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Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction.
J Am Coll Cardiol. 2016 Apr 12; 67(14):1687-97.JACC

Abstract

BACKGROUND

There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI).

OBJECTIVES

This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, including the entire spectrum of estimated glomerular filtration rates.

METHODS

This study evaluated discharge and continuous follow-up data on ACEI/ARB use among AMI survivors (2006 to 2009) included in a large Swedish registry. The association between ACEI/ARB treatment and outcomes (mortality, myocardial infarction, stroke, and acute kidney injury [AKI]) was studied using Cox proportional hazards models (intention-to-treat and as treated).

RESULTS

In total, 45,697 patients (71%) were treated with ACEI/ARB. The 3-year mortality was 19.8% (17.4% of ACEI/ARB users and 25.4% of nonusers). In adjusted analysis, significantly better survival was observed for patients treated with ACEI/ARB (3-year hazard ratio: 0.80; 95% confidence interval: 0.77 to 0.83). The survival benefit was consistent through all kidney function strata, including dialysis patients. Overall, those treated with ACEI/ARB also had lower 3-year risk for myocardial infarction (hazard ratio: 0.91; 95% confidence interval: 0.87 to 0.95), whereas treatment had no significant effect on stroke risk. The crude risk for AKI was in general low (2.5% and 2.0% for treated and nontreated, respectively) and similar across estimated glomerular filtration rate categories but was significantly higher with ACEI/ARB treatment. However, the composite outcome of AKI and mortality favored ACEI/ARB treatment.

CONCLUSIONS

Treatment with ACEI/ARB after AMI was associated with improved long-term survival, regardless of underlying renal function, and was accompanied by low rates of adverse renal events.

Authors+Show Affiliations

Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden. Electronic address: marie.evans@ki.se.Renal Medicine, CLINTEC, Karolinska Institutet, Stockholm, Sweden; Institute for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.Department of Medicine, Huddinge, Section of Cardiology, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala, Sweden.Department of Medicine, Huddinge, Section of Cardiology, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.Uppsala Clinical Research Center, Uppsala, Sweden.Department of Medicine, Huddinge, Section of Cardiology, Karolinska Institutet, and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27056774

Citation

Evans, Marie, et al. "Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction." Journal of the American College of Cardiology, vol. 67, no. 14, 2016, pp. 1687-97.
Evans M, Carrero JJ, Szummer K, et al. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction. J Am Coll Cardiol. 2016;67(14):1687-97.
Evans, M., Carrero, J. J., Szummer, K., Åkerblom, A., Edfors, R., Spaak, J., Jacobson, S. H., Andell, P., Lindhagen, L., & Jernberg, T. (2016). Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction. Journal of the American College of Cardiology, 67(14), 1687-97. https://doi.org/10.1016/j.jacc.2016.01.050
Evans M, et al. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction. J Am Coll Cardiol. 2016 Apr 12;67(14):1687-97. PubMed PMID: 27056774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction. AU - Evans,Marie, AU - Carrero,Juan-Jesus, AU - Szummer,Karolina, AU - Åkerblom,Axel, AU - Edfors,Robert, AU - Spaak,Jonas, AU - Jacobson,Stefan H, AU - Andell,Pontus, AU - Lindhagen,Lars, AU - Jernberg,Tomas, PY - 2015/09/13/received PY - 2016/01/08/revised PY - 2016/01/28/accepted PY - 2016/4/9/entrez PY - 2016/4/9/pubmed PY - 2016/8/16/medline KW - chronic kidney disease KW - mortality KW - risk profile KW - survival analysis SP - 1687 EP - 97 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 67 IS - 14 N2 - BACKGROUND: There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI). OBJECTIVES: This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, including the entire spectrum of estimated glomerular filtration rates. METHODS: This study evaluated discharge and continuous follow-up data on ACEI/ARB use among AMI survivors (2006 to 2009) included in a large Swedish registry. The association between ACEI/ARB treatment and outcomes (mortality, myocardial infarction, stroke, and acute kidney injury [AKI]) was studied using Cox proportional hazards models (intention-to-treat and as treated). RESULTS: In total, 45,697 patients (71%) were treated with ACEI/ARB. The 3-year mortality was 19.8% (17.4% of ACEI/ARB users and 25.4% of nonusers). In adjusted analysis, significantly better survival was observed for patients treated with ACEI/ARB (3-year hazard ratio: 0.80; 95% confidence interval: 0.77 to 0.83). The survival benefit was consistent through all kidney function strata, including dialysis patients. Overall, those treated with ACEI/ARB also had lower 3-year risk for myocardial infarction (hazard ratio: 0.91; 95% confidence interval: 0.87 to 0.95), whereas treatment had no significant effect on stroke risk. The crude risk for AKI was in general low (2.5% and 2.0% for treated and nontreated, respectively) and similar across estimated glomerular filtration rate categories but was significantly higher with ACEI/ARB treatment. However, the composite outcome of AKI and mortality favored ACEI/ARB treatment. CONCLUSIONS: Treatment with ACEI/ARB after AMI was associated with improved long-term survival, regardless of underlying renal function, and was accompanied by low rates of adverse renal events. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/27056774/Angiotensin_Converting_Enzyme_Inhibitors_and_Angiotensin_Receptor_Blockers_in_Myocardial_Infarction_Patients_With_Renal_Dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(16)00510-6 DB - PRIME DP - Unbound Medicine ER -