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Protective effect of resveratrol against aluminum chloride induced nephrotoxicity in rats.

Abstract

OBJECTIVES

To investigate the potential protective effect of resveratrol (RES) on aluminum chloride (AlCl3)-induced nephrotoxicity in rats.

METHODS

This experimental study was conducted from April to June 2015 at the Medical College of King Khalid University, Abha, Kingdom of Saudi Arabia. The experiments were performed on 24 male Wistar rats. The rats were randomly allocated into 4 groups; 1) group A: control rats received only normal saline, 2) group B: received RES dissolved in normal saline, 3) group C: model group and received AlCl3 dissolved in normal saline and 4) group D: RES treated group and received concomitant doses of RES+AlCl3. All treatments were administered for consecutive 40 days. After 40 days of treatments, kidney function tests, oxidative stress parameters and histopathological assay were evaluated.

RESULTS

all findings clearly showed significant deteriorations in kidney function and architectures after AlCl3 exposure. This was accompanied by increased renal oxidative stress and inflammation suggesting strong pro-oxidant activity of AlCl3 in spite of its non-redox status. Resveratrol co-treatment with AlCl3 to the rats showed significant improvement in all biochemical and histological parameters related to kidney function and structure.

CONCLUSION

The findings of the current study showed that RES pre-administration to rats ameliorates renal damage and improves renal function in AlCl3 intoxicated rats in a mechanism related to its antioxidant potential.

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  • Authors+Show Affiliations

    Department of Basic Medical Sciences, College of Medicine, King Saud bin Abduaziz University for Health Science, Riyadh, Kingdom of Saudi Arabia. E-mail. derah@ksau-hs.edu.sa.

    Source

    Saudi medical journal 37:4 2016 Apr pg 369-78

    MeSH

    Acute Kidney Injury
    Aluminum Compounds
    Animals
    Antioxidants
    Chlorides
    Creatinine
    Interleukin-6
    Male
    Oxidative Stress
    Rats
    Rats, Wistar
    Stilbenes
    Tumor Necrosis Factor-alpha
    Urea

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    27052279