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Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm.
Hum Pathol. 2016 May; 51:103-13.HP

Abstract

Intraductal papillary neoplasm of bile duct (IPNB) is a papillary tumor covered by well-differentiated neoplastic epithelium with fine fibrovascular cores in the dilated bile ducts. It reportedly shows similarities to intraductal papillary mucinous neoplasm of pancreas (IPMN), to various degrees. Herein, IPNB was pathologically analyzed by classifying 52 cases into 4 groups based on the histopathologic similarities to IPMN: group A (identical to IPMN, 19 cases), group B (similar to but slightly different from IPMN, 18 cases), group C (vaguely similar to IPMN, 5 cases), and group D (different from IPMN, 10 cases). In group A, intrahepatic and perihilar regions were mainly affected, most cases were of low/intermediate or high grade without invasion, and gastric type was the most common phenotype, followed by oncocytic and intestinal types. In groups C and D, perihilar and distal bile ducts were affected, almost all cases were of high grade with invasion, and most of them were of intestinal and pancreatobiliary phenotypes. Most group B cases were of intestinal phenotype, and all were of high grade with or without invasion. In conclusion, these 4 groups of IPNB showed unique pathologic features and behaviors. Group A cases were less aggressive and shared many features with IPMN, whereas group C and D cases were more aggressive and mainly found in perihilar and distal bile ducts. Group B resembling IPMN was intermediate between them. This classification may be useful in clinical practice and holds promise for a novel approach to analyze IPNB tumorigenesis.

Authors+Show Affiliations

Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan. Electronic address: nakanuma@staff.kanazawa-u.ac.jp.Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.Department of Hepatobiliary Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.Department of Hepatobiliary Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.Department of Hepatobiliary Surgery, Shizuoka Cancer Center, Shizuoka 411-8777, Japan.Department of Human Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan.Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan.Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan.Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan.Department of Clinical Laboratory, Koshigaya City Hospital, Koshigaya 343-8577, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27067788

Citation

Nakanuma, Yasuni, et al. "Characterization of Intraductal Papillary Neoplasm of Bile Duct With Respect to Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm." Human Pathology, vol. 51, 2016, pp. 103-13.
Nakanuma Y, Kakuda Y, Uesaka K, et al. Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. Hum Pathol. 2016;51:103-13.
Nakanuma, Y., Kakuda, Y., Uesaka, K., Miyata, T., Yamamoto, Y., Fukumura, Y., Sato, Y., Sasaki, M., Harada, K., & Takase, M. (2016). Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. Human Pathology, 51, 103-13. https://doi.org/10.1016/j.humpath.2015.12.022
Nakanuma Y, et al. Characterization of Intraductal Papillary Neoplasm of Bile Duct With Respect to Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm. Hum Pathol. 2016;51:103-13. PubMed PMID: 27067788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. AU - Nakanuma,Yasuni, AU - Kakuda,Yuko, AU - Uesaka,Katsuhiko, AU - Miyata,Takashi, AU - Yamamoto,Yusuke, AU - Fukumura,Yuki, AU - Sato,Yasunori, AU - Sasaki,Motoko, AU - Harada,Kenichi, AU - Takase,Masaru, Y1 - 2016/01/19/ PY - 2015/06/16/received PY - 2015/12/25/revised PY - 2015/12/30/accepted PY - 2016/4/13/entrez PY - 2016/4/14/pubmed PY - 2016/8/23/medline KW - Bile duct KW - Intraductal papillary neoplasm KW - Invasion KW - Pancreas KW - Phenotype SP - 103 EP - 13 JF - Human pathology JO - Hum. Pathol. VL - 51 N2 - Intraductal papillary neoplasm of bile duct (IPNB) is a papillary tumor covered by well-differentiated neoplastic epithelium with fine fibrovascular cores in the dilated bile ducts. It reportedly shows similarities to intraductal papillary mucinous neoplasm of pancreas (IPMN), to various degrees. Herein, IPNB was pathologically analyzed by classifying 52 cases into 4 groups based on the histopathologic similarities to IPMN: group A (identical to IPMN, 19 cases), group B (similar to but slightly different from IPMN, 18 cases), group C (vaguely similar to IPMN, 5 cases), and group D (different from IPMN, 10 cases). In group A, intrahepatic and perihilar regions were mainly affected, most cases were of low/intermediate or high grade without invasion, and gastric type was the most common phenotype, followed by oncocytic and intestinal types. In groups C and D, perihilar and distal bile ducts were affected, almost all cases were of high grade with invasion, and most of them were of intestinal and pancreatobiliary phenotypes. Most group B cases were of intestinal phenotype, and all were of high grade with or without invasion. In conclusion, these 4 groups of IPNB showed unique pathologic features and behaviors. Group A cases were less aggressive and shared many features with IPMN, whereas group C and D cases were more aggressive and mainly found in perihilar and distal bile ducts. Group B resembling IPMN was intermediate between them. This classification may be useful in clinical practice and holds promise for a novel approach to analyze IPNB tumorigenesis. SN - 1532-8392 UR - https://www.unboundmedicine.com/medline/citation/27067788/Characterization_of_intraductal_papillary_neoplasm_of_bile_duct_with_respect_to_histopathologic_similarities_to_pancreatic_intraductal_papillary_mucinous_neoplasm_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(16)00024-1 DB - PRIME DP - Unbound Medicine ER -