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DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial.
Am J Clin Nutr 2016; 103(6):1489-96AJ

Abstract

BACKGROUND

The omega-3 (n-3) long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) has proven effective at reducing fat storage in animal studies. However, a systematic review of human trials showed a lack of quality data to support or refute this hypothesis.

OBJECTIVE

We sought to determine whether maternal DHA supplementation during the second half of pregnancy results in a lower body mass index (BMI) and percentage of body fat in children.

DESIGN

We conducted a follow-up at 3 and 5 y of age of children who were born to mothers enrolled in the DOMInO (DHA to Optimize Mother Infant Outcome) double-blind, randomized controlled trial, in which women with a singleton pregnancy were provided with DHA-rich fish-oil capsules (800 mg DHA/d) or vegetable-oil capsules (control group) in the second half of pregnancy. Primary outcomes were the BMI z score and percentage of body fat at 3 and 5 y of age. Potential interactions between prenatal DHA and the peroxisome proliferator-activated receptor-γ (PPARγ) genotype as a measure of the genetic predisposition to obesity were investigated.

RESULTS

A total of 1614 children were eligible for the follow-up. Parent or caregiver consent was obtained for 1531 children (95%), and these children were included in the analysis. BMI z scores and percentages of body fat of children in the DHA group did not differ from those of children in the control group at either 3 y of age [BMI z score adjusted mean difference: 0.03 (95% CI: -0.07, 0.13; P = 0.61); percentage of body fat adjusted mean difference: -0.26 (95% CI: -0.99, 0.46; P = 0.47)] or 5 y of age [BMI z score adjusted mean difference: 0.02 (95% CI: -0.08, 0.12; P = 0.66); percentage of body fat adjusted mean difference: 0.11 (95% CI: -0.60, 0.82; P = 0.75)]. No treatment effects were modified by the PPARγ genotype of the child.

CONCLUSION

Independent of a genetic predisposition to obesity, maternal intake of DHA-rich fish oil during the second half of pregnancy does not affect the growth or body composition of children at 3 or 5 y of age. This trial was registered at www.anzctr.org.au as ACTRN1260500056906 and ACTRN12611001127998.

Authors+Show Affiliations

Child Nutrition Research Centre, Women's and Children's Health Research Institute, Women's and Children's Hospital and Flinders Medical Centre, Adelaide, Australia; FOODplus Research Centre, Department of Wine and Food Science, School of Agriculture, Food and Wine and Schools of beverly.muhlhausler@adelaide.edu.au.Child Nutrition Research Centre, Women's and Children's Health Research Institute, Women's and Children's Hospital and Flinders Medical Centre, Adelaide, Australia; Public Health and.School of Public Health, University of South Australia, Adelaide, Australia; College of Public Health, Medical & Vet Sciences, James Cook University, Cairns, Australia;Illawarra Health and Medical Research Institute, School of Medicine, University of Wollongong, Wollongong, Australia;Women's and Children's Hospital, Adelaide, Australia; and.Child Nutrition Research Centre, Women's and Children's Health Research Institute, Women's and Children's Hospital and Flinders Medical Centre, Adelaide, Australia; FOODplus Research Centre, Department of Wine and Food Science, School of Agriculture, Food and Wine and Schools of.Child Nutrition Research Centre, Women's and Children's Health Research Institute, Women's and Children's Hospital and Flinders Medical Centre, Adelaide, Australia; Pediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

27030533

Citation

Muhlhausler, Beverly S., et al. "DHA Supplementation During Pregnancy Does Not Reduce BMI or Body Fat Mass in Children: Follow-up of the DHA to Optimize Mother Infant Outcome Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 103, no. 6, 2016, pp. 1489-96.
Muhlhausler BS, Yelland LN, McDermott R, et al. DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial. Am J Clin Nutr. 2016;103(6):1489-96.
Muhlhausler, B. S., Yelland, L. N., McDermott, R., Tapsell, L., McPhee, A., Gibson, R. A., & Makrides, M. (2016). DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial. The American Journal of Clinical Nutrition, 103(6), pp. 1489-96. doi:10.3945/ajcn.115.126714.
Muhlhausler BS, et al. DHA Supplementation During Pregnancy Does Not Reduce BMI or Body Fat Mass in Children: Follow-up of the DHA to Optimize Mother Infant Outcome Randomized Controlled Trial. Am J Clin Nutr. 2016;103(6):1489-96. PubMed PMID: 27030533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial. AU - Muhlhausler,Beverly S, AU - Yelland,Lisa N, AU - McDermott,Robyn, AU - Tapsell,Linda, AU - McPhee,Andrew, AU - Gibson,Robert A, AU - Makrides,Maria, Y1 - 2016/03/30/ PY - 2015/11/02/received PY - 2016/03/01/accepted PY - 2016/4/1/entrez PY - 2016/4/1/pubmed PY - 2017/5/27/medline KW - body composition KW - growth KW - maternal nutrition KW - omega-3 KW - pregnancy SP - 1489 EP - 96 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 103 IS - 6 N2 - BACKGROUND: The omega-3 (n-3) long-chain polyunsaturated fatty acid (LCPUFA) docosahexaenoic acid (DHA) has proven effective at reducing fat storage in animal studies. However, a systematic review of human trials showed a lack of quality data to support or refute this hypothesis. OBJECTIVE: We sought to determine whether maternal DHA supplementation during the second half of pregnancy results in a lower body mass index (BMI) and percentage of body fat in children. DESIGN: We conducted a follow-up at 3 and 5 y of age of children who were born to mothers enrolled in the DOMInO (DHA to Optimize Mother Infant Outcome) double-blind, randomized controlled trial, in which women with a singleton pregnancy were provided with DHA-rich fish-oil capsules (800 mg DHA/d) or vegetable-oil capsules (control group) in the second half of pregnancy. Primary outcomes were the BMI z score and percentage of body fat at 3 and 5 y of age. Potential interactions between prenatal DHA and the peroxisome proliferator-activated receptor-γ (PPARγ) genotype as a measure of the genetic predisposition to obesity were investigated. RESULTS: A total of 1614 children were eligible for the follow-up. Parent or caregiver consent was obtained for 1531 children (95%), and these children were included in the analysis. BMI z scores and percentages of body fat of children in the DHA group did not differ from those of children in the control group at either 3 y of age [BMI z score adjusted mean difference: 0.03 (95% CI: -0.07, 0.13; P = 0.61); percentage of body fat adjusted mean difference: -0.26 (95% CI: -0.99, 0.46; P = 0.47)] or 5 y of age [BMI z score adjusted mean difference: 0.02 (95% CI: -0.08, 0.12; P = 0.66); percentage of body fat adjusted mean difference: 0.11 (95% CI: -0.60, 0.82; P = 0.75)]. No treatment effects were modified by the PPARγ genotype of the child. CONCLUSION: Independent of a genetic predisposition to obesity, maternal intake of DHA-rich fish oil during the second half of pregnancy does not affect the growth or body composition of children at 3 or 5 y of age. This trial was registered at www.anzctr.org.au as ACTRN1260500056906 and ACTRN12611001127998. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/27030533/DHA_supplementation_during_pregnancy_does_not_reduce_BMI_or_body_fat_mass_in_children:_follow_up_of_the_DHA_to_Optimize_Mother_Infant_Outcome_randomized_controlled_trial_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.115.126714 DB - PRIME DP - Unbound Medicine ER -