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A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes.
J Clin Lipidol. 2016 Mar-Apr; 10(2):386-93.JC

Abstract

BACKGROUND

Limited data are available that evaluated the effects of combined omega-3 fatty acids and vitamin E supplementation on glucose homeostasis parameters and lipid concentrations in gestational diabetes (GDM).

OBJECTIVES

The present study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on glucose homeostasis parameters and lipid concentrations among women with GDM who were not on oral hypoglycemic agents.

METHODS

This prospective randomized, double-blind, placebo-controlled clinical trial was carried out among 60 patients with GDM. Patients were randomly allocated to take either 1000-mg omega-3 fatty acids from flaxseed oil plus 400-IU vitamin E supplements (n = 30) or placebo (n = 30) for 6 weeks. Fasting blood samples were obtained from at the beginning of the study and after 6-week intervention to quantify related variables.

RESULTS

After 6 weeks of intervention, changes in fasting plasma glucose (-11.8 ± 11.0 vs +1.5 ± 11.9 mg/dL, P < .001), serum insulin concentrations (-1.8 ± 6.9 vs +5.8 ± 12.1 μIU/mL, P = .004), homeostasis model of assessment-estimated insulin resistance (-0.8 ± 1.6 vs +1.4 ± 2.8, P = .001), homeostasis model of assessment-estimated beta cell function (-0.2 ± 27.7 vs +22.8 ± 48.2, P = .02), and quantitative insulin sensitivity check index (+0.01 ± 0.02 vs -0.01 ± 0.02, P = .01) in the omega-3 fatty acids plus vitamin E group were significantly different from the changes in these indicators in the placebo group. Changes in serum triglycerides (+10.8 ± 41.5 vs +34.2 ± 35.5 mg/dL, P = .02), VLDL-cholesterol (+2.1 ± 8.3 vs +6.8 ± 7.1 mg/dL, P = .02), low-density lipoprotein (LDL)-cholesterol (+11.6 ± 18.8 vs +1.7 ± 15.9 mg/dL, P = .03) and HDL-cholesterol concentrations (+1.9 ± 8.7 vs -2.4 ± 7.7 mg/dL, P = .04) were significantly different between the supplemented women and placebo group. However, after controlling for baseline total cholesterol levels, maternal age, and BMI at baseline, the changes in serum LDL-cholesterol concentrations were not significantly different between the 2 groups. We did not find any significant effect of joint omega-3 fatty acids and vitamin E supplementation on total cholesterol concentrations.

CONCLUSIONS

Overall, we demonstrated that omega-3 fatty acids and vitamin E co-supplementation in GDM women had beneficial effects on glucose homeostasis parameters, serum triglycerides, VLDL-cholesterol, and HDL-cholesterol concentrations, but it did not influence total-cholesterol and LDL-cholesterol levels.

Authors+Show Affiliations

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.Endocrinology and Metabolism Research Center, Arak University of Medical Sciences, Arak, Iran; Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran.Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran. Electronic address: asemi_r@yahoo.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27055970

