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Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study.
Eur J Cancer 2016; 60:83-92EJ

Abstract

BACKGROUND

There is limited prospective data on the relationship between selenium status and the risk of head-neck cancer (HNC) and HNC subtypes (i.e., oral cavity cancer [OCC], oro-/hypopharyngeal cancer [OHPC] and laryngeal cancer [LC]). Therefore, we investigated the association between toenail selenium, reflecting long-term selenium exposure, and HNC risk within the Netherlands Cohort Study.

METHODS

At baseline, 120,852 participants completed a self-administered questionnaire about diet and other cancer risk factors and were asked to provide toenail clippings. After 20.3 years of follow-up, 294 cases of HNC (95 OCC, 62 OHPC, two oral cavity/pharynx unspecified or overlapping and 135 LC) and 2,164 subcohort members were available for case-cohort analysis using Cox proportional hazards models.

RESULTS

Toenail selenium status was statistically significantly associated with a decreased risk of HNC overall (multivariate RR for quartile four versus one: 0.55, 95% confidence interval [CI] 0.37-0.82, P trend = 0.001). The association between toenail selenium and risk of HNC overall was stronger among men than women, but no statistically significant interaction with sex was found. Toenail selenium level was also associated with a decreased risk of all HNC subtypes, with statistically significant associations in OHPC and LC. No statistically significant interaction was found between toenail selenium level and cigarette smoking or alcohol consumption for HNC overall.

CONCLUSIONS

In this large cohort study, we found an inverse association between toenail selenium level and HNC risk. Among HNC subtypes, this association was strongest for OHPC and LC. Furthermore, the association of toenail selenium status with HNC risk was stronger among men than women.

Authors+Show Affiliations

Department of Epidemiology, GROW - School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands.Department of Otorhinolaryngology, Head & Neck Surgery, GROW - School for Oncology & Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology & Developmental Biology, Maastricht University, Maastricht, The Netherlands. Electronic address: pa.vandenbrandt@maastrichtuniversity.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

27082137

Citation

Maasland, Denise H E., et al. "Toenail Selenium Status and Risk of Subtypes of Head-neck Cancer: the Netherlands Cohort Study." European Journal of Cancer (Oxford, England : 1990), vol. 60, 2016, pp. 83-92.
Maasland DH, Schouten LJ, Kremer B, et al. Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study. Eur J Cancer. 2016;60:83-92.
Maasland, D. H., Schouten, L. J., Kremer, B., & van den Brandt, P. A. (2016). Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study. European Journal of Cancer (Oxford, England : 1990), 60, pp. 83-92. doi:10.1016/j.ejca.2016.03.003.
Maasland DH, et al. Toenail Selenium Status and Risk of Subtypes of Head-neck Cancer: the Netherlands Cohort Study. Eur J Cancer. 2016;60:83-92. PubMed PMID: 27082137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toenail selenium status and risk of subtypes of head-neck cancer: The Netherlands Cohort Study. AU - Maasland,Denise H E, AU - Schouten,Leo J, AU - Kremer,Bernd, AU - van den Brandt,Piet A, Y1 - 2016/04/13/ PY - 2015/01/08/received PY - 2016/02/26/revised PY - 2016/03/02/accepted PY - 2016/4/16/entrez PY - 2016/4/16/pubmed PY - 2017/7/4/medline KW - Aetiology KW - Cohort studies KW - Head-neck cancer KW - Laryngeal cancer KW - Oral cavity cancer KW - Oro-/hypopharyngeal cancer KW - Prospective studies KW - Selenium KW - Toenail selenium SP - 83 EP - 92 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 60 N2 - BACKGROUND: There is limited prospective data on the relationship between selenium status and the risk of head-neck cancer (HNC) and HNC subtypes (i.e., oral cavity cancer [OCC], oro-/hypopharyngeal cancer [OHPC] and laryngeal cancer [LC]). Therefore, we investigated the association between toenail selenium, reflecting long-term selenium exposure, and HNC risk within the Netherlands Cohort Study. METHODS: At baseline, 120,852 participants completed a self-administered questionnaire about diet and other cancer risk factors and were asked to provide toenail clippings. After 20.3 years of follow-up, 294 cases of HNC (95 OCC, 62 OHPC, two oral cavity/pharynx unspecified or overlapping and 135 LC) and 2,164 subcohort members were available for case-cohort analysis using Cox proportional hazards models. RESULTS: Toenail selenium status was statistically significantly associated with a decreased risk of HNC overall (multivariate RR for quartile four versus one: 0.55, 95% confidence interval [CI] 0.37-0.82, P trend = 0.001). The association between toenail selenium and risk of HNC overall was stronger among men than women, but no statistically significant interaction with sex was found. Toenail selenium level was also associated with a decreased risk of all HNC subtypes, with statistically significant associations in OHPC and LC. No statistically significant interaction was found between toenail selenium level and cigarette smoking or alcohol consumption for HNC overall. CONCLUSIONS: In this large cohort study, we found an inverse association between toenail selenium level and HNC risk. Among HNC subtypes, this association was strongest for OHPC and LC. Furthermore, the association of toenail selenium status with HNC risk was stronger among men than women. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/27082137/Toenail_selenium_status_and_risk_of_subtypes_of_head_neck_cancer:_The_Netherlands_Cohort_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(16)00158-1 DB - PRIME DP - Unbound Medicine ER -