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Influence of food and lifestyle on the risk of developing inflammatory bowel disease.
Intern Med J 2016; 46(6):669-76IM

Abstract

BACKGROUND

The Barwon area in Australia has one of the highest incidence rates of inflammatory bowel disease (IBD) and therefore is an ideal location to study the impact of environmental exposures on the disease's development.

AIM

To study these exposures prior to the development of IBD in a population-based cohort.

METHOD

One hundred and thirty-two incident cases (81 Crohn disease (CD) and 51 ulcerative colitis (UC)) from an IBD registry and 104 controls replied to the International Organization of Inflammatory Bowel Diseases environmental questionnaire. This included 87 questions about pre-illness exposures that included childhood illnesses, vaccinations, breastfeeding, house amenities, pets and swimming, diet and smoking.

RESULTS

The factors associated with CD included smoking (odds ratio (OR): 1.42, confidence interval (CI): 1-2.02, P = 0.029); childhood events, including tonsillectomy (OR: 1.74, CI: 1.15-2.6, P = 0.003) and chicken pox infection (OR: 3.89, CI: 1.61-9.4, P = 0.005) and pre-diagnosis intake of frequent fast food (OR: 2.26, CI: 1.76-4.33, P = 0.003). In UC, the risk factors included smoking (OR: 1.39, CI: 1.1-1.92, P = 0.026) and pre-diagnosis intake of frequent fast food (OR: 2.91, CI: 1.54-5.58, P < 0.001), and high caffeine intake was protective (OR: 0.51, 95% CI: 0.3-0.87, P = 0.002). Other protective exposures for UC included high fruit intake (OR: 0.59, CI: 0.4-0.88, P = 0.003) and having pets as a child (OR: 0.36, CI: 0.2-0.79, P = 0.001).

CONCLUSION

This first Australian population-based study of environmental risk factors confirms that smoking, childhood immunological events and dietary factors play a role in IBD development; while high caffeine intake and pet ownership offer a protective effect.

Authors+Show Affiliations

Department of Gastroenterology, The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.Gastroenterology Department, Royal Hobart Hospital, Hobart, Tasmania, Australia.Gastroenterology Department, North West Regional Hospital, Burnie, Tasmania, Australia.Department of Gastroenterology, The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Gastroenterology Department, Barwon Health, Geelong, Victoria, Australia.Department of Gastroenterology, The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.Department of Gastroenterology, The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.Department of Gastroenterology, The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27059169

Citation

Niewiadomski, O, et al. "Influence of Food and Lifestyle On the Risk of Developing Inflammatory Bowel Disease." Internal Medicine Journal, vol. 46, no. 6, 2016, pp. 669-76.
Niewiadomski O, Studd C, Wilson J, et al. Influence of food and lifestyle on the risk of developing inflammatory bowel disease. Intern Med J. 2016;46(6):669-76.
Niewiadomski, O., Studd, C., Wilson, J., Williams, J., Hair, C., Knight, R., ... Bell, S. (2016). Influence of food and lifestyle on the risk of developing inflammatory bowel disease. Internal Medicine Journal, 46(6), pp. 669-76. doi:10.1111/imj.13094.
Niewiadomski O, et al. Influence of Food and Lifestyle On the Risk of Developing Inflammatory Bowel Disease. Intern Med J. 2016;46(6):669-76. PubMed PMID: 27059169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of food and lifestyle on the risk of developing inflammatory bowel disease. AU - Niewiadomski,O, AU - Studd,C, AU - Wilson,J, AU - Williams,J, AU - Hair,C, AU - Knight,R, AU - Prewett,E, AU - Dabkowski,P, AU - Alexander,S, AU - Allen,B, AU - Dowling,D, AU - Connell,W, AU - Desmond,P, AU - Bell,S, PY - 2015/12/14/received PY - 2016/03/23/revised PY - 2016/03/23/accepted PY - 2016/4/10/entrez PY - 2016/4/10/pubmed PY - 2017/8/25/medline KW - Crohn disease KW - aetiology KW - environmental factors KW - epidemiology KW - inflammatory bowel disease KW - ulcerative colitis SP - 669 EP - 76 JF - Internal medicine journal JO - Intern Med J VL - 46 IS - 6 N2 - BACKGROUND: The Barwon area in Australia has one of the highest incidence rates of inflammatory bowel disease (IBD) and therefore is an ideal location to study the impact of environmental exposures on the disease's development. AIM: To study these exposures prior to the development of IBD in a population-based cohort. METHOD: One hundred and thirty-two incident cases (81 Crohn disease (CD) and 51 ulcerative colitis (UC)) from an IBD registry and 104 controls replied to the International Organization of Inflammatory Bowel Diseases environmental questionnaire. This included 87 questions about pre-illness exposures that included childhood illnesses, vaccinations, breastfeeding, house amenities, pets and swimming, diet and smoking. RESULTS: The factors associated with CD included smoking (odds ratio (OR): 1.42, confidence interval (CI): 1-2.02, P = 0.029); childhood events, including tonsillectomy (OR: 1.74, CI: 1.15-2.6, P = 0.003) and chicken pox infection (OR: 3.89, CI: 1.61-9.4, P = 0.005) and pre-diagnosis intake of frequent fast food (OR: 2.26, CI: 1.76-4.33, P = 0.003). In UC, the risk factors included smoking (OR: 1.39, CI: 1.1-1.92, P = 0.026) and pre-diagnosis intake of frequent fast food (OR: 2.91, CI: 1.54-5.58, P < 0.001), and high caffeine intake was protective (OR: 0.51, 95% CI: 0.3-0.87, P = 0.002). Other protective exposures for UC included high fruit intake (OR: 0.59, CI: 0.4-0.88, P = 0.003) and having pets as a child (OR: 0.36, CI: 0.2-0.79, P = 0.001). CONCLUSION: This first Australian population-based study of environmental risk factors confirms that smoking, childhood immunological events and dietary factors play a role in IBD development; while high caffeine intake and pet ownership offer a protective effect. SN - 1445-5994 UR - https://www.unboundmedicine.com/medline/citation/27059169/Influence_of_food_and_lifestyle_on_the_risk_of_developing_inflammatory_bowel_disease_ L2 - https://doi.org/10.1111/imj.13094 DB - PRIME DP - Unbound Medicine ER -