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Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness.
J Investig Med 2016; 64(5):1035-41JI

Abstract

Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.

Authors+Show Affiliations

Department of Pulmonology, Ataturk Chest and Chest Surgery Education and Research Hospital, Ankara, Turkey.Department of Biochemistry, Faculty of Medicine, Mevlana University, Konya, Turkey.Department of Radiology, Faculty of Medicine, Mevlana University, Konya, Turkey.Department of Radiology, Faculty of Medicine, Mevlana University, Konya, Turkey.Department of Pulmonology, Faculty of Medicine, Ordu University, Ordu, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27029471

Citation

Karamanli, Harun, et al. "Influence of Obstructive Sleep Apnea On Ischemia-modified Albumin Levels and Carotid Intima-media Thickness." Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, vol. 64, no. 5, 2016, pp. 1035-41.
Karamanli H, Kiyici A, Arik B, et al. Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness. J Investig Med. 2016;64(5):1035-41.
Karamanli, H., Kiyici, A., Arik, B., Efe, D., & Akgedik, R. (2016). Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness. Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research, 64(5), pp. 1035-41. doi:10.1136/jim-2016-000063.
Karamanli H, et al. Influence of Obstructive Sleep Apnea On Ischemia-modified Albumin Levels and Carotid Intima-media Thickness. J Investig Med. 2016;64(5):1035-41. PubMed PMID: 27029471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness. AU - Karamanli,Harun, AU - Kiyici,Aysel, AU - Arik,Bilal, AU - Efe,Duran, AU - Akgedik,Recep, Y1 - 2016/03/30/ PY - 2016/02/28/accepted PY - 2016/4/1/entrez PY - 2016/4/1/pubmed PY - 2018/1/20/medline KW - Atherosclerosis KW - Hypoxia KW - Oxidants KW - Sleep Apnea, Obstructive SP - 1035 EP - 41 JF - Journal of investigative medicine : the official publication of the American Federation for Clinical Research JO - J. Investig. Med. VL - 64 IS - 5 N2 - Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA. SN - 1708-8267 UR - https://www.unboundmedicine.com/medline/citation/27029471/Influence_of_obstructive_sleep_apnea_on_ischemia_modified_albumin_levels_and_carotid_intima_media_thickness_ L2 - http://jim.bmj.com/cgi/pmidlookup?view=long&pmid=27029471 DB - PRIME DP - Unbound Medicine ER -