Tags

Type your tag names separated by a space and hit enter

Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ε4 on memory decline in older adults.

Abstract

Apolipoprotein ε4 (ApoE4) is a strong genetic risk factor for sporadic Alzheimer's disease and memory decline in older adults. A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer's disease. As both genes regulate cholesterol, we hypothesized that the favorable CETPV405 allele may buffer the effect of ApoE4 on memory decline in older adults. Using linear regression, we examined the interactive effect of ApoE4 by CETPV405 on memory decline among 909 community-dwelling, nondemented, older adults (≥70 years) from the Einstein Aging Study. Episodic memory was measured using the picture version of the Free and Cued Selective Reminding Test with immediate recall (pFCSRT+IR). There was a significant ApoE × CETP interaction on decline in pFCSRT+IR scores (p = 0.01). ApoE4 carriers experienced faster decline than noncarriers among CETPI405I homozygotes (p = 0.007) and in CETPI405V heterozygotes (p = 0.015) but not in CETPV405V homozygotes (p = 0.614). Results suggest that the CETPV405 allele buffers ApoE4-associated memory decline in a gene dose-dependent manner.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: erin.sundermann@einstein.yu.edu.

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Psychology, Fordham University, Bronx, NY, USA.

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

    ,

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

    ,

    Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.

    Einstein Aging Study and the Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

    Source

    Neurobiology of aging 41: 2016 May pg 200.e7-200.e12

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Apolipoproteins E
    Cholesterol Ester Transfer Proteins
    Epistasis, Genetic
    Female
    Gene Dosage
    Heterozygote
    Homozygote
    Humans
    Male
    Memory Disorders
    Memory, Episodic
    Polymorphism, Single Nucleotide
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    27033407

    Citation

    Sundermann, Erin Elizabeth, et al. "Cholesteryl Ester Transfer Protein Genotype Modifies the Effect of Apolipoprotein Ε4 On Memory Decline in Older Adults." Neurobiology of Aging, vol. 41, 2016, pp. 200.e7-200.e12.
    Sundermann EE, Wang C, Katz M, et al. Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ε4 on memory decline in older adults. Neurobiol Aging. 2016;41:200.e7-200.e12.
    Sundermann, E. E., Wang, C., Katz, M., Zimmerman, M. E., Derby, C. A., Hall, C. B., ... Lipton, R. B. (2016). Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ε4 on memory decline in older adults. Neurobiology of Aging, 41, pp. 200.e7-200.e12. doi:10.1016/j.neurobiolaging.2016.02.006.
    Sundermann EE, et al. Cholesteryl Ester Transfer Protein Genotype Modifies the Effect of Apolipoprotein Ε4 On Memory Decline in Older Adults. Neurobiol Aging. 2016;41:200.e7-200.e12. PubMed PMID: 27033407.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ε4 on memory decline in older adults. AU - Sundermann,Erin Elizabeth, AU - Wang,Cuiling, AU - Katz,Mindy, AU - Zimmerman,Molly E, AU - Derby,Carol A, AU - Hall,Charles B, AU - Ozelius,Laurie J, AU - Lipton,Richard B, Y1 - 2016/02/16/ PY - 2015/07/16/received PY - 2016/01/27/revised PY - 2016/02/07/accepted PY - 2016/4/2/entrez PY - 2016/4/2/pubmed PY - 2016/12/16/medline KW - ApoE ε4 KW - CETP KW - Gene–gene interaction KW - I405V KW - Memory decline SP - 200.e7 EP - 200.e12 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 41 N2 - Apolipoprotein ε4 (ApoE4) is a strong genetic risk factor for sporadic Alzheimer's disease and memory decline in older adults. A single-nucleotide polymorphism in the cholesteryl ester transfer protein (CETP) gene (isoleucine to valine; V405) is associated with slower memory decline and a lower risk of Alzheimer's disease. As both genes regulate cholesterol, we hypothesized that the favorable CETPV405 allele may buffer the effect of ApoE4 on memory decline in older adults. Using linear regression, we examined the interactive effect of ApoE4 by CETPV405 on memory decline among 909 community-dwelling, nondemented, older adults (≥70 years) from the Einstein Aging Study. Episodic memory was measured using the picture version of the Free and Cued Selective Reminding Test with immediate recall (pFCSRT+IR). There was a significant ApoE × CETP interaction on decline in pFCSRT+IR scores (p = 0.01). ApoE4 carriers experienced faster decline than noncarriers among CETPI405I homozygotes (p = 0.007) and in CETPI405V heterozygotes (p = 0.015) but not in CETPV405V homozygotes (p = 0.614). Results suggest that the CETPV405 allele buffers ApoE4-associated memory decline in a gene dose-dependent manner. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/27033407/Cholesteryl_ester_transfer_protein_genotype_modifies_the_effect_of_apolipoprotein_ε4_on_memory_decline_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(16)00149-4 DB - PRIME DP - Unbound Medicine ER -