensland Brain Institute,The University of Queensland,St Lucia,Queensland,Australia.
English DR
1Centre for Epidemiology and Biostatistics,Melbourne School of Population and Global Health,The University of Melbourne,Level 3,207 Bouverie Street,Melbourne,Victoria 3010,Australia.

MeSH

AdultAgedAustraliaChromatography, LiquidCohort StudiesCooperative BehaviorFemaleHumansMaleMiddle AgedMortalityProportional Hazards ModelsTandem Mass SpectrometryVitamin D

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27021065

Citation

Heath, Alicia K., et al. "25-Hydroxyvitamin D Concentration and All-cause Mortality: the Melbourne Collaborative Cohort Study." Public Health Nutrition, vol. 20, no. 10, 2017, pp. 1775-1784.
Heath AK, Williamson EJ, Kvaskoff D, et al. 25-Hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutr. 2017;20(10):1775-1784.
Heath, A. K., Williamson, E. J., Kvaskoff, D., Hodge, A. M., Ebeling, P. R., Baglietto, L., Neale, R. E., Giles, G. G., Eyles, D. W., & English, D. R. (2017). 25-Hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. Public Health Nutrition, 20(10), 1775-1784. https://doi.org/10.1017/S1368980016000501
Heath AK, et al. 25-Hydroxyvitamin D Concentration and All-cause Mortality: the Melbourne Collaborative Cohort Study. Public Health Nutr. 2017;20(10):1775-1784. PubMed PMID: 27021065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 25-Hydroxyvitamin D concentration and all-cause mortality: the Melbourne Collaborative Cohort Study. AU - Heath,Alicia K, AU - Williamson,Elizabeth J, AU - Kvaskoff,David, AU - Hodge,Allison M, AU - Ebeling,Peter R, AU - Baglietto,Laura, AU - Neale,Rachel E, AU - Giles,Graham G, AU - Eyles,Darryl W, AU - English,Dallas R, Y1 - 2016/03/29/ PY - 2016/3/30/pubmed PY - 2018/7/17/medline PY - 2016/3/30/entrez KW - 25-Hydroxyvitamin D KW - All-cause mortality KW - Cholecalciferol KW - Ergocalciferol SP - 1775 EP - 1784 JF - Public health nutrition JO - Public Health Nutr VL - 20 IS - 10 N2 - OBJECTIVE: To investigate relationships between mortality and circulating 25-hydroxyvitamin D (25(OH)D), 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2). DESIGN: Case-cohort study within the Melbourne Collaborative Cohort Study (MCCS). We measured 25(OH)D2 and 25(OH)D3 in archived dried blood spots by LC-MS/MS. Cox regression was used to estimate mortality hazard ratios (HR), with adjustment for confounders. SETTING: General community. SUBJECTS: The MCCS included 29 206 participants, who at recruitment in 1990-1994 were aged 40-69 years, had dried blood spots collected and no history of cancer. For the present study we selected participants who died by 31 December 2007 (n 2410) and a random sample (sub-cohort, n 2996). RESULTS: The HR per 25 nmol/l increment in concentration of 25(OH)D and 25(OH)D3 were 0·86 (95 % CI 0·78, 0·96; P=0·007) and 0·85 (95 % CI 0·77, 0·95; P=0·003), respectively. Of 5108 participants, sixty-three (1·2 %) had detectable 25(OH)D2; their mean 25(OH)D concentration was 11·9 (95 % CI 7·3, 16·6) nmol/l higher (P<0·001). The HR for detectable 25(OH)D2 was 1·80 (95 % CI 1·09, 2·97; P=0·023); for those with detectable 25(OH)D2, the HR per 25 nmol/l increment in 25(OH)D was 1·06 (95 % CI 0·87, 1·29; P interaction=0·02). HR were similar for participants who reported being in good, very good or excellent health four years after recruitment. CONCLUSIONS: Total 25(OH)D and 25(OH)D3 concentrations were inversely associated with mortality. The finding that the inverse association for 25(OH)D was restricted to those with no detectable 25(OH)D2 requires confirmation in populations with higher exposure to ergocalciferol. SN - 1475-2727 UR - https://www.unboundmedicine.com/medline/citation/27021065/25_Hydroxyvitamin_D_concentration_and_all_cause_mortality:_the_Melbourne_Collaborative_Cohort_Study_ DB - PRIME DP - Unbound Medicine ER -
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