Tags

Type your tag names separated by a space and hit enter

Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana.
Clin Infect Dis. 2016 May 01; 62 Suppl 2:S168-74.CI

Abstract

BACKGROUND

A monovalent human rotavirus vaccine (RV1) was introduced in Botswana in July 2012. We assessed the impact of RV1 vaccination on childhood gastroenteritis-related hospitalizations and deaths in 2013 and 2014.

METHODS

We obtained data from registers of 4 hospitals in Botswana on hospitalizations and deaths from gastroenteritis, regardless of cause, among children <5 years of age. Gastroenteritis hospitalizations and deaths during the prevaccine period (January 2009-December 2012) were compared to the postvaccine period (January 2013-December 2014). Vaccine coverage was estimated from data collected through a concurrent vaccine effectiveness study at the same hospitals.

RESULTS

By December 2014, coverage with ≥1 dose of RV1 was an estimated 90% among infants <1 year of age and 76% among children 12-23 months of age. In the prevaccine period, the annual median number of gastroenteritis-related hospitalizations in children <5 years of age was 1212, and of gastroenteritis-related deaths in children <2 years of age was 77. In the postvaccine period, gastroenteritis-related hospitalizations decreased by 23% (95% confidence interval [CI], 16%-29%) to 937, and gastroenteritis-related deaths decreased by 22% (95% CI, -9% to 44%) to 60. Declines were most prominent during the rotavirus season (May-October) and among infants <1 year of age, with reductions of 43% (95% CI, 34%-51%) in gastroenteritis hospitalizations and 48% (95% CI, 11%-69%) in gastroenteritis deaths.

CONCLUSIONS

Following introduction of RV1 into the national immunization program, significant declines in hospitalizations and deaths from gastroenteritis were observed among children in Botswana, suggestive of the beneficial public health impact of rotavirus vaccination.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Pennsylvania Botswana-UPenn Partnership, Gaborone, Botswana.Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.Botswana-UPenn Partnership, Gaborone, Botswana Division of Microbiology, Department of Pathology, University of British Columbia, Vancouver, Canada Department of Pediatrics, University of Botswana, Gaborone Division of Infectious Disease, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.Botswana-UPenn Partnership, Gaborone, Botswana Division of Infectious Disease, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.National Health Laboratory, Gaborone, Botswana.Botswana-UPenn Partnership, Gaborone, Botswana.Botswana-UPenn Partnership, Gaborone, Botswana.Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.Botswana-UPenn Partnership, Gaborone, Botswana Department of Pediatrics, University of Botswana, Gaborone Division of Infectious Diseases and Section of Global Health, Department of Pediatrics, Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

27059352

Citation

Enane, Leslie A., et al. "Impact of Rotavirus Vaccination On Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 62 Suppl 2, 2016, pp. S168-74.
Enane LA, Gastañaduy PA, Goldfarb DM, et al. Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clin Infect Dis. 2016;62 Suppl 2:S168-74.
Enane, L. A., Gastañaduy, P. A., Goldfarb, D. M., Pernica, J. M., Mokomane, M., Moorad, B., Masole, L., Tate, J. E., Parashar, U. D., & Steenhoff, A. P. (2016). Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 62 Suppl 2, S168-74. https://doi.org/10.1093/cid/civ1210
Enane LA, et al. Impact of Rotavirus Vaccination On Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clin Infect Dis. 2016 May 1;62 Suppl 2:S168-74. PubMed PMID: 27059352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. AU - Enane,Leslie A, AU - Gastañaduy,Paul A, AU - Goldfarb,David M, AU - Pernica,Jeffrey M, AU - Mokomane,Margaret, AU - Moorad,Banno, AU - Masole,Lingani, AU - Tate,Jacqueline E, AU - Parashar,Umesh D, AU - Steenhoff,Andrew P, PY - 2016/4/10/entrez PY - 2016/4/10/pubmed PY - 2016/12/29/medline KW - morbidity KW - mortality KW - rotavirus vaccine SP - S168 EP - 74 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 62 Suppl 2 N2 - BACKGROUND: A monovalent human rotavirus vaccine (RV1) was introduced in Botswana in July 2012. We assessed the impact of RV1 vaccination on childhood gastroenteritis-related hospitalizations and deaths in 2013 and 2014. METHODS: We obtained data from registers of 4 hospitals in Botswana on hospitalizations and deaths from gastroenteritis, regardless of cause, among children <5 years of age. Gastroenteritis hospitalizations and deaths during the prevaccine period (January 2009-December 2012) were compared to the postvaccine period (January 2013-December 2014). Vaccine coverage was estimated from data collected through a concurrent vaccine effectiveness study at the same hospitals. RESULTS: By December 2014, coverage with ≥1 dose of RV1 was an estimated 90% among infants <1 year of age and 76% among children 12-23 months of age. In the prevaccine period, the annual median number of gastroenteritis-related hospitalizations in children <5 years of age was 1212, and of gastroenteritis-related deaths in children <2 years of age was 77. In the postvaccine period, gastroenteritis-related hospitalizations decreased by 23% (95% confidence interval [CI], 16%-29%) to 937, and gastroenteritis-related deaths decreased by 22% (95% CI, -9% to 44%) to 60. Declines were most prominent during the rotavirus season (May-October) and among infants <1 year of age, with reductions of 43% (95% CI, 34%-51%) in gastroenteritis hospitalizations and 48% (95% CI, 11%-69%) in gastroenteritis deaths. CONCLUSIONS: Following introduction of RV1 into the national immunization program, significant declines in hospitalizations and deaths from gastroenteritis were observed among children in Botswana, suggestive of the beneficial public health impact of rotavirus vaccination. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/27059352/Impact_of_Rotavirus_Vaccination_on_Hospitalizations_and_Deaths_From_Childhood_Gastroenteritis_in_Botswana_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/civ1210 DB - PRIME DP - Unbound Medicine ER -