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The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice.
Eur J Pharmacol. 2016 Jun 15; 781:45-52.EJ

Abstract

Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice. Pre-training administration of ketamine (5, 10 and 15mg/kg, i.p.) dose-dependently decreased the memory acquisition of a one-trial passive avoidance task. Pre-training intra-mPFC administration of SKF 38393, D1 receptor agonist and quinpirol D2 receptor agonist, alone did not affect memory acquisition. However, amnesia induced by pre-training ketamine (15mg/kg) significantly decreased by pretreatment of SKF 38393 (2 and 4µg/mouse) and quinpirol (0.3, 1 and 3µg/mouse). Pre-training administration of SCH 23390, D1 receptor antagonist (0.75 and 1μg/mouse, intra-mPFC), and sulpiride D2 receptor antagonist (3μg/mouse, intra-mPFC) impaired memory acquisition. In addition, co-pretreatment of different doses of SCH 23390 and sulpiride with lower dose of ketamine (5mg/kg), which did not induce amnesia by itself, caused inhibition of memory formation. It may be concluded that dopaminergic system of medial prefrontal cortex is involved in the ketamine-induced impairment of memory acquisition.

Authors+Show Affiliations

Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Basic Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Garmsar branch, Semnan, Iran.Department of Neuroscience, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran; Iranian National Center for Addiction Studies, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran; Institute for Cognitive Science Studies (ICSS), Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Electronic address: zarinmr@ams.ac.ir.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27041647

Citation

Farahmandfar, Maryam, et al. "The Influence of Dopaminergic System in Medial Prefrontal Cortex On Ketamine-induced Amnesia in Passive Avoidance Task in Mice." European Journal of Pharmacology, vol. 781, 2016, pp. 45-52.
Farahmandfar M, Bakhtazad A, Akbarabadi A, et al. The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. Eur J Pharmacol. 2016;781:45-52.
Farahmandfar, M., Bakhtazad, A., Akbarabadi, A., & Zarrindast, M. R. (2016). The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. European Journal of Pharmacology, 781, 45-52. https://doi.org/10.1016/j.ejphar.2016.03.060
Farahmandfar M, et al. The Influence of Dopaminergic System in Medial Prefrontal Cortex On Ketamine-induced Amnesia in Passive Avoidance Task in Mice. Eur J Pharmacol. 2016 Jun 15;781:45-52. PubMed PMID: 27041647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice. AU - Farahmandfar,Maryam, AU - Bakhtazad,Atefeh, AU - Akbarabadi,Ardeshir, AU - Zarrindast,Mohammad-Reza, Y1 - 2016/04/01/ PY - 2015/06/25/received PY - 2016/03/26/revised PY - 2016/03/31/accepted PY - 2016/4/5/entrez PY - 2016/4/5/pubmed PY - 2017/3/9/medline KW - Dopaminergic system KW - Ketamine KW - Medial prefrontal cortex KW - Mice KW - Passive avoidance SP - 45 EP - 52 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 781 N2 - Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice. Pre-training administration of ketamine (5, 10 and 15mg/kg, i.p.) dose-dependently decreased the memory acquisition of a one-trial passive avoidance task. Pre-training intra-mPFC administration of SKF 38393, D1 receptor agonist and quinpirol D2 receptor agonist, alone did not affect memory acquisition. However, amnesia induced by pre-training ketamine (15mg/kg) significantly decreased by pretreatment of SKF 38393 (2 and 4µg/mouse) and quinpirol (0.3, 1 and 3µg/mouse). Pre-training administration of SCH 23390, D1 receptor antagonist (0.75 and 1μg/mouse, intra-mPFC), and sulpiride D2 receptor antagonist (3μg/mouse, intra-mPFC) impaired memory acquisition. In addition, co-pretreatment of different doses of SCH 23390 and sulpiride with lower dose of ketamine (5mg/kg), which did not induce amnesia by itself, caused inhibition of memory formation. It may be concluded that dopaminergic system of medial prefrontal cortex is involved in the ketamine-induced impairment of memory acquisition. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/27041647/The_influence_of_dopaminergic_system_in_medial_prefrontal_cortex_on_ketamine_induced_amnesia_in_passive_avoidance_task_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(16)30199-6 DB - PRIME DP - Unbound Medicine ER -