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Dietary mineral intake and lung cancer risk: the Rotterdam Study.
Eur J Nutr. 2017 Jun; 56(4):1637-1646.EJ

Abstract

OBJECTIVE

Limited data are available on the role of mineral intake in the development of lung cancer (LC). We investigated whether dietary calcium, copper, iron, magnesium, selenium and zinc intake were associated with LC risk.

METHODS

We analyzed data from 5435 participants of the Rotterdam Study, a prospective population-based cohort study among subjects aged 55 years and older. At baseline (1990-1993), diet was measured by a validated food frequency questionnaire. LC events were diagnosed on the basis of pathology data and medical records. Hazard ratios (HRs) on LC for energy-adjusted mineral intake were calculated using Cox regression models while adjusting for potential confounders.

RESULTS

During a follow-up period of 22 years, we identified 211 incident cases of LC. A higher zinc intake was associated with 42 % reduction in risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.35; 0.94, P-for trend = 0.039). Similarly, high intake of iron was associated with reduced risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.37; 0.92, P-for trend = 0.021). There was no association between dietary intake of calcium, copper, magnesium and selenium and LC risk.

CONCLUSIONS

Our results suggest that dietary zinc and iron intake are associated with reduced risk of LC. No evidence was found for an association between calcium, copper, magnesium and selenium intake and LC risk.

Authors+Show Affiliations

Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Department of Biomedical Sciences, Faculty of Medicine, University of Medicine, Tirana, Albania. University Clinic of Gastrohepatology, University Hospital Center Mother Teresa, Tirana, Albania.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Department of Internal Medicine, Groene Hart Hospital, Gouda, The Netherlands.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Health Care Inspectorate, The Hague, The Netherlands.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. b.stricker@erasmusmc.nl. Health Care Inspectorate, The Hague, The Netherlands. b.stricker@erasmusmc.nl.Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. Leiden University College, The Hague, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27073037

Citation

Muka, Taulant, et al. "Dietary Mineral Intake and Lung Cancer Risk: the Rotterdam Study." European Journal of Nutrition, vol. 56, no. 4, 2017, pp. 1637-1646.
Muka T, Kraja B, Ruiter R, et al. Dietary mineral intake and lung cancer risk: the Rotterdam Study. Eur J Nutr. 2017;56(4):1637-1646.
Muka, T., Kraja, B., Ruiter, R., Lahousse, L., de Keyser, C. E., Hofman, A., Franco, O. H., Brusselle, G., Stricker, B. H., & Kiefte-de Jong, J. C. (2017). Dietary mineral intake and lung cancer risk: the Rotterdam Study. European Journal of Nutrition, 56(4), 1637-1646. https://doi.org/10.1007/s00394-016-1210-4
Muka T, et al. Dietary Mineral Intake and Lung Cancer Risk: the Rotterdam Study. Eur J Nutr. 2017;56(4):1637-1646. PubMed PMID: 27073037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary mineral intake and lung cancer risk: the Rotterdam Study. AU - Muka,Taulant, AU - Kraja,Bledar, AU - Ruiter,Rikje, AU - Lahousse,Lies, AU - de Keyser,Catherine E, AU - Hofman,Albert, AU - Franco,Oscar H, AU - Brusselle,Guy, AU - Stricker,Bruno H, AU - Kiefte-de Jong,Jessica C, Y1 - 2016/04/12/ PY - 2015/12/23/received PY - 2016/03/23/accepted PY - 2016/4/14/pubmed PY - 2018/4/20/medline PY - 2016/4/14/entrez KW - Calcium KW - Copper KW - Iron KW - Lung cancer KW - Magnesium KW - Selenium KW - Zinc SP - 1637 EP - 1646 JF - European journal of nutrition JO - Eur J Nutr VL - 56 IS - 4 N2 - OBJECTIVE: Limited data are available on the role of mineral intake in the development of lung cancer (LC). We investigated whether dietary calcium, copper, iron, magnesium, selenium and zinc intake were associated with LC risk. METHODS: We analyzed data from 5435 participants of the Rotterdam Study, a prospective population-based cohort study among subjects aged 55 years and older. At baseline (1990-1993), diet was measured by a validated food frequency questionnaire. LC events were diagnosed on the basis of pathology data and medical records. Hazard ratios (HRs) on LC for energy-adjusted mineral intake were calculated using Cox regression models while adjusting for potential confounders. RESULTS: During a follow-up period of 22 years, we identified 211 incident cases of LC. A higher zinc intake was associated with 42 % reduction in risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.35; 0.94, P-for trend = 0.039). Similarly, high intake of iron was associated with reduced risk of LC (top tertile vs. first tertile: HR 0.58, 95 % CI 0.37; 0.92, P-for trend = 0.021). There was no association between dietary intake of calcium, copper, magnesium and selenium and LC risk. CONCLUSIONS: Our results suggest that dietary zinc and iron intake are associated with reduced risk of LC. No evidence was found for an association between calcium, copper, magnesium and selenium intake and LC risk. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/27073037/Dietary_mineral_intake_and_lung_cancer_risk:_the_Rotterdam_Study_ L2 - https://dx.doi.org/10.1007/s00394-016-1210-4 DB - PRIME DP - Unbound Medicine ER -