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Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort.
Eur J Clin Nutr 2016; 70(9):1022-7EJ

Abstract

BACKGROUND/OBJECTIVES

Obesity and diabetes rates are high in Native Hawaiians (NHs) who commonly have mixed ancestries. People of Asian ancestry experience a high risk of type 2 diabetes despite the relatively low body weight. We evaluated the impact of ethnic admixture on diabetes risk among NHs in the Multiethnic Cohort (MEC).

SUBJECTS/METHODS

On the basis of self-reports, 11 521 eligible men and women were categorized into NH/white, NH/other, NH alone, NH/Asian and the most common three ancestry admixture, NH/Chinese/white. Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with the NH/white category as the reference group; covariates included known confounders-that is, body mass index (BMI), dietary and other lifestyle factors.

RESULTS

The NH alone category had the highest proportion of overweight and obese individuals and the NH/Asian category the lowest proportion. During 12 years of follow-up after cohort entry at 56 years, 2072 incident cases were ascertained through questionnaires and health plan linkages. All NH categories had higher HRs than the NH/white category before and after adjustment for BMI. In the fully adjusted models, the NH/Asian category showed the highest risk (HR=1.45; 95% CI: 1.27-1.65), followed by NH/other (HR=1.20; 95% CI: 1.03-1.39), NH/Chinese/white (HR=1.19; 95% CI: 1.04-1.37) and NH alone (HR=1.19; 95% CI: 1.03-1.37). The elevated risk by Asian admixture was more pronounced in normal weight than overweight/obese individuals.

CONCLUSIONS

These findings indicate that Asian admixture in NHs is associated with a higher risk for type 2 diabetes independent of known risk factors and suggest a role for ethnicity-related genetic factors in the development of this disease.

Authors+Show Affiliations

University of Hawaii Cancer Center, Honolulu, HI, USA.University of Hawaii Cancer Center, Honolulu, HI, USA.German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany.Office of Public Health Studies, University of Hawaii, Honolulu, HI, USA.Department of Native Hawaiian Health, JABSOM, University of Hawaii, Honolulu, HI, USA.University of Hawaii Cancer Center, Honolulu, HI, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

27026423

Citation

Maskarinec, G, et al. "Ethnic Admixture Affects Diabetes Risk in Native Hawaiians: the Multiethnic Cohort." European Journal of Clinical Nutrition, vol. 70, no. 9, 2016, pp. 1022-7.
Maskarinec G, Morimoto Y, Jacobs S, et al. Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. Eur J Clin Nutr. 2016;70(9):1022-7.
Maskarinec, G., Morimoto, Y., Jacobs, S., Grandinetti, A., Mau, M. K., & Kolonel, L. N. (2016). Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. European Journal of Clinical Nutrition, 70(9), pp. 1022-7. doi:10.1038/ejcn.2016.32.
Maskarinec G, et al. Ethnic Admixture Affects Diabetes Risk in Native Hawaiians: the Multiethnic Cohort. Eur J Clin Nutr. 2016;70(9):1022-7. PubMed PMID: 27026423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. AU - Maskarinec,G, AU - Morimoto,Y, AU - Jacobs,S, AU - Grandinetti,A, AU - Mau,M K, AU - Kolonel,L N, Y1 - 2016/03/30/ PY - 2015/04/15/received PY - 2015/12/11/revised PY - 2016/01/17/accepted PY - 2016/3/31/entrez PY - 2016/3/31/pubmed PY - 2018/1/27/medline SP - 1022 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 70 IS - 9 N2 - BACKGROUND/OBJECTIVES: Obesity and diabetes rates are high in Native Hawaiians (NHs) who commonly have mixed ancestries. People of Asian ancestry experience a high risk of type 2 diabetes despite the relatively low body weight. We evaluated the impact of ethnic admixture on diabetes risk among NHs in the Multiethnic Cohort (MEC). SUBJECTS/METHODS: On the basis of self-reports, 11 521 eligible men and women were categorized into NH/white, NH/other, NH alone, NH/Asian and the most common three ancestry admixture, NH/Chinese/white. Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with the NH/white category as the reference group; covariates included known confounders-that is, body mass index (BMI), dietary and other lifestyle factors. RESULTS: The NH alone category had the highest proportion of overweight and obese individuals and the NH/Asian category the lowest proportion. During 12 years of follow-up after cohort entry at 56 years, 2072 incident cases were ascertained through questionnaires and health plan linkages. All NH categories had higher HRs than the NH/white category before and after adjustment for BMI. In the fully adjusted models, the NH/Asian category showed the highest risk (HR=1.45; 95% CI: 1.27-1.65), followed by NH/other (HR=1.20; 95% CI: 1.03-1.39), NH/Chinese/white (HR=1.19; 95% CI: 1.04-1.37) and NH alone (HR=1.19; 95% CI: 1.03-1.37). The elevated risk by Asian admixture was more pronounced in normal weight than overweight/obese individuals. CONCLUSIONS: These findings indicate that Asian admixture in NHs is associated with a higher risk for type 2 diabetes independent of known risk factors and suggest a role for ethnicity-related genetic factors in the development of this disease. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/27026423/Ethnic_admixture_affects_diabetes_risk_in_native_Hawaiians:_the_Multiethnic_Cohort_ L2 - http://dx.doi.org/10.1038/ejcn.2016.32 DB - PRIME DP - Unbound Medicine ER -