Tags

Type your tag names separated by a space and hit enter

A Case of Apoplexy Attack-Like Neuropathy due to Hereditary Neuropathy with Liability to Pressure Palsies in a Patient Diagnosed with Chronic Cerebral Infarction.
J Stroke Cerebrovasc Dis. 2016 Jun; 25(6):e83-5.JS

Abstract

Hereditary neuropathy with liability to pressure palsies is an inherited disease associated with the loss of a copy of the PMP22 gene. The condition leads to mononeuropathy due to compression and easy strangulation during daily life activities, resulting in sudden muscle weakness and sensory disturbance, and displaying symptoms similar to cerebrovascular diseases. We report the case of an 80-year-old man with left paralysis due to chronic cerebral infarction. His medical history indicated remarkable recovery from about 4 months after the onset of left hemiplegia with predominant involvement of the fingers. Despite subsequent recurrent monoplegia of the upper or lower limbs, brain magnetic resonance imaging consistently revealed only previous cerebral infarction in the right corona radiata without new lesions. Medical examination showed reduced deep tendon reflexes in his extremities on both the healthy and hemiplegic sides. Nerve conduction studies showed delayed conduction at the bilateral carpal and cubital tunnels and near the right caput fibulae. Genetic analysis revealed loss of a copy of the PMP22 gene. Thus, he was diagnosed with a cerebral infarction complicated by hereditary neuropathy with liability to pressure palsies. Stroke patients develop sudden muscle weakness and sensory disturbance. However, if such patients have no hyperactive deep tendon reflexes and show atypical recovery of paralysis that does not correspond to findings of imaging modalities, nerve conduction studies and genetic analysis may be necessary, considering the complication of hereditary neuropathy with liability to pressure palsies.

Authors+Show Affiliations

Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address: akih815@med.uoeh-u.ac.jp.Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.Moji Medical Center, Kitakyushu, Japan.Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

27080157

Citation

Hachisuka, Akiko, et al. "A Case of Apoplexy Attack-Like Neuropathy Due to Hereditary Neuropathy With Liability to Pressure Palsies in a Patient Diagnosed With Chronic Cerebral Infarction." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 25, no. 6, 2016, pp. e83-5.
Hachisuka A, Matsushima Y, Hachisuka K, et al. A Case of Apoplexy Attack-Like Neuropathy due to Hereditary Neuropathy with Liability to Pressure Palsies in a Patient Diagnosed with Chronic Cerebral Infarction. J Stroke Cerebrovasc Dis. 2016;25(6):e83-5.
Hachisuka, A., Matsushima, Y., Hachisuka, K., & Saeki, S. (2016). A Case of Apoplexy Attack-Like Neuropathy due to Hereditary Neuropathy with Liability to Pressure Palsies in a Patient Diagnosed with Chronic Cerebral Infarction. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 25(6), e83-5. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.03.031
Hachisuka A, et al. A Case of Apoplexy Attack-Like Neuropathy Due to Hereditary Neuropathy With Liability to Pressure Palsies in a Patient Diagnosed With Chronic Cerebral Infarction. J Stroke Cerebrovasc Dis. 2016;25(6):e83-5. PubMed PMID: 27080157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Case of Apoplexy Attack-Like Neuropathy due to Hereditary Neuropathy with Liability to Pressure Palsies in a Patient Diagnosed with Chronic Cerebral Infarction. AU - Hachisuka,Akiko, AU - Matsushima,Yasuyuki, AU - Hachisuka,Kenji, AU - Saeki,Satoru, Y1 - 2016/04/11/ PY - 2015/06/01/received PY - 2015/12/24/revised PY - 2016/03/17/accepted PY - 2016/4/16/entrez PY - 2016/4/16/pubmed PY - 2017/4/11/medline KW - HNPP KW - PMP22 gene KW - TIA KW - cerebral infarction SP - e83 EP - 5 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 25 IS - 6 N2 - Hereditary neuropathy with liability to pressure palsies is an inherited disease associated with the loss of a copy of the PMP22 gene. The condition leads to mononeuropathy due to compression and easy strangulation during daily life activities, resulting in sudden muscle weakness and sensory disturbance, and displaying symptoms similar to cerebrovascular diseases. We report the case of an 80-year-old man with left paralysis due to chronic cerebral infarction. His medical history indicated remarkable recovery from about 4 months after the onset of left hemiplegia with predominant involvement of the fingers. Despite subsequent recurrent monoplegia of the upper or lower limbs, brain magnetic resonance imaging consistently revealed only previous cerebral infarction in the right corona radiata without new lesions. Medical examination showed reduced deep tendon reflexes in his extremities on both the healthy and hemiplegic sides. Nerve conduction studies showed delayed conduction at the bilateral carpal and cubital tunnels and near the right caput fibulae. Genetic analysis revealed loss of a copy of the PMP22 gene. Thus, he was diagnosed with a cerebral infarction complicated by hereditary neuropathy with liability to pressure palsies. Stroke patients develop sudden muscle weakness and sensory disturbance. However, if such patients have no hyperactive deep tendon reflexes and show atypical recovery of paralysis that does not correspond to findings of imaging modalities, nerve conduction studies and genetic analysis may be necessary, considering the complication of hereditary neuropathy with liability to pressure palsies. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/27080157/A_Case_of_Apoplexy_Attack_Like_Neuropathy_due_to_Hereditary_Neuropathy_with_Liability_to_Pressure_Palsies_in_a_Patient_Diagnosed_with_Chronic_Cerebral_Infarction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(16)00184-1 DB - PRIME DP - Unbound Medicine ER -