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[Use of Transdermal Fentanyl in a Hospital].
Gan To Kagaku Ryoho. 2016 Mar; 43(3):341-4.GT

Abstract

Recently, the use of transdermal fentanyl (TDF) has been increasing at our hospital owing to its convenience. Furthermore, TDF tends to be increasingly used for patients who have never used opioids. However, the appropriate criteria for indicating TDF have not been established yet. Therefore, we examined how TDF was prescribed in practice and determined its effective dosage. In 43 cases, the reasons, effects, and side effects of TDF were investigated retrospectively. Of the patients, 60% continued using TDF for 30 days. Meanwhile, approximately 25% of them terminated TDF therapy within 8 days. Of those who discontinued TDF therapy, some entirely stopped taking TDF and others chose other opioids instead because of poor pain control. Before receiving TDF therapy, 17 patients (45%) used oxycodone and 14 (37%) never used opioids. In addition, the main reason for starting TDF in opioid-naive patients was gastrointestinal condition. Between opioid-naive and opioid-using groups, no significant differences were observed in usage duration and incidence of side effects. The side effects included somnolence in 6 patients, delirium in 2 patients, and nausea and vomiting, constipation, and breathing restraint in 1 patient each. TDF was considered as an effective treatment regardless of the previous use of opioids. Nonetheless, careful deliberation is necessary because of the slow effects and difficulty with dosage adjustment.

Authors+Show Affiliations

Sako A
Dept. of Pharmacy, National Hospital Organization Kasumigaura Medical Center.
Yoshikawa Y
No affiliation info available
Kikuchi N
No affiliation info available
Watanabe A
No affiliation info available
Yoshida S
No affiliation info available

MeSH

Administration, CutaneousAdultAgedAged, 80 and overAnalgesics, OpioidFemaleFentanylHumansMaleMiddle AgedNeoplasmsPainRetrospective StudiesTreatment Outcome

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

27067851

Citation

Sako, Azumi, et al. "[Use of Transdermal Fentanyl in a Hospital]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 43, no. 3, 2016, pp. 341-4.
Sako A, Yoshikawa Y, Kikuchi N, et al. [Use of Transdermal Fentanyl in a Hospital]. Gan To Kagaku Ryoho. 2016;43(3):341-4.
Sako, A., Yoshikawa, Y., Kikuchi, N., Watanabe, A., & Yoshida, S. (2016). [Use of Transdermal Fentanyl in a Hospital]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 43(3), 341-4.
Sako A, et al. [Use of Transdermal Fentanyl in a Hospital]. Gan To Kagaku Ryoho. 2016;43(3):341-4. PubMed PMID: 27067851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of Transdermal Fentanyl in a Hospital]. AU - Sako,Azumi, AU - Yoshikawa,Yuka, AU - Kikuchi,Norihiro, AU - Watanabe,Atsuko, AU - Yoshida,Seiya, PY - 2016/4/13/entrez PY - 2016/4/14/pubmed PY - 2016/5/27/medline SP - 341 EP - 4 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 43 IS - 3 N2 - Recently, the use of transdermal fentanyl (TDF) has been increasing at our hospital owing to its convenience. Furthermore, TDF tends to be increasingly used for patients who have never used opioids. However, the appropriate criteria for indicating TDF have not been established yet. Therefore, we examined how TDF was prescribed in practice and determined its effective dosage. In 43 cases, the reasons, effects, and side effects of TDF were investigated retrospectively. Of the patients, 60% continued using TDF for 30 days. Meanwhile, approximately 25% of them terminated TDF therapy within 8 days. Of those who discontinued TDF therapy, some entirely stopped taking TDF and others chose other opioids instead because of poor pain control. Before receiving TDF therapy, 17 patients (45%) used oxycodone and 14 (37%) never used opioids. In addition, the main reason for starting TDF in opioid-naive patients was gastrointestinal condition. Between opioid-naive and opioid-using groups, no significant differences were observed in usage duration and incidence of side effects. The side effects included somnolence in 6 patients, delirium in 2 patients, and nausea and vomiting, constipation, and breathing restraint in 1 patient each. TDF was considered as an effective treatment regardless of the previous use of opioids. Nonetheless, careful deliberation is necessary because of the slow effects and difficulty with dosage adjustment. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/27067851/[Use_of_Transdermal_Fentanyl_in_a_Hospital]_ DB - PRIME DP - Unbound Medicine ER -