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An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation.
J Diet Suppl. 2016 Nov; 13(6):647-59.JD

Abstract

This study explored effects of ubiquinol-10 and ubiquinone-10, two different forms of coenzyme Q10, in diabetic rats. Oxidative stress is characterized by the depletion of antioxidant defenses and overproduction of free radicals that might contribute to, and even accelerate, the development of diabetes mellitus (DM) complications. Coenzyme Q10 was administered orally to diabetic rats and oxidative stress markers were then assessed. Bioavailability in normal rats was additionally assessed in various tissues and subcellular fractions after short-term and long-term coenzyme Q10 supplementation. Elevated nonfasting blood glucose and blood pressure in diabetic rats were decreased by ubiquinone-10. Both ubiquinol-10 and ubiquinone-10 ameliorated oxidative stress, based on assays for reactive oxygen metabolites and malondialdehyde. Coenzyme Q10 levels increased with both treatments and liver nicotinamide adenine dinucleotide phosphate (NADPH) coenzyme Q reductase with ubiquinone-10. Ubiquinol-10 was better absorbed in the liver and pancreas than ubiquinone-10, though both were similarly effective. In bioavailability study, a longer period of coenzyme Q10 supplementation did not lead to its accumulation in tissues or organelles. Both forms of coenzyme Q10 reduced oxidative stress in diabetic rats. Long-term supplementation of coenzyme Q10 appeared to be safe.

Authors+Show Affiliations

a Faculty of Tropical Medicine, Department of Tropical Nutrition and Food Science, Mahidol University , Bangkok , Thailand.b Division of Food Chemistry, Institute of Nutrition, Mahidol University , Nakhon Pathom , Thailand.c Department of Public Health, Sirindhorn College of Public Health Chonburi , Chonburi , Thailand.d Laboratory of Biochemistry, Division of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University , Kobe , Japan.d Laboratory of Biochemistry, Division of Health Sciences and Social Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University , Kobe , Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27064932

Citation

Prangthip, Pattaneeya, et al. "An Improvement of Oxidative Stress in Diabetic Rats By Ubiquinone-10 and Ubiquinol-10 and Bioavailability After Short- and Long-Term Coenzyme Q10 Supplementation." Journal of Dietary Supplements, vol. 13, no. 6, 2016, pp. 647-59.
Prangthip P, Kettawan A, Posuwan J, et al. An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation. J Diet Suppl. 2016;13(6):647-59.
Prangthip, P., Kettawan, A., Posuwan, J., Okuno, M., & Okamoto, T. (2016). An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation. Journal of Dietary Supplements, 13(6), 647-59. https://doi.org/10.3109/19390211.2016.1164788
Prangthip P, et al. An Improvement of Oxidative Stress in Diabetic Rats By Ubiquinone-10 and Ubiquinol-10 and Bioavailability After Short- and Long-Term Coenzyme Q10 Supplementation. J Diet Suppl. 2016;13(6):647-59. PubMed PMID: 27064932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation. AU - Prangthip,Pattaneeya, AU - Kettawan,Aikkarach, AU - Posuwan,Juthathip, AU - Okuno,Masaaki, AU - Okamoto,Tadashi, Y1 - 2016/04/11/ PY - 2016/4/12/entrez PY - 2016/4/12/pubmed PY - 2017/3/1/medline KW - bioavailability KW - coenzyme Q10 KW - diabetic rats KW - oxidative stress KW - ubiquinol-10 KW - ubiquinone-10 SP - 647 EP - 59 JF - Journal of dietary supplements JO - J Diet Suppl VL - 13 IS - 6 N2 - This study explored effects of ubiquinol-10 and ubiquinone-10, two different forms of coenzyme Q10, in diabetic rats. Oxidative stress is characterized by the depletion of antioxidant defenses and overproduction of free radicals that might contribute to, and even accelerate, the development of diabetes mellitus (DM) complications. Coenzyme Q10 was administered orally to diabetic rats and oxidative stress markers were then assessed. Bioavailability in normal rats was additionally assessed in various tissues and subcellular fractions after short-term and long-term coenzyme Q10 supplementation. Elevated nonfasting blood glucose and blood pressure in diabetic rats were decreased by ubiquinone-10. Both ubiquinol-10 and ubiquinone-10 ameliorated oxidative stress, based on assays for reactive oxygen metabolites and malondialdehyde. Coenzyme Q10 levels increased with both treatments and liver nicotinamide adenine dinucleotide phosphate (NADPH) coenzyme Q reductase with ubiquinone-10. Ubiquinol-10 was better absorbed in the liver and pancreas than ubiquinone-10, though both were similarly effective. In bioavailability study, a longer period of coenzyme Q10 supplementation did not lead to its accumulation in tissues or organelles. Both forms of coenzyme Q10 reduced oxidative stress in diabetic rats. Long-term supplementation of coenzyme Q10 appeared to be safe. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/27064932/An_Improvement_of_Oxidative_Stress_in_Diabetic_Rats_by_Ubiquinone_10_and_Ubiquinol_10_and_Bioavailability_after_Short__and_Long_Term_Coenzyme_Q10_Supplementation_ L2 - http://www.tandfonline.com/doi/full/10.3109/19390211.2016.1164788 DB - PRIME DP - Unbound Medicine ER -