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Vitamin D for the treatment of painful diabetic neuropathy.

Abstract

OBJECTIVE

To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.

METHODS

A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.

RESULTS

143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).

CONCLUSIONS

Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.

TRIAL REGISTRATION NUMBER

BIDE-12/2014.

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  • Authors+Show Affiliations

    ,

    Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan; Baqai Medical University, Karachi, Pakistan.

    ,

    Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.

    ,

    Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan; Baqai Medical University, Karachi, Pakistan.

    ,

    Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.

    ,

    Baqai Institute of Diabetology and Endocrinology , Karachi , Pakistan.

    ,

    Weill Cornell Medicine-Qatar, Qatar Foundation , Doha , Qatar.

    ,

    Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust , Manchester , UK.

    Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar; Centre for Endocrinology and Diabetes, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK.

    Source

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27026808

    Citation

    Basit, Abdul, et al. "Vitamin D for the Treatment of Painful Diabetic Neuropathy." BMJ Open Diabetes Research & Care, vol. 4, no. 1, 2016, pp. e000148.
    Basit A, Basit KA, Fawwad A, et al. Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care. 2016;4(1):e000148.
    Basit, A., Basit, K. A., Fawwad, A., Shaheen, F., Fatima, N., Petropoulos, I. N., ... Malik, R. A. (2016). Vitamin D for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Research & Care, 4(1), pp. e000148. doi:10.1136/bmjdrc-2015-000148.
    Basit A, et al. Vitamin D for the Treatment of Painful Diabetic Neuropathy. BMJ Open Diabetes Res Care. 2016;4(1):e000148. PubMed PMID: 27026808.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D for the treatment of painful diabetic neuropathy. AU - Basit,Abdul, AU - Basit,Khalid Abdul, AU - Fawwad,Asher, AU - Shaheen,Fariha, AU - Fatima,Nimra, AU - Petropoulos,Ioannis N, AU - Alam,Uazman, AU - Malik,Rayaz A, Y1 - 2016/02/10/ PY - 2015/08/08/received PY - 2015/10/12/revised PY - 2015/11/13/accepted PY - 2016/3/31/entrez PY - 2016/3/31/pubmed PY - 2016/3/31/medline KW - Neuropathy Complications KW - Neuropathy and Clinical Diabetes KW - Pain KW - Vitamin D SP - e000148 EP - e000148 JF - BMJ open diabetes research & care JO - BMJ Open Diabetes Res Care VL - 4 IS - 1 N2 - OBJECTIVE: To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy. METHODS: A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks. RESULTS: 143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001). CONCLUSIONS: Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy. TRIAL REGISTRATION NUMBER: BIDE-12/2014. SN - 2052-4897 UR - https://www.unboundmedicine.com/medline/citation/27026808/Vitamin_D_for_the_treatment_of_painful_diabetic_neuropathy_ L2 - http://dx.doi.org/10.1136/bmjdrc-2015-000148 DB - PRIME DP - Unbound Medicine ER -