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Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma.
Ultrasound Med Biol. 2016 07; 42(7):1457-63.UM

Abstract

The aim of the study described here was to determine underestimation rates and identify radiologic predictors of underestimation for columnar cell lesions (CCLs) and atypical ductal hyperplasia (ADH) detected by ultrasound-guided core needle biopsy. A total of 103 CCLs and ADH lesions in 100 patients diagnosed by ultrasound-guided core needle biopsy were evaluated. Breast sonographic and mammographic findings were reviewed, and underestimation rates were determined by surgical excision, percutaneous vacuum-assisted excision or 2-y imaging follow-up. All underestimated lesions were ductal carcinoma in situ, and the underestimation rates of flat epithelial atypia (FEA), FEA + ADH and ADH were 5.9% (1/17), 44.4% (4/9) and 27.3% (12/44), respectively. There was no underestimation of CCLs without atypia. The presence of calcifications on ultrasound was significantly associated with underestimation (p = 0.010). Therefore, except for CCLs without atypia, all other lesions may require excision, especially when calcification is present on ultrasound or when FEA + ADH is found.

Authors+Show Affiliations

Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea; Department of Radiology, Chung-Ang University Hospital, Seoul, Korea.Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea. Electronic address: mjjang74@gmail.com.Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.Department of Surgery, Breast Care Center, Daerim St. Mary's Hospital, Seoul, Korea.Department of Surgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.Department of Pathology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27067419

Citation

Ahn, Hye Shin, et al. "Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia By Ultrasound-Guided Core Biopsy: Findings Associated With Underestimation of Breast Carcinoma." Ultrasound in Medicine & Biology, vol. 42, no. 7, 2016, pp. 1457-63.
Ahn HS, Jang M, Kim SM, et al. Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound Med Biol. 2016;42(7):1457-63.
Ahn, H. S., Jang, M., Kim, S. M., Yun, B. L., Kim, S. W., Kang, E. Y., & Park, S. Y. (2016). Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. Ultrasound in Medicine & Biology, 42(7), 1457-63. https://doi.org/10.1016/j.ultrasmedbio.2016.02.009
Ahn HS, et al. Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia By Ultrasound-Guided Core Biopsy: Findings Associated With Underestimation of Breast Carcinoma. Ultrasound Med Biol. 2016;42(7):1457-63. PubMed PMID: 27067419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of Columnar Cell Lesions and Atypical Ductal Hyperplasia by Ultrasound-Guided Core Biopsy: Findings Associated with Underestimation of Breast Carcinoma. AU - Ahn,Hye Shin, AU - Jang,Mijung, AU - Kim,Sun Mi, AU - Yun,Bo La, AU - Kim,Sung-Won, AU - Kang,Eun Young, AU - Park,So Yeon, Y1 - 2016/04/08/ PY - 2015/08/11/received PY - 2016/02/09/revised PY - 2016/02/10/accepted PY - 2016/4/13/entrez PY - 2016/4/14/pubmed PY - 2017/11/10/medline KW - Atypical ductal hyperplasia KW - Breast ultrasound KW - Columnar cell lesion KW - Core needle biopsy KW - Underestimation SP - 1457 EP - 63 JF - Ultrasound in medicine & biology JO - Ultrasound Med Biol VL - 42 IS - 7 N2 - The aim of the study described here was to determine underestimation rates and identify radiologic predictors of underestimation for columnar cell lesions (CCLs) and atypical ductal hyperplasia (ADH) detected by ultrasound-guided core needle biopsy. A total of 103 CCLs and ADH lesions in 100 patients diagnosed by ultrasound-guided core needle biopsy were evaluated. Breast sonographic and mammographic findings were reviewed, and underestimation rates were determined by surgical excision, percutaneous vacuum-assisted excision or 2-y imaging follow-up. All underestimated lesions were ductal carcinoma in situ, and the underestimation rates of flat epithelial atypia (FEA), FEA + ADH and ADH were 5.9% (1/17), 44.4% (4/9) and 27.3% (12/44), respectively. There was no underestimation of CCLs without atypia. The presence of calcifications on ultrasound was significantly associated with underestimation (p = 0.010). Therefore, except for CCLs without atypia, all other lesions may require excision, especially when calcification is present on ultrasound or when FEA + ADH is found. SN - 1879-291X UR - https://www.unboundmedicine.com/medline/citation/27067419/Diagnosis_of_Columnar_Cell_Lesions_and_Atypical_Ductal_Hyperplasia_by_Ultrasound_Guided_Core_Biopsy:_Findings_Associated_with_Underestimation_of_Breast_Carcinoma_ DB - PRIME DP - Unbound Medicine ER -