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Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats.
Physiol Int. 2016 Mar; 103(1):13-20.PI

Abstract

The vasodilatory effect of angiotensin 1-7 (Ang 1-7) is exerted in the vascular bed via Mas receptor (MasR) gender dependently. However, the crosstalk between MasR and angiotensin II (Ang II) types 1 and 2 receptors (AT1R and AT2R) may change some actions of Ang 1-7 in renal circulation. In this study by blocking AT1R and AT2R, the role of MasR in kidney hemodynamics was described. In anaesthetized male and female Wistar rats, the effects of saline as vehicle and MasR blockade (A779) were tested on mean arterial pressure (MAP), renal perfusion pressure (RPP), renal blood flow (RBF), and renal vascular resistance (RVR) when both AT1R and AT2R were blocked by losartan and PD123319, respectively. In male rats, when AT1R and AT2R were blocked, there was a tendency for the increase in RBF/wet kidney tissue weight (RBF/KW) to be elevated by A779 as compared with the vehicle (P=0.08), and this was not the case in female rats. The impact of MasR on renal hemodynamics appears not to be sexual dimorphism either when Ang II receptors were blocked. It seems that co-blockade of all AT1R, AT2R, and MasR may alter RBF/ KW in male more than in female rats. These findings support a crosstalk between MasR and Ang II receptors in renal circulation.

Authors+Show Affiliations

Water and Electrolytes Research Center, Isfahan University of Medical Sciences , Isfahan , Iran. Department of Biology, University of Kharazmi , Tehran , Iran.Department of Biology, University of Kharazmi , Tehran , Iran.Water and Electrolytes Research Center, Isfahan University of Medical Sciences , Isfahan , Iran. Isfahan MN Institute of Basic and Applied Sciences Research , Isfahan , Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27030624

Citation

Mansoori, A, et al. "Role of Mas Receptor Antagonist (A779) in Renal Hemodynamics in Condition of Blocked Angiotensin II Receptors in Rats." Physiology International, vol. 103, no. 1, 2016, pp. 13-20.
Mansoori A, Oryan S, Nematbakhsh M. Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats. Physiol Int. 2016;103(1):13-20.
Mansoori, A., Oryan, S., & Nematbakhsh, M. (2016). Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats. Physiology International, 103(1), 13-20. https://doi.org/10.1556/036.103.2016.1.2
Mansoori A, Oryan S, Nematbakhsh M. Role of Mas Receptor Antagonist (A779) in Renal Hemodynamics in Condition of Blocked Angiotensin II Receptors in Rats. Physiol Int. 2016;103(1):13-20. PubMed PMID: 27030624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats. AU - Mansoori,A, AU - Oryan,S, AU - Nematbakhsh,M, PY - 2016/4/1/entrez PY - 2016/4/1/pubmed PY - 2016/6/9/medline KW - angiotensin (1–7) receptor KW - angiotensin type 1 and 2 receptors KW - renal blood flow KW - renin angiotensin system (RAS) SP - 13 EP - 20 JF - Physiology international JO - Physiol Int VL - 103 IS - 1 N2 - The vasodilatory effect of angiotensin 1-7 (Ang 1-7) is exerted in the vascular bed via Mas receptor (MasR) gender dependently. However, the crosstalk between MasR and angiotensin II (Ang II) types 1 and 2 receptors (AT1R and AT2R) may change some actions of Ang 1-7 in renal circulation. In this study by blocking AT1R and AT2R, the role of MasR in kidney hemodynamics was described. In anaesthetized male and female Wistar rats, the effects of saline as vehicle and MasR blockade (A779) were tested on mean arterial pressure (MAP), renal perfusion pressure (RPP), renal blood flow (RBF), and renal vascular resistance (RVR) when both AT1R and AT2R were blocked by losartan and PD123319, respectively. In male rats, when AT1R and AT2R were blocked, there was a tendency for the increase in RBF/wet kidney tissue weight (RBF/KW) to be elevated by A779 as compared with the vehicle (P=0.08), and this was not the case in female rats. The impact of MasR on renal hemodynamics appears not to be sexual dimorphism either when Ang II receptors were blocked. It seems that co-blockade of all AT1R, AT2R, and MasR may alter RBF/ KW in male more than in female rats. These findings support a crosstalk between MasR and Ang II receptors in renal circulation. SN - 2498-602X UR - https://www.unboundmedicine.com/medline/citation/27030624/Role_of_Mas_receptor_antagonist__A779__in_renal_hemodynamics_in_condition_of_blocked_angiotensin_II_receptors_in_rats_ L2 - https://akjournals.com/doi/10.1556/036.103.2016.1.2 DB - PRIME DP - Unbound Medicine ER -