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Ginsenoside Rb1 as a neuroprotective agent: A review.
Brain Res Bull. 2016 Jul; 125:30-43.BR

Abstract

Ginsenosides represent the major bioactive components of ginseng. These triterpenoid saponins have been shown to exert numerous beneficial effects on the human body. Recent evidences suggest that ginsenosides may be useful for the management and treatment of several diseases of the central nervous system (CNS). In particular, numerous in vitro and in vivo models have shown that ginsenosides can modulate numerous pharmacological effects on the brain, including attenuation of excitotoxicity, oxidative stress and neuroinflammation, maintenance of neurotransmitter balance, anti-apoptotic effects, and mitochondrial stabilization effects. Regulations of these pathophysiological mechanisms have been shown to improve cognitive function and protect the brain against several neurodegenerative diseases. This review will critically address the pharmacological effects and mechanisms of action of ginsenosides in the CNS, and particularly those associated with therapeutic efficacies in Parkinson's disease, Alzheimer's disease, Huntington's disease, and traumatic brain injury, and ischemia.

Authors+Show Affiliations

Neurobiology Laboratory, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.Neurobiology Laboratory, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.Neurobiology Laboratory, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan.Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Australia.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.Department of Chemistry, ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, CEP 78060-900, Cuiabá, MT, Brazil.Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

27060612

Citation

Ahmed, Touqeer, et al. "Ginsenoside Rb1 as a Neuroprotective Agent: a Review." Brain Research Bulletin, vol. 125, 2016, pp. 30-43.
Ahmed T, Raza SH, Maryam A, et al. Ginsenoside Rb1 as a neuroprotective agent: A review. Brain Res Bull. 2016;125:30-43.
Ahmed, T., Raza, S. H., Maryam, A., Setzer, W. N., Braidy, N., Nabavi, S. F., de Oliveira, M. R., & Nabavi, S. M. (2016). Ginsenoside Rb1 as a neuroprotective agent: A review. Brain Research Bulletin, 125, 30-43. https://doi.org/10.1016/j.brainresbull.2016.04.002
Ahmed T, et al. Ginsenoside Rb1 as a Neuroprotective Agent: a Review. Brain Res Bull. 2016;125:30-43. PubMed PMID: 27060612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ginsenoside Rb1 as a neuroprotective agent: A review. AU - Ahmed,Touqeer, AU - Raza,Syed Hammad, AU - Maryam,Afifa, AU - Setzer,William N, AU - Braidy,Nady, AU - Nabavi,Seyed Fazel, AU - de Oliveira,Marcos Roberto, AU - Nabavi,Seyed Mohammad, Y1 - 2016/04/06/ PY - 2015/12/12/received PY - 2016/3/21/revised PY - 2016/4/5/accepted PY - 2016/4/10/entrez PY - 2016/4/10/pubmed PY - 2017/10/31/medline KW - Alzheimer’s disease KW - Ginseng KW - Ginsenosides KW - Neurodegeneration KW - Parkinson’s disease SP - 30 EP - 43 JF - Brain research bulletin JO - Brain Res Bull VL - 125 N2 - Ginsenosides represent the major bioactive components of ginseng. These triterpenoid saponins have been shown to exert numerous beneficial effects on the human body. Recent evidences suggest that ginsenosides may be useful for the management and treatment of several diseases of the central nervous system (CNS). In particular, numerous in vitro and in vivo models have shown that ginsenosides can modulate numerous pharmacological effects on the brain, including attenuation of excitotoxicity, oxidative stress and neuroinflammation, maintenance of neurotransmitter balance, anti-apoptotic effects, and mitochondrial stabilization effects. Regulations of these pathophysiological mechanisms have been shown to improve cognitive function and protect the brain against several neurodegenerative diseases. This review will critically address the pharmacological effects and mechanisms of action of ginsenosides in the CNS, and particularly those associated with therapeutic efficacies in Parkinson's disease, Alzheimer's disease, Huntington's disease, and traumatic brain injury, and ischemia. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/27060612/Ginsenoside_Rb1_as_a_neuroprotective_agent:_A_review_ DB - PRIME DP - Unbound Medicine ER -