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Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease.
Biomed Res Int. 2016; 2016:8761475.BR

Abstract

BACKGROUND

Our aim was to assess plasma neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of cardiovascular (CV) events in patients with chronic kidney disease (CKD) and no history of CV events.

METHODS

This was a prospective observational cohort study of 252 patients with predialysis CKD. CV events were defined as CV death, acute coronary syndrome, and hospitalization for worsening heart failure, stroke, and aortic dissection.

RESULTS

During a median follow-up period of 63 months, 36 CV events occurred. On Cox stepwise multivariate analysis, plasma NGAL and B-type natriuretic peptide (BNP) were significant predictors of CV events. Kaplan-Meier incidence rates of CV event-free survival at 5 years were 96.6%, 92.9%, 85.9%, and 61.3%, respectively, among quartiles of plasma NGAL (P < 0.0001). The C-index for the receiver-operating characteristic curves for CV events was greater when plasma NGAL was added to an established risk model (0.801, 95% CI 0.717-0.885), compared to the model without plasma NGAL (0.746, 95% CI 0.653-0.840, P = 0.021).

CONCLUSION

Elevated plasma NGAL could predict future CV events in CKD patients with no history of CV events and add incremental value to the established risk model.

Authors+Show Affiliations

Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Laboratory of Clinical Medicine, Department of Joint Research, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Laboratory of Clinical Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Division of Medical Statistics, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Cardiology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.Department of Nephrology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukakecho, Toyoakeshi, Aichi 470-1192, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27051671

Citation

Hasegawa, Midori, et al. "Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients With Chronic Kidney Disease." BioMed Research International, vol. 2016, 2016, p. 8761475.
Hasegawa M, Ishii J, Kitagawa F, et al. Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease. Biomed Res Int. 2016;2016:8761475.
Hasegawa, M., Ishii, J., Kitagawa, F., Takahashi, H., Sugiyama, K., Tada, M., Kanayama, K., Takahashi, K., Hayashi, H., Koide, S., Nakai, S., Ozaki, Y., & Yuzawa, Y. (2016). Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease. BioMed Research International, 2016, 8761475. https://doi.org/10.1155/2016/8761475
Hasegawa M, et al. Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients With Chronic Kidney Disease. Biomed Res Int. 2016;2016:8761475. PubMed PMID: 27051671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease. AU - Hasegawa,Midori, AU - Ishii,Junichi, AU - Kitagawa,Fumihiko, AU - Takahashi,Hiroshi, AU - Sugiyama,Kazuhiro, AU - Tada,Masashi, AU - Kanayama,Kyoko, AU - Takahashi,Kazuo, AU - Hayashi,Hiroki, AU - Koide,Shigehisa, AU - Nakai,Shigeru, AU - Ozaki,Yukio, AU - Yuzawa,Yukio, Y1 - 2016/03/14/ PY - 2015/08/29/received PY - 2016/02/11/revised PY - 2016/02/24/accepted PY - 2016/4/7/entrez PY - 2016/4/7/pubmed PY - 2017/1/4/medline SP - 8761475 EP - 8761475 JF - BioMed research international JO - Biomed Res Int VL - 2016 N2 - BACKGROUND: Our aim was to assess plasma neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of cardiovascular (CV) events in patients with chronic kidney disease (CKD) and no history of CV events. METHODS: This was a prospective observational cohort study of 252 patients with predialysis CKD. CV events were defined as CV death, acute coronary syndrome, and hospitalization for worsening heart failure, stroke, and aortic dissection. RESULTS: During a median follow-up period of 63 months, 36 CV events occurred. On Cox stepwise multivariate analysis, plasma NGAL and B-type natriuretic peptide (BNP) were significant predictors of CV events. Kaplan-Meier incidence rates of CV event-free survival at 5 years were 96.6%, 92.9%, 85.9%, and 61.3%, respectively, among quartiles of plasma NGAL (P < 0.0001). The C-index for the receiver-operating characteristic curves for CV events was greater when plasma NGAL was added to an established risk model (0.801, 95% CI 0.717-0.885), compared to the model without plasma NGAL (0.746, 95% CI 0.653-0.840, P = 0.021). CONCLUSION: Elevated plasma NGAL could predict future CV events in CKD patients with no history of CV events and add incremental value to the established risk model. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/27051671/Plasma_Neutrophil_Gelatinase_Associated_Lipocalin_as_a_Predictor_of_Cardiovascular_Events_in_Patients_with_Chronic_Kidney_Disease_ DB - PRIME DP - Unbound Medicine ER -