Tags

Type your tag names separated by a space and hit enter

Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects.
J Matern Fetal Neonatal Med 2016; 29(23):3894-901JM

Abstract

OBJECTIVE

To find out the prevention effects of folic acid supplements during different pregnancy periods on neural tube defects (NTDs) and the relationship of folic acid supplements with the other NTDs' primary preventive measures.

METHODS

A 1:1 case-control study was conducted. Four hundred and fifty-nine women who delivered or gestate infants/fetuses with NTDs in the last two years were randomly selected as cases and were matched with women who delivered babies without obvious birth defects as controls.

RESULTS

For anencephaly, folic acid supplementation during the periconceptional period and preconceptional period has a 57-83% reduction in risk of NTDs(ORs ranged from 0.17 to 0.43). For spina bifida, folic acid supplementation during the periconceptional period has a 79% reduction in risk of NTDs (OR = 0.21). For encephalocele, folic acid supplementation during the periconceptional period has a 67% reduction in risk of NTDs (OR = 0.33). The prevention effects on NTDs were significant when these preventive measures combined with folic acid supplements during the periconceptional period, with OR 0.04, 0.07, 0.10 and 0.11.

CONCLUSION

The specific effects of folic acid supplementation during different periods show the reduction in the risk of NTDs, anencephaly, spina bifida, encephalocele. During periconceptional period, folic acid supplements have preventive effects on all NTDs' subtypes.

Authors+Show Affiliations

a Institute of Population Research, Peking University , Beijing , China . b Department of Epidemiology and Health Statistics , School of Public Health, Shandong University , Jinan , China . c China Rehabilitation Research Centre for Deaf Children , Beijing , China .b Department of Epidemiology and Health Statistics , School of Public Health, Shandong University , Jinan , China .d Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou City , China.b Department of Epidemiology and Health Statistics , School of Public Health, Shandong University , Jinan , China .b Department of Epidemiology and Health Statistics , School of Public Health, Shandong University , Jinan , China .

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27023398

Citation

Gong, Rui, et al. "Effects of Folic Acid Supplementation During Different Pregnancy Periods and Relationship With the Other Primary Prevention Measures to Neural Tube Defects." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 29, no. 23, 2016, pp. 3894-901.
Gong R, Wang ZP, Wang M, et al. Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects. J Matern Fetal Neonatal Med. 2016;29(23):3894-901.
Gong, R., Wang, Z. P., Wang, M., Gao, L. J., & Zhao, Z. T. (2016). Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(23), pp. 3894-901. doi:10.3109/14767058.2016.1152241.
Gong R, et al. Effects of Folic Acid Supplementation During Different Pregnancy Periods and Relationship With the Other Primary Prevention Measures to Neural Tube Defects. J Matern Fetal Neonatal Med. 2016;29(23):3894-901. PubMed PMID: 27023398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects. AU - Gong,Rui, AU - Wang,Zhi-Ping, AU - Wang,Meng, AU - Gao,Li-Jie, AU - Zhao,Zhong-Tang, Y1 - 2016/03/29/ PY - 2016/3/30/entrez PY - 2016/3/30/pubmed PY - 2017/6/15/medline KW - Anencephaly KW - folic acid KW - neural tube defects KW - periconceptional period KW - preventive measures KW - spina bifida SP - 3894 EP - 901 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 29 IS - 23 N2 - OBJECTIVE: To find out the prevention effects of folic acid supplements during different pregnancy periods on neural tube defects (NTDs) and the relationship of folic acid supplements with the other NTDs' primary preventive measures. METHODS: A 1:1 case-control study was conducted. Four hundred and fifty-nine women who delivered or gestate infants/fetuses with NTDs in the last two years were randomly selected as cases and were matched with women who delivered babies without obvious birth defects as controls. RESULTS: For anencephaly, folic acid supplementation during the periconceptional period and preconceptional period has a 57-83% reduction in risk of NTDs(ORs ranged from 0.17 to 0.43). For spina bifida, folic acid supplementation during the periconceptional period has a 79% reduction in risk of NTDs (OR = 0.21). For encephalocele, folic acid supplementation during the periconceptional period has a 67% reduction in risk of NTDs (OR = 0.33). The prevention effects on NTDs were significant when these preventive measures combined with folic acid supplements during the periconceptional period, with OR 0.04, 0.07, 0.10 and 0.11. CONCLUSION: The specific effects of folic acid supplementation during different periods show the reduction in the risk of NTDs, anencephaly, spina bifida, encephalocele. During periconceptional period, folic acid supplements have preventive effects on all NTDs' subtypes. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/27023398/Effects_of_folic_acid_supplementation_during_different_pregnancy_periods_and_relationship_with_the_other_primary_prevention_measures_to_neural_tube_defects_ L2 - http://www.tandfonline.com/doi/full/10.3109/14767058.2016.1152241 DB - PRIME DP - Unbound Medicine ER -