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Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients with Low Baseline Cholesterol Levels.
J Atheroscler Thromb. 2016 Sep 01; 23(9):1055-66.JA

Abstract

AIM

The efficacy of statin therapy in inducing coronary plaque regression may depend on baseline cholesterol levels. We aimed to determine the efficacy of statin therapy in inducing coronary plaque regression in statin-naïve patients with low cholesterol levels using serial intravascular ultrasound (IVUS) data from the treatment with statin on atheroma regression evaluated by virtual histology IVUS (TRUTH) study.

METHODS

The TRUTH study is a prospective, multicenter trial, comparing the efficacies of pitavastatin and pravastatin in coronary plaque regression in 164 patients. All patients were statin-naïve and received statin therapy only after study enrollment. The primary endpoint was the observation of coronary plaque progression, despite statin therapy.

RESULTS

Serial IVUS data, at baseline and after an 8-month follow-up, were available for 119 patients. The patients were divided into three groups based on non-high-density lipoprotein cholesterol (HDL-C) levels-low: ≤140 mg/dl, n=38; moderate: 141-169 mg/dl, n=42; and high: ≥170 mg/dl, n=39. Coronary plaque progression was noted in the low cholesterol group, whereas plaque regression was noted in the moderate and high cholesterol groups [%Δplaque volume: 2.3±7.4 vs. -2.7± 10.7 vs. -3.2±7.5, p=0.004 (analysis of variance)]. After adjusting for all variables, a low non-HDL-C level (≤140 mg/dl) was identified as an independent predictor of coronary plaque progression [odds ratio, 3.7; 95% confidence interval, 1.5-9.1, p=0.004].

CONCLUSION

Serial IVUS data analysis indicated that statin therapy was less effective in inducing coronary plaque regression in patients with low cholesterol levels but more effective in those with high cholesterol levels at baseline.University Hospital Medical Information Network (UMIN) (UMIN ID: C000000311).

Authors+Show Affiliations

Division of Cardiology, Showa University Fujigaoka Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

27040362

Citation

Wakabayashi, Kohei, et al. "Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients With Low Baseline Cholesterol Levels." Journal of Atherosclerosis and Thrombosis, vol. 23, no. 9, 2016, pp. 1055-66.
Wakabayashi K, Nozue T, Yamamoto S, et al. Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients with Low Baseline Cholesterol Levels. J Atheroscler Thromb. 2016;23(9):1055-66.
Wakabayashi, K., Nozue, T., Yamamoto, S., Tohyama, S., Fukui, K., Umezawa, S., Onishi, Y., Kunishima, T., Sato, A., Miyake, S., Morino, Y., Yamauchi, T., Muramatsu, T., Hibi, K., Terashima, M., Suzuki, H., & Michishita, I. (2016). Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients with Low Baseline Cholesterol Levels. Journal of Atherosclerosis and Thrombosis, 23(9), 1055-66. https://doi.org/10.5551/jat.34660
Wakabayashi K, et al. Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients With Low Baseline Cholesterol Levels. J Atheroscler Thromb. 2016 Sep 1;23(9):1055-66. PubMed PMID: 27040362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of Statin Therapy in Inducing Coronary Plaque Regression in Patients with Low Baseline Cholesterol Levels. AU - Wakabayashi,Kohei, AU - Nozue,Tsuyoshi, AU - Yamamoto,Shingo, AU - Tohyama,Shinichi, AU - Fukui,Kazuki, AU - Umezawa,Shigeo, AU - Onishi,Yuko, AU - Kunishima,Tomoyuki, AU - Sato,Akira, AU - Miyake,Shogo, AU - Morino,Yoshihiro, AU - Yamauchi,Takao, AU - Muramatsu,Toshiya, AU - Hibi,Kiyoshi, AU - Terashima,Mitsuyasu, AU - Suzuki,Hiroshi, AU - Michishita,Ichiro, AU - ,, Y1 - 2016/03/31/ PY - 2016/4/5/entrez PY - 2016/4/5/pubmed PY - 2017/4/19/medline SP - 1055 EP - 66 JF - Journal of atherosclerosis and thrombosis JO - J Atheroscler Thromb VL - 23 IS - 9 N2 - AIM: The efficacy of statin therapy in inducing coronary plaque regression may depend on baseline cholesterol levels. We aimed to determine the efficacy of statin therapy in inducing coronary plaque regression in statin-naïve patients with low cholesterol levels using serial intravascular ultrasound (IVUS) data from the treatment with statin on atheroma regression evaluated by virtual histology IVUS (TRUTH) study. METHODS: The TRUTH study is a prospective, multicenter trial, comparing the efficacies of pitavastatin and pravastatin in coronary plaque regression in 164 patients. All patients were statin-naïve and received statin therapy only after study enrollment. The primary endpoint was the observation of coronary plaque progression, despite statin therapy. RESULTS: Serial IVUS data, at baseline and after an 8-month follow-up, were available for 119 patients. The patients were divided into three groups based on non-high-density lipoprotein cholesterol (HDL-C) levels-low: ≤140 mg/dl, n=38; moderate: 141-169 mg/dl, n=42; and high: ≥170 mg/dl, n=39. Coronary plaque progression was noted in the low cholesterol group, whereas plaque regression was noted in the moderate and high cholesterol groups [%Δplaque volume: 2.3±7.4 vs. -2.7± 10.7 vs. -3.2±7.5, p=0.004 (analysis of variance)]. After adjusting for all variables, a low non-HDL-C level (≤140 mg/dl) was identified as an independent predictor of coronary plaque progression [odds ratio, 3.7; 95% confidence interval, 1.5-9.1, p=0.004]. CONCLUSION: Serial IVUS data analysis indicated that statin therapy was less effective in inducing coronary plaque regression in patients with low cholesterol levels but more effective in those with high cholesterol levels at baseline.University Hospital Medical Information Network (UMIN) (UMIN ID: C000000311). SN - 1880-3873 UR - https://www.unboundmedicine.com/medline/citation/27040362/Efficacy_of_Statin_Therapy_in_Inducing_Coronary_Plaque_Regression_in_Patients_with_Low_Baseline_Cholesterol_Levels_ L2 - https://dx.doi.org/10.5551/jat.34660 DB - PRIME DP - Unbound Medicine ER -