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Comprehensive analysis of the clinical and urodynamic outcomes of primary tethered spinal cord before and after spinal cord untethering.
J Pediatr Urol. 2016 Oct; 12(5):285.e1-285.e5.JP

Abstract

INTRODUCTION

Primary tethered spinal cord (TSC) refers to a group of abnormalities associated with a posterior bony spinal defect that develops beneath an intact dermis and epidermis. There is relative agreement that patients with symptomatic TSC will require surgical intervention. However, it is still debatable as to how to approach asymptomatic patients with primary TSC.

OBJECTIVE

To study the clinical and urodynamic (UDS) outcomes of patients with primary TSC after spinal cord untethering (SCU).

STUDY DESIGN

Charts of patients with primary TSC between 1998 and 2010 were retrospectively reviewed. Patients that underwent before and after SCU clinical and UDS evaluation with minimum of 5-years follow-up were included. Continence status was assessed in children ≥5 years. Patients with dry intervals of ≥4 h were considered continent. Urologic and neuro-orthopedic manifestations, as well as UDS parameters, were compared before and after SCU. Categorical data were compared using Fisher-Exact test and continuous variables were compared using Wilcoxon-Signed-Rank test. A P-value <0.05 was considered significant.

RESULTS

Twenty-two patients met the inclusion criteria. The median age at time of SCU was 11.5 months (range 3-211). The median age at time of follow-up UDS after SCU was 22 months (range 9-218). The median age at time of last follow-up was 153.5 months (range 65-228). The median follow-up time was 71 months (range 60-192). A total of 14/22 patients had clinical manifestation before SCU, while 8/22 were asymptomatic and diagnosed based on magnetic resonance imaging/UDS findings. Of the symptomatic patients, 86% had symptom improvement after SCU. The UDS parameters showed statistically significant improvement in the median percentage of change of actual bladder capacity (P = 0.01), median intravesical pressure for patients with pre-operative pressure ≥40 cm/H2O at total cystometric bladder capacity (P = 0.012), and median bladder compliance at 75% bladder capacity (P = 0.01) (Table).

DISCUSSION

Tethered spinal cord syndrome (TSCS) is a clinical entity that presents with neurological, urological, and/or orthopedic symptoms caused by primary or secondary tethering of the spinal cord, which may result in ischemic damage of the neural tissue and symptom development. While some authors believe that surgical management should be reserved for symptomatic patients, others prefer prophylactic surgery to avoid possible irreversible neurological damage. The present study provides detailed discussion of the clinical and UDS outcomes for patients with primary TSC that underwent SCU.

CONCLUSION

For patients with primary TSC, spinal cord untethering is beneficial in terms of clinical and UDS outcomes. A prospective long-term study with large numbers could further highlight outcomes for this particular group of patients.

Authors+Show Affiliations

Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada; Department of Urology, College of Medicine and King Fahd Hospital of the University, University of Dammam, Saudi Arabia. Electronic address: sowayan81@gmail.com.Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada.Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada.Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada.Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada.Department of Pediatric Surgery, Division of Pediatric Urology and Neurosurgery, The Montreal Children's Hospital and McGill University Health Center, Shriners Hospital of Montréal, QC, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27049673

