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Urinary neurotrophic peptides in postmenopausal women with and without overactive bladder.
Neurourol Urodyn. 2017 03; 36(3):740-744.NU

Abstract

AIMS

The aim of this study was to compare the expression of urinary nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), substance P (SP), and calcitonin-gene related peptide (CGRP) in women with and without overactive bladder (OAB). We sought to determine factors associated with higher expression of these neuropeptides.

METHODS

Participants with OAB and age-matched controls were enrolled. Symptom severity was assessed with validated questionnaires. Urinary neurotrophin levels, symptom scores, and clinical data were compared between the groups. Multivariate analysis determined independent factors associated with urinary neurotrophin levels.

RESULTS

Sixty-seven women (38 OAB, 29 controls) were included. Women with OAB and controls were similar in age, race, body mass index, parity, and smoking status. Women with OAB were more likely to report a history of pelvic pain and pelvic surgery. Neurotrophic factor levels normalized to urinary creatinine did not differ between the groups. Increasing age was associated with greater urinary levels of BDNF and NGF (β = 0.23, 95%CI 0.11-0.34 and 0.75, 95%CI 0.17-1.33, respectively, P < 0.02). Higher urinary NGF was associated with increasing BMI (β = 0.81, 95%CI 0.05-1.57, P = 0.04) while pain was associated with elevated urinary SP (β = 0.21, 95%CI 0.09-0.33, P = 0.001).

CONCLUSIONS

Our data does not support a relationship between urinary neurotrophin levels and OAB in age-matched postmenopausal women. Further research is necessary to elucidate the role of urinary neurotrophins in the diagnosis and management of OAB. Neurourol. Urodynam. 36:740-744, 2017. © 2016 Wiley Periodicals, Inc.

Authors+Show Affiliations

Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.Division of Urology, Department of Surgery, University of Colorado Denver School of Medicine, Denver, Colombia.Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27062604

Citation

Pennycuff, Jon F., et al. "Urinary Neurotrophic Peptides in Postmenopausal Women With and Without Overactive Bladder." Neurourology and Urodynamics, vol. 36, no. 3, 2017, pp. 740-744.
Pennycuff JF, Schutte SC, Hudson CO, et al. Urinary neurotrophic peptides in postmenopausal women with and without overactive bladder. Neurourol Urodyn. 2017;36(3):740-744.
Pennycuff, J. F., Schutte, S. C., Hudson, C. O., Karp, D. R., Malykhina, A. P., & Northington, G. M. (2017). Urinary neurotrophic peptides in postmenopausal women with and without overactive bladder. Neurourology and Urodynamics, 36(3), 740-744. https://doi.org/10.1002/nau.23011
Pennycuff JF, et al. Urinary Neurotrophic Peptides in Postmenopausal Women With and Without Overactive Bladder. Neurourol Urodyn. 2017;36(3):740-744. PubMed PMID: 27062604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary neurotrophic peptides in postmenopausal women with and without overactive bladder. AU - Pennycuff,Jon F, AU - Schutte,Stacey C, AU - Hudson,Catherine O, AU - Karp,Deborah R, AU - Malykhina,Anna P, AU - Northington,Gina M, Y1 - 2016/04/06/ PY - 2016/01/29/received PY - 2016/03/15/accepted PY - 2016/4/12/pubmed PY - 2018/1/13/medline PY - 2016/4/11/entrez KW - nerve growth factors KW - neuropeptides KW - overactive KW - substance P KW - urinary bladder SP - 740 EP - 744 JF - Neurourology and urodynamics JO - Neurourol Urodyn VL - 36 IS - 3 N2 - AIMS: The aim of this study was to compare the expression of urinary nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), substance P (SP), and calcitonin-gene related peptide (CGRP) in women with and without overactive bladder (OAB). We sought to determine factors associated with higher expression of these neuropeptides. METHODS: Participants with OAB and age-matched controls were enrolled. Symptom severity was assessed with validated questionnaires. Urinary neurotrophin levels, symptom scores, and clinical data were compared between the groups. Multivariate analysis determined independent factors associated with urinary neurotrophin levels. RESULTS: Sixty-seven women (38 OAB, 29 controls) were included. Women with OAB and controls were similar in age, race, body mass index, parity, and smoking status. Women with OAB were more likely to report a history of pelvic pain and pelvic surgery. Neurotrophic factor levels normalized to urinary creatinine did not differ between the groups. Increasing age was associated with greater urinary levels of BDNF and NGF (β = 0.23, 95%CI 0.11-0.34 and 0.75, 95%CI 0.17-1.33, respectively, P < 0.02). Higher urinary NGF was associated with increasing BMI (β = 0.81, 95%CI 0.05-1.57, P = 0.04) while pain was associated with elevated urinary SP (β = 0.21, 95%CI 0.09-0.33, P = 0.001). CONCLUSIONS: Our data does not support a relationship between urinary neurotrophin levels and OAB in age-matched postmenopausal women. Further research is necessary to elucidate the role of urinary neurotrophins in the diagnosis and management of OAB. Neurourol. Urodynam. 36:740-744, 2017. © 2016 Wiley Periodicals, Inc. SN - 1520-6777 UR - https://www.unboundmedicine.com/medline/citation/27062604/Urinary_neurotrophic_peptides_in_postmenopausal_women_with_and_without_overactive_bladder_ L2 - https://doi.org/10.1002/nau.23011 DB - PRIME DP - Unbound Medicine ER -