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Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study.
J Thromb Haemost 2016; 14(6):1183-91JT

Abstract

Essentials Registry-based studies indicate a link between arterial- and venous thromboembolism (VTE). We studied this association in a cohort with confounder information and validated outcomes. Myocardial infarction (MI) was associated with a 4.8-fold increased short-term risk of VTE. MI was associated with a transient increased risk of VTE, and pulmonary embolism in particular.

SUMMARY

Background Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives To study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. Methods Study participants (n = 29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-1995, 2001-2002, and 2007-2008) and followed up to 2010. All incident MI and VTE events during follow-up were recorded. Cox regression models with age as the time scale and MI as a time-dependent variable were used to calculate hazard ratios (HRs) of VTE adjusted for sex, body mass index, blood pressure, diabetes mellitus, HDL cholesterol, smoking, physical activity, and education level. Results During a median follow-up of 15.7 years, 1853 participants experienced an MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% confidence interval [CI] 1.08-2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07-2.75), but not significantly associated with the risk of deep vein thrombosis (DVT) (HR 1.36; 95% CI 0.86-2.15). The highest risk estimates for PE were observed during the first 6 months after the MI (HR 8.49; 95% CI 4.00-18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI patients (attributable risk). Conclusions Our findings indicate that MI is associated with a transient increased VTE risk, independently of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE.

Authors+Show Affiliations

K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Brain and Circulation Research Group, Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.K. G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø-The Arctic University of Norway, Tromsø, Norway. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27061154

Citation

Rinde, L B., et al. "Impact of Incident Myocardial Infarction On the Risk of Venous Thromboembolism: the Tromsø Study." Journal of Thrombosis and Haemostasis : JTH, vol. 14, no. 6, 2016, pp. 1183-91.
Rinde LB, Lind C, Småbrekke B, et al. Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. J Thromb Haemost. 2016;14(6):1183-91.
Rinde, L. B., Lind, C., Småbrekke, B., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., ... Hansen, J. B. (2016). Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. Journal of Thrombosis and Haemostasis : JTH, 14(6), pp. 1183-91. doi:10.1111/jth.13329.
Rinde LB, et al. Impact of Incident Myocardial Infarction On the Risk of Venous Thromboembolism: the Tromsø Study. J Thromb Haemost. 2016;14(6):1183-91. PubMed PMID: 27061154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of incident myocardial infarction on the risk of venous thromboembolism: the Tromsø Study. AU - Rinde,L B, AU - Lind,C, AU - Småbrekke,B, AU - Njølstad,I, AU - Mathiesen,E B, AU - Wilsgaard,T, AU - Løchen,M-L, AU - Hald,E M, AU - Vik,A, AU - Braekkan,S K, AU - Hansen,J-B, Y1 - 2016/05/10/ PY - 2016/02/09/received PY - 2016/04/02/accepted PY - 2016/4/11/entrez PY - 2016/4/12/pubmed PY - 2018/1/9/medline KW - epidemiology KW - myocardial infarction KW - pulmonary embolism KW - risk factors KW - venous thromboembolism SP - 1183 EP - 91 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 14 IS - 6 N2 - UNLABELLED: Essentials Registry-based studies indicate a link between arterial- and venous thromboembolism (VTE). We studied this association in a cohort with confounder information and validated outcomes. Myocardial infarction (MI) was associated with a 4.8-fold increased short-term risk of VTE. MI was associated with a transient increased risk of VTE, and pulmonary embolism in particular. SUMMARY: Background Recent studies have demonstrated an association between venous thromboembolism (VTE) and arterial thrombotic diseases. Objectives To study the association between incident myocardial infarction (MI) and VTE in a prospective population-based cohort. Methods Study participants (n = 29 506) were recruited from three surveys of the Tromsø Study (conducted in 1994-1995, 2001-2002, and 2007-2008) and followed up to 2010. All incident MI and VTE events during follow-up were recorded. Cox regression models with age as the time scale and MI as a time-dependent variable were used to calculate hazard ratios (HRs) of VTE adjusted for sex, body mass index, blood pressure, diabetes mellitus, HDL cholesterol, smoking, physical activity, and education level. Results During a median follow-up of 15.7 years, 1853 participants experienced an MI and 699 experienced a VTE. MI was associated with a 51% increased risk of VTE (HR 1.51; 95% confidence interval [CI] 1.08-2.10) and a 72% increased risk of pulmonary embolism (PE) (HR 1.72; 95% CI 1.07-2.75), but not significantly associated with the risk of deep vein thrombosis (DVT) (HR 1.36; 95% CI 0.86-2.15). The highest risk estimates for PE were observed during the first 6 months after the MI (HR 8.49; 95% CI 4.00-18.77). MI explained 6.2% of the PEs in the population (population attributable risk) and 78.5% of the PE risk in MI patients (attributable risk). Conclusions Our findings indicate that MI is associated with a transient increased VTE risk, independently of traditional atherosclerotic risk factors. The risk estimates were particularly high for PE. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/27061154/Impact_of_incident_myocardial_infarction_on_the_risk_of_venous_thromboembolism:_the_Tromsø_Study_ L2 - https://doi.org/10.1111/jth.13329 DB - PRIME DP - Unbound Medicine ER -