Citation

Alsowayan, O, et al. "Comprehensive Analysis of the Clinical and Urodynamic Outcomes of Primary Tethered Spinal Cord Before and After Spinal Cord Untethering." Journal of Pediatric Urology, vol. 12, no. 5, 2016, pp. 285.e1-285.e5.
Alsowayan O, Alzahrani A, Farmer JP, et al. Comprehensive analysis of the clinical and urodynamic outcomes of primary tethered spinal cord before and after spinal cord untethering. J Pediatr Urol. 2016;12(5):285.e1-285.e5.
Alsowayan, O., Alzahrani, A., Farmer, J. P., Capolicchio, J. P., Jednak, R., & El-Sherbiny, M. (2016). Comprehensive analysis of the clinical and urodynamic outcomes of primary tethered spinal cord before and after spinal cord untethering. Journal of Pediatric Urology, 12(5), e1-e5. https://doi.org/10.1016/j.jpurol.2016.02.012
Alsowayan O, et al. Comprehensive Analysis of the Clinical and Urodynamic Outcomes of Primary Tethered Spinal Cord Before and After Spinal Cord Untethering. J Pediatr Urol. 2016;12(5):285.e1-285.e5. PubMed PMID: 27049673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comprehensive analysis of the clinical and urodynamic outcomes of primary tethered spinal cord before and after spinal cord untethering. AU - Alsowayan,O, AU - Alzahrani,A, AU - Farmer,J-P, AU - Capolicchio,J-P, AU - Jednak,R, AU - El-Sherbiny,M, Y1 - 2016/03/15/ PY - 2015/10/06/received PY - 2016/02/23/accepted PY - 2016/4/7/pubmed PY - 2017/10/20/medline PY - 2016/4/7/entrez KW - Neural tube defect KW - Spinal dysraphism KW - Tethered spinal cord syndrome KW - Urinary bladder KW - Urodynamics SP - 285.e1 EP - 285.e5 JF - Journal of pediatric urology JO - J Pediatr Urol VL - 12 IS - 5 N2 - INTRODUCTION: Primary tethered spinal cord (TSC) refers to a group of abnormalities associated with a posterior bony spinal defect that develops beneath an intact dermis and epidermis. There is relative agreement that patients with symptomatic TSC will require surgical intervention. However, it is still debatable as to how to approach asymptomatic patients with primary TSC. OBJECTIVE: To study the clinical and urodynamic (UDS) outcomes of patients with primary TSC after spinal cord untethering (SCU). STUDY DESIGN: Charts of patients with primary TSC between 1998 and 2010 were retrospectively reviewed. Patients that underwent before and after SCU clinical and UDS evaluation with minimum of 5-years follow-up were included. Continence status was assessed in children ≥5 years. Patients with dry intervals of ≥4 h were considered continent. Urologic and neuro-orthopedic manifestations, as well as UDS parameters, were compared before and after SCU. Categorical data were compared using Fisher-Exact test and continuous variables were compared using Wilcoxon-Signed-Rank test. A P-value <0.05 was considered significant. RESULTS: Twenty-two patients met the inclusion criteria. The median age at time of SCU was 11.5 months (range 3-211). The median age at time of follow-up UDS after SCU was 22 months (range 9-218). The median age at time of last follow-up was 153.5 months (range 65-228). The median follow-up time was 71 months (range 60-192). A total of 14/22 patients had clinical manifestation before SCU, while 8/22 were asymptomatic and diagnosed based on magnetic resonance imaging/UDS findings. Of the symptomatic patients, 86% had symptom improvement after SCU. The UDS parameters showed statistically significant improvement in the median percentage of change of actual bladder capacity (P = 0.01), median intravesical pressure for patients with pre-operative pressure ≥40 cm/H2O at total cystometric bladder capacity (P = 0.012), and median bladder compliance at 75% bladder capacity (P = 0.01) (Table). DISCUSSION: Tethered spinal cord syndrome (TSCS) is a clinical entity that presents with neurological, urological, and/or orthopedic symptoms caused by primary or secondary tethering of the spinal cord, which may result in ischemic damage of the neural tissue and symptom development. While some authors believe that surgical management should be reserved for symptomatic patients, others prefer prophylactic surgery to avoid possible irreversible neurological damage. The present study provides detailed discussion of the clinical and UDS outcomes for patients with primary TSC that underwent SCU. CONCLUSION: For patients with primary TSC, spinal cord untethering is beneficial in terms of clinical and UDS outcomes. A prospective long-term study with large numbers could further highlight outcomes for this particular group of patients. SN - 1873-4898 UR - https://www.unboundmedicine.com/medline/citation/27049673/Comprehensive_analysis_of_the_clinical_and_urodynamic_outcomes_of_primary_tethered_spinal_cord_before_and_after_spinal_cord_untethering_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-5131(16)00065-6 DB - PRIME DP - Unbound Medicine ER -