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Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase.
Biochim Biophys Acta. 2016 Aug; 1857(8):1127-1138.BB

Abstract

Merely considered as a toxic gas in the past, hydrogen sulfide (H2S) is currently viewed as the third 'gasotransmitter' in addition to nitric oxide (NO) and carbon monoxide (CO), playing a key signalling role in human (patho)physiology. H2S can either act as a substrate or, similarly to CO and NO, an inhibitor of mitochondrial respiration, in the latter case by targeting cytochrome c oxidase (CcOX). The impact of H(2)S on mitochondrial energy metabolism crucially depends on the bioavailability of this gaseous molecule and its interplay with the other two gasotransmitters. The H(2)S-producing human enzyme cystathionine β-synthase (CBS), sustaining cellular bioenergetics in colorectal cancer cells, plays a role in the interplay between gasotransmitters. The enzyme was indeed recently shown to be negatively modulated by physiological concentrations of CO and NO, particularly in the presence of its allosteric activator S-adenosyl-l-methionine (AdoMet). These newly discovered regulatory mechanisms are herein reviewed. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Vicente JB
Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República (EAN), 2780-156 Oeiras, Portugal. Electronic address: jvicente@itqb.unl.pt.
Malagrinò F
Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
Arese M
Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
Forte E
Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
Sarti P
Department of Biochemical Sciences and Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
Giuffrè A
CNR Institute of Molecular Biology and Pathology, Piazzale Aldo Moro 5, I-00185 Rome, Italy. Electronic address: alessandro.giuffre@uniroma1.it.

MeSH

Carbon MonoxideColonic NeoplasmsCystathionine beta-SynthaseElectron Transport Complex IVGasotransmittersGene ExpressionGlutathioneHumansHydrogen SulfideKineticsMitochondriaModels, MolecularNitric OxideOxidative PhosphorylationS-AdenosylmethionineSignal Transduction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

27039165

Citation

Vicente, João B., et al. "Bioenergetic Relevance of Hydrogen Sulfide and the Interplay Between Gasotransmitters at Human Cystathionine Β-synthase." Biochimica Et Biophysica Acta, vol. 1857, no. 8, 2016, pp. 1127-1138.
Vicente JB, Malagrinò F, Arese M, et al. Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase. Biochim Biophys Acta. 2016;1857(8):1127-1138.
Vicente, J. B., Malagrinò, F., Arese, M., Forte, E., Sarti, P., & Giuffrè, A. (2016). Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase. Biochimica Et Biophysica Acta, 1857(8), 1127-1138. https://doi.org/10.1016/j.bbabio.2016.03.030
Vicente JB, et al. Bioenergetic Relevance of Hydrogen Sulfide and the Interplay Between Gasotransmitters at Human Cystathionine Β-synthase. Biochim Biophys Acta. 2016;1857(8):1127-1138. PubMed PMID: 27039165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioenergetic relevance of hydrogen sulfide and the interplay between gasotransmitters at human cystathionine β-synthase. AU - Vicente,João B, AU - Malagrinò,Francesca, AU - Arese,Marzia, AU - Forte,Elena, AU - Sarti,Paolo, AU - Giuffrè,Alessandro, Y1 - 2016/03/31/ PY - 2016/01/21/received PY - 2016/03/07/revised PY - 2016/03/28/accepted PY - 2016/4/4/entrez PY - 2016/4/4/pubmed PY - 2016/8/19/medline KW - Cystathionine β-synthase KW - Cytochrome c oxidase KW - Gasotransmitters KW - Heme chemistry KW - Mitochondrial respiration KW - Sulfide metabolism SP - 1127 EP - 1138 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1857 IS - 8 N2 - Merely considered as a toxic gas in the past, hydrogen sulfide (H2S) is currently viewed as the third 'gasotransmitter' in addition to nitric oxide (NO) and carbon monoxide (CO), playing a key signalling role in human (patho)physiology. H2S can either act as a substrate or, similarly to CO and NO, an inhibitor of mitochondrial respiration, in the latter case by targeting cytochrome c oxidase (CcOX). The impact of H(2)S on mitochondrial energy metabolism crucially depends on the bioavailability of this gaseous molecule and its interplay with the other two gasotransmitters. The H(2)S-producing human enzyme cystathionine β-synthase (CBS), sustaining cellular bioenergetics in colorectal cancer cells, plays a role in the interplay between gasotransmitters. The enzyme was indeed recently shown to be negatively modulated by physiological concentrations of CO and NO, particularly in the presence of its allosteric activator S-adenosyl-l-methionine (AdoMet). These newly discovered regulatory mechanisms are herein reviewed. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/27039165/Bioenergetic_relevance_of_hydrogen_sulfide_and_the_interplay_between_gasotransmitters_at_human_cystathionine_β_synthase_ DB - PRIME DP - Unbound Medicine ER -