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Locomotor, discriminative stimulus, and place conditioning effects of MDAI in rodents.
Behav Pharmacol. 2016 09; 27(6):497-505.BP

Abstract

5,6-Methylenedioxy-2-aminoindane (MDAI) has become a common substitute for (±)-3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy. MDAI is known to produce MDMA-like discriminative stimulus effects, but it is not known whether MDAI has psychostimulant or hallucinogen-like effects. MDAI was tested for locomotor stimulant effects in mice and subsequently for discriminative stimulus effects in rats trained to discriminate cocaine (10 mg/kg, intraperitoneally), methamphetamine (1 mg/kg, intraperitoneally), ±MDMA (1.5 mg/kg, intraperitoneally), or (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride (0.5 mg/kg, intraperitoneally) from saline. The ability of MDAI to produce conditioned place preference was also tested in mice. MDAI (3 to 30 mg/kg) depressed locomotor activity from 10 to 60 min. A rebound stimulant effect was observed at 1 to 3.5 h following 30 mg/kg. Lethality occurred in 8/8 mice following 100 mg/kg MDAI. Similarly, MDMA depressed locomotor activity immediately following the administration of 0.25 mg/kg and stimulant effects were observed 50-70 min following the administration of 0.5 and 1 mg/kg. MDAI fully substituted for the discriminative stimulus effects of MDMA (2.5 mg/kg), (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride (5 mg/kg), and cocaine (7.5 mg/kg), but produced only 73% methamphetamine-appropriate responding at a dose that suppressed responding (7.5 mg/kg). MDAI produced tremors at 10 mg/kg in one methamphetamine-trained rat. MDAI produced conditioned place preference from 0.3 to 10 mg/kg. The effects of MDAI on locomotor activity and drug discrimination were similar to those produced by MDMA, having both psychostimulant-like and hallucinogen-like effects; thus, MDAI may have similar abuse potential as MDMA.

Authors+Show Affiliations

Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

27028902

Citation

Gatch, Michael B., et al. "Locomotor, Discriminative Stimulus, and Place Conditioning Effects of MDAI in Rodents." Behavioural Pharmacology, vol. 27, no. 6, 2016, pp. 497-505.
Gatch MB, Dolan SB, Forster MJ. Locomotor, discriminative stimulus, and place conditioning effects of MDAI in rodents. Behav Pharmacol. 2016;27(6):497-505.
Gatch, M. B., Dolan, S. B., & Forster, M. J. (2016). Locomotor, discriminative stimulus, and place conditioning effects of MDAI in rodents. Behavioural Pharmacology, 27(6), 497-505. https://doi.org/10.1097/FBP.0000000000000237
Gatch MB, Dolan SB, Forster MJ. Locomotor, Discriminative Stimulus, and Place Conditioning Effects of MDAI in Rodents. Behav Pharmacol. 2016;27(6):497-505. PubMed PMID: 27028902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locomotor, discriminative stimulus, and place conditioning effects of MDAI in rodents. AU - Gatch,Michael B, AU - Dolan,Sean B, AU - Forster,Michael J, PY - 2016/3/31/entrez PY - 2016/3/31/pubmed PY - 2017/11/29/medline SP - 497 EP - 505 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 27 IS - 6 N2 - 5,6-Methylenedioxy-2-aminoindane (MDAI) has become a common substitute for (±)-3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy. MDAI is known to produce MDMA-like discriminative stimulus effects, but it is not known whether MDAI has psychostimulant or hallucinogen-like effects. MDAI was tested for locomotor stimulant effects in mice and subsequently for discriminative stimulus effects in rats trained to discriminate cocaine (10 mg/kg, intraperitoneally), methamphetamine (1 mg/kg, intraperitoneally), ±MDMA (1.5 mg/kg, intraperitoneally), or (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride (0.5 mg/kg, intraperitoneally) from saline. The ability of MDAI to produce conditioned place preference was also tested in mice. MDAI (3 to 30 mg/kg) depressed locomotor activity from 10 to 60 min. A rebound stimulant effect was observed at 1 to 3.5 h following 30 mg/kg. Lethality occurred in 8/8 mice following 100 mg/kg MDAI. Similarly, MDMA depressed locomotor activity immediately following the administration of 0.25 mg/kg and stimulant effects were observed 50-70 min following the administration of 0.5 and 1 mg/kg. MDAI fully substituted for the discriminative stimulus effects of MDMA (2.5 mg/kg), (-)-2,5-dimethoxy-4-methylamphetamine hydrochloride (5 mg/kg), and cocaine (7.5 mg/kg), but produced only 73% methamphetamine-appropriate responding at a dose that suppressed responding (7.5 mg/kg). MDAI produced tremors at 10 mg/kg in one methamphetamine-trained rat. MDAI produced conditioned place preference from 0.3 to 10 mg/kg. The effects of MDAI on locomotor activity and drug discrimination were similar to those produced by MDMA, having both psychostimulant-like and hallucinogen-like effects; thus, MDAI may have similar abuse potential as MDMA. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/27028902/Locomotor_discriminative_stimulus_and_place_conditioning_effects_of_MDAI_in_rodents_ L2 - http://dx.doi.org/10.1097/FBP.0000000000000237 DB - PRIME DP - Unbound Medicine ER -