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Characterization of ibuprofen microparticle and improvement of the dissolution.
Pharm Dev Technol. 2017 Feb; 22(1):63-68.PD

Abstract

The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), laser particle size analyzer, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). IBP microparticle prepared with surfactants showed a significant increase in dissolution rate (more than three times within 10 min) and an obvious decrease in mean particle size. The morphology of microparticles was obviously changed. XRD and DSC results revealed that the crystalline state of the untreated IBP and the prepared IBP microparticles were similar. The crystallinity of microparticles produced might be lightly reduced by adding surfactants in preparation process. All results showed that it was useful to prepare high dispersion microparticle by adding surfactants in the preparation process for improving the dissolution.

Authors+Show Affiliations

a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.a Laboratory of Pharmaceutical Crystal Engineering and Technology, Department of Pharmaceutical Engineering, School of Pharmacy , East China University of Science and Technology , Shanghai , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27055726

Citation

Ren, Fuzheng, et al. "Characterization of Ibuprofen Microparticle and Improvement of the Dissolution." Pharmaceutical Development and Technology, vol. 22, no. 1, 2017, pp. 63-68.
Ren F, Su J, Xiong H, et al. Characterization of ibuprofen microparticle and improvement of the dissolution. Pharm Dev Technol. 2017;22(1):63-68.
Ren, F., Su, J., Xiong, H., Tian, Y., Ren, G., & Jing, Q. (2017). Characterization of ibuprofen microparticle and improvement of the dissolution. Pharmaceutical Development and Technology, 22(1), 63-68. https://doi.org/10.3109/10837450.2016.1163386
Ren F, et al. Characterization of Ibuprofen Microparticle and Improvement of the Dissolution. Pharm Dev Technol. 2017;22(1):63-68. PubMed PMID: 27055726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of ibuprofen microparticle and improvement of the dissolution. AU - Ren,Fuzheng, AU - Su,Jianping, AU - Xiong,Hui, AU - Tian,Ying, AU - Ren,Guobin, AU - Jing,Qiufang, Y1 - 2016/04/07/ PY - 2016/4/9/pubmed PY - 2017/3/16/medline PY - 2016/4/9/entrez KW - Cremophor RH40 KW - Tween 80 KW - dissolution KW - ibuprofen KW - microparticle SP - 63 EP - 68 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 22 IS - 1 N2 - The objective of this study was to prepare ibuprofen (IBP) microparticles by pH-change method and enhance the dissolution rate in vitro. Tween80 and Cremophor RH40 were selected as stabilizers to change the microparticles morphology. The microparticles were evaluated by dissolution profiles and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), laser particle size analyzer, scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). IBP microparticle prepared with surfactants showed a significant increase in dissolution rate (more than three times within 10 min) and an obvious decrease in mean particle size. The morphology of microparticles was obviously changed. XRD and DSC results revealed that the crystalline state of the untreated IBP and the prepared IBP microparticles were similar. The crystallinity of microparticles produced might be lightly reduced by adding surfactants in preparation process. All results showed that it was useful to prepare high dispersion microparticle by adding surfactants in the preparation process for improving the dissolution. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/27055726/Characterization_of_ibuprofen_microparticle_and_improvement_of_the_dissolution_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2016.1163386 DB - PRIME DP - Unbound Medicine ER -