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Treatment principles of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis.
Arch Gynecol Obstet. 2016 09; 294(3):623-9.AG

Abstract

PURPOSE

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered paraneoplastic limbic encephalitis. Ovarian teratoma is the only tumor clearly related to anti-NMDAR encephalitis occurrence. This study aimed to assess ovarian teratoma for neurological and mental symptoms highly related with anti-NMDAR encephalitis, treatment principles, and prognosis.

METHODS

Between June 2011 and October 2014, in Peking Union Medical College Hospital, ten patients with ovarian teratoma associated with anti-NMDAR encephalitis were enrolled. All patients underwent laparoscopic oophorocystectomy followed by immunotherapy.

RESULTS

In nine patients, mental and neurological symptoms were significantly relieved 13.7 ± 5.5 days after surgery; however, symptoms persisted in one patient, who was still hospitalized when writing this paper. During the postoperative follow-up period, seven patients showed no mental symptoms or tumor recurrence; one subject had symptom recurrence 28 days after surgery, while another patient showed suspected tumor recurrence 273 days after operation.

CONCLUSIONS

Ovarian teratoma associated with anti-NMDAR encephalitis is usually associated with neurological and mental symptoms at onset. Its manifestations are complex, and nursing care is difficult. Laparoscopic oophorocystectomy followed by immunotherapy led to symptom resolution in most patients.

Authors+Show Affiliations

Peking Union Medical College Hospital, Beijing, 100730, China.Peking Union Medical College Hospital, Beijing, 100730, China.Peking Union Medical College Hospital, Beijing, 100730, China.Peking Union Medical College Hospital, Beijing, 100730, China. zhangzhiyuan0904@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27056053

Citation

Bai, Ying, et al. "Treatment Principles of Ovarian Teratoma With anti-N-methyl-D-aspartate Receptor Encephalitis." Archives of Gynecology and Obstetrics, vol. 294, no. 3, 2016, pp. 623-9.
Bai Y, Guan Q, Jiang J, et al. Treatment principles of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis. Arch Gynecol Obstet. 2016;294(3):623-9.
Bai, Y., Guan, Q., Jiang, J., & Zhang, Z. (2016). Treatment principles of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis. Archives of Gynecology and Obstetrics, 294(3), 623-9. https://doi.org/10.1007/s00404-016-4050-9
Bai Y, et al. Treatment Principles of Ovarian Teratoma With anti-N-methyl-D-aspartate Receptor Encephalitis. Arch Gynecol Obstet. 2016;294(3):623-9. PubMed PMID: 27056053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment principles of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis. AU - Bai,Ying, AU - Guan,Qiyun, AU - Jiang,Jinting, AU - Zhang,Zhiyuan, Y1 - 2016/04/07/ PY - 2015/09/17/received PY - 2016/02/11/accepted PY - 2016/4/9/entrez PY - 2016/4/9/pubmed PY - 2017/9/20/medline KW - Anti-NMDAR encephalitis KW - Epileptic nursing care KW - Immunization therapy KW - Laparoscopic perioperative care KW - Ovarian teratoma SP - 623 EP - 9 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 294 IS - 3 N2 - PURPOSE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently discovered paraneoplastic limbic encephalitis. Ovarian teratoma is the only tumor clearly related to anti-NMDAR encephalitis occurrence. This study aimed to assess ovarian teratoma for neurological and mental symptoms highly related with anti-NMDAR encephalitis, treatment principles, and prognosis. METHODS: Between June 2011 and October 2014, in Peking Union Medical College Hospital, ten patients with ovarian teratoma associated with anti-NMDAR encephalitis were enrolled. All patients underwent laparoscopic oophorocystectomy followed by immunotherapy. RESULTS: In nine patients, mental and neurological symptoms were significantly relieved 13.7 ± 5.5 days after surgery; however, symptoms persisted in one patient, who was still hospitalized when writing this paper. During the postoperative follow-up period, seven patients showed no mental symptoms or tumor recurrence; one subject had symptom recurrence 28 days after surgery, while another patient showed suspected tumor recurrence 273 days after operation. CONCLUSIONS: Ovarian teratoma associated with anti-NMDAR encephalitis is usually associated with neurological and mental symptoms at onset. Its manifestations are complex, and nursing care is difficult. Laparoscopic oophorocystectomy followed by immunotherapy led to symptom resolution in most patients. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/27056053/Treatment_principles_of_ovarian_teratoma_with_anti_N_methyl_D_aspartate_receptor_encephalitis_ L2 - https://dx.doi.org/10.1007/s00404-016-4050-9 DB - PRIME DP - Unbound Medicine ER -