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[Influencing factors of visual hallucinations in patients with Parkinson's disease and its relationship with sleep disorders].
Zhonghua Yi Xue Za Zhi. 2016 Apr 05; 96(13):1016-20.ZY

Abstract

OBJECTIVE

To investigate the prevalence and influencing factors of visual hallucinations in patients with Parkinson's disease(PD), and to analyze the relationship between visual hallucinations and sleep disorders.

METHODS

We recruited 187 patients with PD(H-Y Ⅰ-Ⅲ) from outpatient department in Beijing Hospital. The patients were investigated for general information and the use of medicine. The patients were divided into visual hallucination(VH) group and non-hallucination(non-VH) group. A comparison study was conducted between two groups. We investigated the sleep disorders of PD patients according to Non Motor Symptom Quest(NMSquest) and Parkinson's disease sleep scale(PDSS). Logistic stepwise multiple regression procedures were used to determine the best predictive model of visual hallucinations in patients with PD.

RESULTS

(1) 42 cases(22.5%) of PD patients were accompanied by visual hallucinations; (2) the VH group and non-VH group had no difference in age, sex, duration of illness, the scores of Minimum Mental State Examination(MMSE) and levodopa equivalent doses (LED). The scores of Unified Parkinson's Disease Rating Scale(UPDRS) Ⅰ, the Hamilton Rating Scale for Anxiety(HAMA) and the Hamilton Rating Scale for Depression(HAMD) in VH group were significantly higher than those in non-VH group[3.5(2, 5) vs 2 (1, 3); 10(6.75, 15) vs 8(5, 11); 11(7.75, 17) vs 9(5, 13); P<0.05]; (3) the incidences of vivid dreams and REM sleep behavior disorder(RBD) in VH group were significantly higher than those in non-VH group(61.9% vs 40.7%, 71.4% vs 47.6%, P<0.05). There were no significant differences in incidences of excessive daytime sleepiness and restless legs between two groups(P>0.05). The score of PDSS in VH group was significantly lower than that in non-VH group[111(92.75, 128.25) vs 123(109, 135), P<0.05]; (4) the Logistic stepwise multiple regression revealed that vivid dreams(P=0.045) and the score of PDSS(P=0.006) were the independent influencing factors for VH in PD patients.

CONCLUSIONS

The incidence of VH in PD with H-Y staging Ⅰ-Ⅱ is 22.5%. The presence of vivid dreams and severe sleep disorder are independently associated with VH in PD.

Authors+Show Affiliations

Department of Neurology, Beijing Hospital, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

chi

PubMed ID

27055793

Citation

Wu, D D., et al. "[Influencing Factors of Visual Hallucinations in Patients With Parkinson's Disease and Its Relationship With Sleep Disorders]." Zhonghua Yi Xue Za Zhi, vol. 96, no. 13, 2016, pp. 1016-20.
Wu DD, Li SH, Jin LY, et al. [Influencing factors of visual hallucinations in patients with Parkinson's disease and its relationship with sleep disorders]. Zhonghua Yi Xue Za Zhi. 2016;96(13):1016-20.
Wu, D. D., Li, S. H., Jin, L. Y., Jin, Y., Cui, Y. Y., Zhao, H., Liu, H. J., Ma, X. X., Su, W., & Chen, H. B. (2016). [Influencing factors of visual hallucinations in patients with Parkinson's disease and its relationship with sleep disorders]. Zhonghua Yi Xue Za Zhi, 96(13), 1016-20. https://doi.org/10.3760/cma.j.issn.0376-2491.2016.13.007
Wu DD, et al. [Influencing Factors of Visual Hallucinations in Patients With Parkinson's Disease and Its Relationship With Sleep Disorders]. Zhonghua Yi Xue Za Zhi. 2016 Apr 5;96(13):1016-20. PubMed PMID: 27055793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influencing factors of visual hallucinations in patients with Parkinson's disease and its relationship with sleep disorders]. AU - Wu,D D, AU - Li,S H, AU - Jin,L Y, AU - Jin,Y, AU - Cui,Y Y, AU - Zhao,H, AU - Liu,H J, AU - Ma,X X, AU - Su,W, AU - Chen,H B, PY - 2016/4/9/entrez PY - 2016/4/9/pubmed PY - 2017/2/14/medline SP - 1016 EP - 20 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 96 IS - 13 N2 - OBJECTIVE: To investigate the prevalence and influencing factors of visual hallucinations in patients with Parkinson's disease(PD), and to analyze the relationship between visual hallucinations and sleep disorders. METHODS: We recruited 187 patients with PD(H-Y Ⅰ-Ⅲ) from outpatient department in Beijing Hospital. The patients were investigated for general information and the use of medicine. The patients were divided into visual hallucination(VH) group and non-hallucination(non-VH) group. A comparison study was conducted between two groups. We investigated the sleep disorders of PD patients according to Non Motor Symptom Quest(NMSquest) and Parkinson's disease sleep scale(PDSS). Logistic stepwise multiple regression procedures were used to determine the best predictive model of visual hallucinations in patients with PD. RESULTS: (1) 42 cases(22.5%) of PD patients were accompanied by visual hallucinations; (2) the VH group and non-VH group had no difference in age, sex, duration of illness, the scores of Minimum Mental State Examination(MMSE) and levodopa equivalent doses (LED). The scores of Unified Parkinson's Disease Rating Scale(UPDRS) Ⅰ, the Hamilton Rating Scale for Anxiety(HAMA) and the Hamilton Rating Scale for Depression(HAMD) in VH group were significantly higher than those in non-VH group[3.5(2, 5) vs 2 (1, 3); 10(6.75, 15) vs 8(5, 11); 11(7.75, 17) vs 9(5, 13); P<0.05]; (3) the incidences of vivid dreams and REM sleep behavior disorder(RBD) in VH group were significantly higher than those in non-VH group(61.9% vs 40.7%, 71.4% vs 47.6%, P<0.05). There were no significant differences in incidences of excessive daytime sleepiness and restless legs between two groups(P>0.05). The score of PDSS in VH group was significantly lower than that in non-VH group[111(92.75, 128.25) vs 123(109, 135), P<0.05]; (4) the Logistic stepwise multiple regression revealed that vivid dreams(P=0.045) and the score of PDSS(P=0.006) were the independent influencing factors for VH in PD patients. CONCLUSIONS: The incidence of VH in PD with H-Y staging Ⅰ-Ⅱ is 22.5%. The presence of vivid dreams and severe sleep disorder are independently associated with VH in PD. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/27055793/[Influencing_factors_of_visual_hallucinations_in_patients_with_Parkinson's_disease_and_its_relationship_with_sleep_disorders]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2016&amp;vol=96&amp;issue=13&amp;fpage=1016 DB - PRIME DP - Unbound Medicine ER -