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Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis.
Atherosclerosis. 2016 06; 249:65-9.A

Abstract

BACKGROUND AND AIMS

Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are widely recognized to have beneficial effects against cardiovascular disease. We investigated the association of n-3 PUFAs levels with carotid atherosclerosis in patients on hemodialysis (HD), who are at high risk for cardiovascular events.

METHODS

Carotid ultra-sound was performed in a total of 461 patients on HD (male 67%, age 67 ± 12years, diabetes rate 46%). Intima-media thickness (IMT) and the plaque score (PS) in carotid arteries were measured. Carotid atherosclerosis was defined as IMT >1.2 mm and/or PS > 5.0. The levels of n-6 PUFAs [dihomo-gamma-linolenic acid (DHLA) and arachidonic acid (AA)] and n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] were also measured prior to carotid ultra-sound.

RESULTS

Carotid atherosclerosis was observed in 94 patients (20.4%). Individual PUFAs levels were comparable between patients with and without carotid atherosclerosis. However, the ratio of EPA/AA and that of n-3/n-6 PUFAs were significantly lower in patients with carotid atherosclerosis compared to those without (median 0.36 vs. 0.41, p = 0.031 and 0.85 vs. 0.93, p = 0.041, respectively]. After adjustment for other confounders, the ratio of EPA/AA (OR 0.30, 95% CI 0.12-0.70, p = 0.0055) and the ratio of n-3/n-6 PUFAs (OR 0.45, 95% CI 0.25-0.80, p = 0.0066) showed an independent reverse association with carotid atherosclerosis. In addition, the area under receiver-operating characteristic curves for carotid atherosclerosis was significantly greater in an established risk model with EPA/AA and n-3/n-6 ratios than in the established risk model alone.

CONCLUSIONS

These data suggest that low ratios of both EPA/AA ratio and n-3/n-6 PUFAs were closely associated with carotid atherosclerosis in patients on HD.

Authors+Show Affiliations

Cardiolovascular Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: hkishii@med.nagoya-u.ac.jp.Cardiolovascular Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.Cardiolovascular Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.Cardiolovascular Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.Division of Medical Statistics, Fujita Health University, Toyoake, Japan.Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Internal Medicine, School of Dentistry Aichi-Gakuin University, Nagoya, Japan.Cardiolovascular Center, Nagoya Kyoritsu Hospital, Nagoya, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27065243

Citation

Umemoto, Norio, et al. "Reverse Association of Omega-3/omega-6 Polyunsaturated Fatty Acids Ratios With Carotid Atherosclerosis in Patients On Hemodialysis." Atherosclerosis, vol. 249, 2016, pp. 65-9.
Umemoto N, Ishii H, Kamoi D, et al. Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis. Atherosclerosis. 2016;249:65-9.
Umemoto, N., Ishii, H., Kamoi, D., Aoyama, T., Sakakibara, T., Takahashi, H., Tanaka, A., Yasuda, Y., Suzuki, S., Matsubara, T., & Murohara, T. (2016). Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis. Atherosclerosis, 249, 65-9. https://doi.org/10.1016/j.atherosclerosis.2016.03.037
Umemoto N, et al. Reverse Association of Omega-3/omega-6 Polyunsaturated Fatty Acids Ratios With Carotid Atherosclerosis in Patients On Hemodialysis. Atherosclerosis. 2016;249:65-9. PubMed PMID: 27065243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reverse association of omega-3/omega-6 polyunsaturated fatty acids ratios with carotid atherosclerosis in patients on hemodialysis. AU - Umemoto,Norio, AU - Ishii,Hideki, AU - Kamoi,Daisuke, AU - Aoyama,Toru, AU - Sakakibara,Takashi, AU - Takahashi,Hiroshi, AU - Tanaka,Akihito, AU - Yasuda,Yoshinari, AU - Suzuki,Susumu, AU - Matsubara,Tatsuaki, AU - Murohara,Toyoaki, Y1 - 2016/04/01/ PY - 2015/12/12/received PY - 2016/03/24/revised PY - 2016/03/30/accepted PY - 2016/4/12/entrez PY - 2016/4/12/pubmed PY - 2017/11/29/medline KW - Atherosclerosis KW - Hemodialysis KW - Polyunsaturated fatty acids SP - 65 EP - 9 JF - Atherosclerosis JO - Atherosclerosis VL - 249 N2 - BACKGROUND AND AIMS: Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are widely recognized to have beneficial effects against cardiovascular disease. We investigated the association of n-3 PUFAs levels with carotid atherosclerosis in patients on hemodialysis (HD), who are at high risk for cardiovascular events. METHODS: Carotid ultra-sound was performed in a total of 461 patients on HD (male 67%, age 67 ± 12years, diabetes rate 46%). Intima-media thickness (IMT) and the plaque score (PS) in carotid arteries were measured. Carotid atherosclerosis was defined as IMT >1.2 mm and/or PS > 5.0. The levels of n-6 PUFAs [dihomo-gamma-linolenic acid (DHLA) and arachidonic acid (AA)] and n-3 PUFAs [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] were also measured prior to carotid ultra-sound. RESULTS: Carotid atherosclerosis was observed in 94 patients (20.4%). Individual PUFAs levels were comparable between patients with and without carotid atherosclerosis. However, the ratio of EPA/AA and that of n-3/n-6 PUFAs were significantly lower in patients with carotid atherosclerosis compared to those without (median 0.36 vs. 0.41, p = 0.031 and 0.85 vs. 0.93, p = 0.041, respectively]. After adjustment for other confounders, the ratio of EPA/AA (OR 0.30, 95% CI 0.12-0.70, p = 0.0055) and the ratio of n-3/n-6 PUFAs (OR 0.45, 95% CI 0.25-0.80, p = 0.0066) showed an independent reverse association with carotid atherosclerosis. In addition, the area under receiver-operating characteristic curves for carotid atherosclerosis was significantly greater in an established risk model with EPA/AA and n-3/n-6 ratios than in the established risk model alone. CONCLUSIONS: These data suggest that low ratios of both EPA/AA ratio and n-3/n-6 PUFAs were closely associated with carotid atherosclerosis in patients on HD. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/27065243/Reverse_association_of_omega_3/omega_6_polyunsaturated_fatty_acids_ratios_with_carotid_atherosclerosis_in_patients_on_hemodialysis_ DB - PRIME DP - Unbound Medicine ER -