Citation

Taghizadeh, Mohsen, et al. "A Randomized-controlled Clinical Trial Investigating the Effect of Omega-3 Fatty Acids and Vitamin E Co-supplementation On Markers of Insulin Metabolism and Lipid Profiles in Gestational Diabetes." Journal of Clinical Lipidology, vol. 10, no. 2, 2016, pp. 386-93.
Taghizadeh M, Jamilian M, Mazloomi M, et al. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J Clin Lipidol. 2016;10(2):386-93.
Taghizadeh, M., Jamilian, M., Mazloomi, M., Sanami, M., & Asemi, Z. (2016). A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. Journal of Clinical Lipidology, 10(2), 386-93. https://doi.org/10.1016/j.jacl.2015.12.017
Taghizadeh M, et al. A Randomized-controlled Clinical Trial Investigating the Effect of Omega-3 Fatty Acids and Vitamin E Co-supplementation On Markers of Insulin Metabolism and Lipid Profiles in Gestational Diabetes. J Clin Lipidol. 2016 Mar-Apr;10(2):386-93. PubMed PMID: 27055970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. AU - Taghizadeh,Mohsen, AU - Jamilian,Mehri, AU - Mazloomi,Maryam, AU - Sanami,Marzieh, AU - Asemi,Zatollah, Y1 - 2015/12/29/ PY - 2015/10/13/received PY - 2015/12/02/revised PY - 2015/12/21/accepted PY - 2016/4/9/entrez PY - 2016/4/9/pubmed PY - 2016/12/15/medline KW - Gestational diabetes KW - Omega-3 fatty acids KW - Pregnant women KW - Supplementation KW - Vitamin E SP - 386 EP - 93 JF - Journal of clinical lipidology JO - J Clin Lipidol VL - 10 IS - 2 N2 - BACKGROUND: Limited data are available that evaluated the effects of combined omega-3 fatty acids and vitamin E supplementation on glucose homeostasis parameters and lipid concentrations in gestational diabetes (GDM). OBJECTIVES: The present study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on glucose homeostasis parameters and lipid concentrations among women with GDM who were not on oral hypoglycemic agents. METHODS: This prospective randomized, double-blind, placebo-controlled clinical trial was carried out among 60 patients with GDM. Patients were randomly allocated to take either 1000-mg omega-3 fatty acids from flaxseed oil plus 400-IU vitamin E supplements (n = 30) or placebo (n = 30) for 6 weeks. Fasting blood samples were obtained from at the beginning of the study and after 6-week intervention to quantify related variables. RESULTS: After 6 weeks of intervention, changes in fasting plasma glucose (-11.8 ± 11.0 vs +1.5 ± 11.9 mg/dL, P < .001), serum insulin concentrations (-1.8 ± 6.9 vs +5.8 ± 12.1 μIU/mL, P = .004), homeostasis model of assessment-estimated insulin resistance (-0.8 ± 1.6 vs +1.4 ± 2.8, P = .001), homeostasis model of assessment-estimated beta cell function (-0.2 ± 27.7 vs +22.8 ± 48.2, P = .02), and quantitative insulin sensitivity check index (+0.01 ± 0.02 vs -0.01 ± 0.02, P = .01) in the omega-3 fatty acids plus vitamin E group were significantly different from the changes in these indicators in the placebo group. Changes in serum triglycerides (+10.8 ± 41.5 vs +34.2 ± 35.5 mg/dL, P = .02), VLDL-cholesterol (+2.1 ± 8.3 vs +6.8 ± 7.1 mg/dL, P = .02), low-density lipoprotein (LDL)-cholesterol (+11.6 ± 18.8 vs +1.7 ± 15.9 mg/dL, P = .03) and HDL-cholesterol concentrations (+1.9 ± 8.7 vs -2.4 ± 7.7 mg/dL, P = .04) were significantly different between the supplemented women and placebo group. However, after controlling for baseline total cholesterol levels, maternal age, and BMI at baseline, the changes in serum LDL-cholesterol concentrations were not significantly different between the 2 groups. We did not find any significant effect of joint omega-3 fatty acids and vitamin E supplementation on total cholesterol concentrations. CONCLUSIONS: Overall, we demonstrated that omega-3 fatty acids and vitamin E co-supplementation in GDM women had beneficial effects on glucose homeostasis parameters, serum triglycerides, VLDL-cholesterol, and HDL-cholesterol concentrations, but it did not influence total-cholesterol and LDL-cholesterol levels. SN - 1933-2874 UR - https://www.unboundmedicine.com/medline/citation/27055970/A_randomized_controlled_clinical_trial_investigating_the_effect_of_omega_3_fatty_acids_and_vitamin_E_co_supplementation_on_markers_of_insulin_metabolism_and_lipid_profiles_in_gestational_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1933-2874(15)30059-3 DB - PRIME DP - Unbound Medicine ER -