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The effect of binary mixtures of zinc, copper, cadmium, and nickel on the growth of the freshwater diatom Navicula pelliculosa and comparison with mixture toxicity model predictions.
Environ Toxicol Chem. 2016 11; 35(11):2765-2773.ET

Abstract

The authors investigated the effect of binary mixtures of zinc (Zn), copper (Cu), cadmium (Cd), and nickel (Ni) on the growth of a freshwater diatom, Navicula pelliculosa. A 7 × 7 full factorial experimental design (49 combinations in total) was used to test each binary metal mixture. A 3-d fluorescence microplate toxicity assay was used to test each combination. Mixture effects were predicted by concentration addition and independent action models based on a single-metal concentration-response relationship between the relative growth rate and the calculated free metal ion activity. Although the concentration addition model predicted the observed mixture toxicity significantly better than the independent action model for the Zn-Cu mixture, the independent action model predicted the observed mixture toxicity significantly better than the concentration addition model for the Cd-Zn, Cd-Ni, and Cd-Cu mixtures. For the Zn-Ni and Cu-Ni mixtures, it was unclear which of the 2 models was better. Statistical analysis concerning antagonistic/synergistic interactions showed that the concentration addition model is generally conservative (with the Zn-Ni mixture being the sole exception), indicating that the concentration addition model would be useful as a method for a conservative first-tier screening-level risk analysis of metal mixtures. Environ Toxicol Chem 2016;35:2765-2773. © 2016 SETAC.

Authors+Show Affiliations

National Institute for Agro-Environmental Sciences, Tsukuba, Ibaraki, Japan. nagait@affrc.go.jp. Laboratory of Environmental Toxicology and Aquatic Ecology, Environmental Toxicology Unit (GhEnToxLab), Ghent University, Ghent, Belgium. nagait@affrc.go.jp.Laboratory of Environmental Toxicology and Aquatic Ecology, Environmental Toxicology Unit (GhEnToxLab), Ghent University, Ghent, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27043471

Citation

Nagai, Takashi, and Karel A C. De Schamphelaere. "The Effect of Binary Mixtures of Zinc, Copper, Cadmium, and Nickel On the Growth of the Freshwater Diatom Navicula Pelliculosa and Comparison With Mixture Toxicity Model Predictions." Environmental Toxicology and Chemistry, vol. 35, no. 11, 2016, pp. 2765-2773.
Nagai T, De Schamphelaere KA. The effect of binary mixtures of zinc, copper, cadmium, and nickel on the growth of the freshwater diatom Navicula pelliculosa and comparison with mixture toxicity model predictions. Environ Toxicol Chem. 2016;35(11):2765-2773.
Nagai, T., & De Schamphelaere, K. A. (2016). The effect of binary mixtures of zinc, copper, cadmium, and nickel on the growth of the freshwater diatom Navicula pelliculosa and comparison with mixture toxicity model predictions. Environmental Toxicology and Chemistry, 35(11), 2765-2773. https://doi.org/10.1002/etc.3445
Nagai T, De Schamphelaere KA. The Effect of Binary Mixtures of Zinc, Copper, Cadmium, and Nickel On the Growth of the Freshwater Diatom Navicula Pelliculosa and Comparison With Mixture Toxicity Model Predictions. Environ Toxicol Chem. 2016;35(11):2765-2773. PubMed PMID: 27043471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of binary mixtures of zinc, copper, cadmium, and nickel on the growth of the freshwater diatom Navicula pelliculosa and comparison with mixture toxicity model predictions. AU - Nagai,Takashi, AU - De Schamphelaere,Karel A C, Y1 - 2016/06/30/ PY - 2015/10/20/received PY - 2015/12/03/revised PY - 2016/03/30/accepted PY - 2016/10/26/pubmed PY - 2017/7/7/medline PY - 2016/4/5/entrez KW - Biotic ligand model KW - Concentration addition KW - Independent action KW - Metal KW - Mixture toxicology SP - 2765 EP - 2773 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 35 IS - 11 N2 - The authors investigated the effect of binary mixtures of zinc (Zn), copper (Cu), cadmium (Cd), and nickel (Ni) on the growth of a freshwater diatom, Navicula pelliculosa. A 7 × 7 full factorial experimental design (49 combinations in total) was used to test each binary metal mixture. A 3-d fluorescence microplate toxicity assay was used to test each combination. Mixture effects were predicted by concentration addition and independent action models based on a single-metal concentration-response relationship between the relative growth rate and the calculated free metal ion activity. Although the concentration addition model predicted the observed mixture toxicity significantly better than the independent action model for the Zn-Cu mixture, the independent action model predicted the observed mixture toxicity significantly better than the concentration addition model for the Cd-Zn, Cd-Ni, and Cd-Cu mixtures. For the Zn-Ni and Cu-Ni mixtures, it was unclear which of the 2 models was better. Statistical analysis concerning antagonistic/synergistic interactions showed that the concentration addition model is generally conservative (with the Zn-Ni mixture being the sole exception), indicating that the concentration addition model would be useful as a method for a conservative first-tier screening-level risk analysis of metal mixtures. Environ Toxicol Chem 2016;35:2765-2773. © 2016 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/27043471/The_effect_of_binary_mixtures_of_zinc_copper_cadmium_and_nickel_on_the_growth_of_the_freshwater_diatom_Navicula_pelliculosa_and_comparison_with_mixture_toxicity_model_predictions_ DB - PRIME DP - Unbound Medicine ER -