Tags

Type your tag names separated by a space and hit enter

Long-term feeding of Atlantic salmon in seawater with low dietary long-chain n-3 fatty acids affects tissue status of the brain, retina and erythrocytes.
Br J Nutr. 2016 06; 115(11):1919-29.BJ

Abstract

In two long-term feeding trials in seawater, Atlantic salmon were fed EPA+DHA in graded levels, from 1·3 to 7·4 % of fatty acids (FA, 4-24 g/kg feed) combined with approximately 10 % 18 : 3n-3, at 6 and 12°C. Dietary EPA appeared to be sufficient in all diet groups, as no differences were seen in polar lipid tissue concentrations of either the brain, retina or erythrocytes. For DHA, a reduction in tissue levels was observed with low dietary supply. Effects on brain DHA at ≤1·4 % EPA+DHA of dietary FA and retina DHA at ≤2·7 % EPA+DHA of dietary FA were only observed in fish reared at 6°C, suggesting an effect of temperature, whereas tissue levels of n-6 FA increased as a response to increased dietary n-6 FA in both the brain and the retina at both temperatures. DHA levels in erythrocytes were affected by ≤2·7 % EPA+DHA at both temperatures. Therefore, DHA appears to be the limiting n-3 FA in diets where EPA and DHA are present in the ratios found in fishmeal and fish oil. To assess the physiological significance of FA differences in erythrocytes, the osmotic resistance was tested, but it did not vary between dietary groups. In conclusion, ≤2·7 % EPA+DHA of FA (≤9 g/kg feed) is not sufficient to maintain tissue DHA status in important tissues of Atlantic salmon throughout the seawater production cycle despite the presence of dietary 18 : 3n-3, and effects may be more severe at low water temperatures.

Authors+Show Affiliations

1National Institute of Seafood and Nutrition Research (NIFES),Postboks 2029,Nordnes, 5817 Bergen,Norway.1National Institute of Seafood and Nutrition Research (NIFES),Postboks 2029,Nordnes, 5817 Bergen,Norway.2Skretting ARC,Sjøhagen 3,4016 Stavanger,Norway.2Skretting ARC,Sjøhagen 3,4016 Stavanger,Norway.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27044510

Citation

Sissener, N H., et al. "Long-term Feeding of Atlantic Salmon in Seawater With Low Dietary Long-chain N-3 Fatty Acids Affects Tissue Status of the Brain, Retina and Erythrocytes." The British Journal of Nutrition, vol. 115, no. 11, 2016, pp. 1919-29.
Sissener NH, Torstensen BE, Stubhaug I, et al. Long-term feeding of Atlantic salmon in seawater with low dietary long-chain n-3 fatty acids affects tissue status of the brain, retina and erythrocytes. Br J Nutr. 2016;115(11):1919-29.
Sissener, N. H., Torstensen, B. E., Stubhaug, I., & Rosenlund, G. (2016). Long-term feeding of Atlantic salmon in seawater with low dietary long-chain n-3 fatty acids affects tissue status of the brain, retina and erythrocytes. The British Journal of Nutrition, 115(11), 1919-29. https://doi.org/10.1017/S0007114516000945
Sissener NH, et al. Long-term Feeding of Atlantic Salmon in Seawater With Low Dietary Long-chain N-3 Fatty Acids Affects Tissue Status of the Brain, Retina and Erythrocytes. Br J Nutr. 2016;115(11):1919-29. PubMed PMID: 27044510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term feeding of Atlantic salmon in seawater with low dietary long-chain n-3 fatty acids affects tissue status of the brain, retina and erythrocytes. AU - Sissener,N H, AU - Torstensen,B E, AU - Stubhaug,I, AU - Rosenlund,G, Y1 - 2016/04/05/ PY - 2016/4/6/entrez PY - 2016/4/6/pubmed PY - 2017/5/4/medline KW - ARA arachidonic acid KW - Atlantic salmon KW - Brain KW - DHA KW - EFA essential fatty acid KW - EPA KW - Erythrocytes KW - FA fatty acid KW - FM fishmeal KW - FO fish oil KW - LNA α linolenic acid KW - NL neutral lipids KW - PL polar lipids KW - Requirements KW - Retina SP - 1919 EP - 29 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 115 IS - 11 N2 - In two long-term feeding trials in seawater, Atlantic salmon were fed EPA+DHA in graded levels, from 1·3 to 7·4 % of fatty acids (FA, 4-24 g/kg feed) combined with approximately 10 % 18 : 3n-3, at 6 and 12°C. Dietary EPA appeared to be sufficient in all diet groups, as no differences were seen in polar lipid tissue concentrations of either the brain, retina or erythrocytes. For DHA, a reduction in tissue levels was observed with low dietary supply. Effects on brain DHA at ≤1·4 % EPA+DHA of dietary FA and retina DHA at ≤2·7 % EPA+DHA of dietary FA were only observed in fish reared at 6°C, suggesting an effect of temperature, whereas tissue levels of n-6 FA increased as a response to increased dietary n-6 FA in both the brain and the retina at both temperatures. DHA levels in erythrocytes were affected by ≤2·7 % EPA+DHA at both temperatures. Therefore, DHA appears to be the limiting n-3 FA in diets where EPA and DHA are present in the ratios found in fishmeal and fish oil. To assess the physiological significance of FA differences in erythrocytes, the osmotic resistance was tested, but it did not vary between dietary groups. In conclusion, ≤2·7 % EPA+DHA of FA (≤9 g/kg feed) is not sufficient to maintain tissue DHA status in important tissues of Atlantic salmon throughout the seawater production cycle despite the presence of dietary 18 : 3n-3, and effects may be more severe at low water temperatures. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/27044510/Long_term_feeding_of_Atlantic_salmon_in_seawater_with_low_dietary_long_chain_n_3_fatty_acids_affects_tissue_status_of_the_brain_retina_and_erythrocytes_ L2 - https://www.cambridge.org/core/product/identifier/S0007114516000945/type/journal_article DB - PRIME DP - Unbound Medicine ER -