Citation
Magierowska, Katarzyna, et al. "The Protective Role of Carbon Monoxide (CO) Produced By Heme Oxygenases and Derived From the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)." International Journal of Molecular Sciences, vol. 17, no. 4, 2016, p. 442.
Magierowska K, Magierowski M, Surmiak M, et al. The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO). Int J Mol Sci. 2016;17(4):442.
Magierowska, K., Magierowski, M., Surmiak, M., Adamski, J., Mazur-Bialy, A. I., Pajdo, R., Sliwowski, Z., Kwiecien, S., & Brzozowski, T. (2016). The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO). International Journal of Molecular Sciences, 17(4), 442. https://doi.org/10.3390/ijms17040442
Magierowska K, et al. The Protective Role of Carbon Monoxide (CO) Produced By Heme Oxygenases and Derived From the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO). Int J Mol Sci. 2016 Mar 24;17(4):442. PubMed PMID: 27023525.
TY - JOUR
T1 - The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO).
AU - Magierowska,Katarzyna,
AU - Magierowski,Marcin,
AU - Surmiak,Marcin,
AU - Adamski,Juliusz,
AU - Mazur-Bialy,Agnieszka Irena,
AU - Pajdo,Robert,
AU - Sliwowski,Zbigniew,
AU - Kwiecien,Slawomir,
AU - Brzozowski,Tomasz,
Y1 - 2016/03/24/
PY - 2016/01/24/received
PY - 2016/03/18/revised
PY - 2016/03/18/accepted
PY - 2016/3/30/entrez
PY - 2016/3/31/pubmed
PY - 2016/12/15/medline
KW - carbon monoxide
KW - cyclooxygenases
KW - gastric blood flow
KW - gastroprotection
KW - heme oxygenase-1
KW - hypoxia inducible factor 1α
KW - nitric oxide
KW - soluble guanylyl cyclase
KW - stress
SP - 442
EP - 442
JF - International journal of molecular sciences
JO - Int J Mol Sci
VL - 17
IS - 4
N2 - Carbon monoxide (CO) produced by heme oxygenase (HO)-1 and HO-2 or released from the CO-donor, tricarbonyldichlororuthenium (II) dimer (CORM-2) causes vasodilation, with unknown efficacy against stress-induced gastric lesions. We studied whether pretreatment with CORM-2 (0.1-10 mg/kg oral gavage (i.g.)), RuCl₃ (1 mg/kg i.g.), zinc protoporphyrin IX (ZnPP) (10 mg/kg intraperitoneally (i.p.)), hemin (1-10 mg/kg i.g.) and CORM-2 (1 mg/kg i.g.) combined with N(G)-nitro-l-arginine (l-NNA, 20 mg/kg i.p.), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10 mg/kg i.p.), indomethacin (5 mg/kg i.p.), SC-560 (5 mg/kg i.g.), and celecoxib (10 mg/kg i.g.) affects gastric lesions following 3.5 h of water immersion and restraint stress (WRS). Gastric blood flow (GBF), the number of gastric lesions and gastric CO and nitric oxide (NO) contents, blood carboxyhemoglobin (COHb) level and the gastric expression of HO-1, HO-2, hypoxia inducible factor 1α (HIF-1α), tumor necrosis factor α (TNF-α), cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) were determined. CORM-2 (1 mg/kg i.g.) and hemin (10 mg/kg i.g.) significantly decreased WRS lesions while increasing GBF, however, RuCl₃ was ineffective. The impact of CORM-2 was reversed by ZnPP, ODQ, indomethacin, SC-560 and celecoxib, but not by l-NNA. CORM-2 decreased NO and increased HO-1 expression and CO and COHb content, downregulated HIF-1α, as well as WRS-elevated COX-2 and iNOS mRNAs. Gastroprotection by CORM-2 and HO depends upon CO's hyperemic and anti-inflammatory properties, but is independent of NO.
SN - 1422-0067
UR - https://www.unboundmedicine.com/medline/citation/27023525/The_Protective_Role_of_Carbon_Monoxide__CO__Produced_by_Heme_Oxygenases_and_Derived_from_the_CO_Releasing_Molecule_CORM_2_in_the_Pathogenesis_of_Stress_Induced_Gastric_Lesions:_Evidence_for_Non_Involvement_of_Nitric_Oxide__NO__
L2 - https://www.mdpi.com/resolver?pii=ijms17040442
DB - PRIME
DP - Unbound Medicine
ER -