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Macular Structure and Function in Nonhuman Primate Experimental Glaucoma.
Invest Ophthalmol Vis Sci. 2016 Apr; 57(4):1892-900.IO

Abstract

PURPOSE

To evaluate structure and function of macular retinal layers in nonhuman primate (NHP) experimental glaucoma (EG).

METHODS

Twenty-one NHP had longitudinal imaging of macular structure by SDOCT, 16 also had recordings of function by multifocal ERG. The average thickness over 15° was derived for seven individual SDOCT layers: macular nerve fiber layer (m-NFL), retinal ganglion cell layer (RGCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer+inner segments combined (ONL+IS), and outer segments (OS). Peripapillary RNFL thickness (ppRNFLT) was measured from a single circular B-scan with 12° diameter. Responses to a slow-sequence multifocal ERG (mfERG) stimulus (7F) were filtered (at 75 Hz) into low- and high-frequency components (LFC, HFC).

RESULTS

At final follow-up, significant structural loss occurred only in EG eyes and only for ppRNFLT (-29 ± 23%), m-NFL (-17 ± 16%), RGCL (-22 ± 15%), and IPL (-19 ± 14%); though there was also a small increase in OPL (+6 ± 7%) and ONL+IS (4 ± 4%) and a similar tendency for INL. Macular structural loss was correlated with ppRNFLT only for the NFL, RGCL and IPL (R = 0.95, 0.93 and 0.95, respectively, P < 0.0001). Significant functional loss occurred only for HFC and N2 in EG eyes. Significant longitudinal structure-function correlations (P < 0.01) were observed only in EG eyes and only for mfERG HFC and N2: HFC was correlated with ppRNFLT (R = 0.69), macular NFL (R = 0.67), RGCL (R = 0.74), and IPL (R = 0.72); N2 was correlated with RGCL (R = 0.54) and IPL (R = 0.48). High-frequency components amplitude change was inversely correlated with outer retinal thickness change (= -0.66).

CONCLUSIONS

Macular structural and functional losses are correlated and specific to ganglion cells over a wide range of EG severity. Outer retinal changes are likely due to inner retinal loss.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

27082305

Citation

Wilsey, Laura J., et al. "Macular Structure and Function in Nonhuman Primate Experimental Glaucoma." Investigative Ophthalmology & Visual Science, vol. 57, no. 4, 2016, pp. 1892-900.
Wilsey LJ, Reynaud J, Cull G, et al. Macular Structure and Function in Nonhuman Primate Experimental Glaucoma. Invest Ophthalmol Vis Sci. 2016;57(4):1892-900.
Wilsey, L. J., Reynaud, J., Cull, G., Burgoyne, C. F., & Fortune, B. (2016). Macular Structure and Function in Nonhuman Primate Experimental Glaucoma. Investigative Ophthalmology & Visual Science, 57(4), 1892-900. https://doi.org/10.1167/iovs.15-18119
Wilsey LJ, et al. Macular Structure and Function in Nonhuman Primate Experimental Glaucoma. Invest Ophthalmol Vis Sci. 2016;57(4):1892-900. PubMed PMID: 27082305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular Structure and Function in Nonhuman Primate Experimental Glaucoma. AU - Wilsey,Laura J, AU - Reynaud,Juan, AU - Cull,Grant, AU - Burgoyne,Claude F, AU - Fortune,Brad, PY - 2016/4/16/entrez PY - 2016/4/16/pubmed PY - 2016/8/24/medline SP - 1892 EP - 900 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 57 IS - 4 N2 - PURPOSE: To evaluate structure and function of macular retinal layers in nonhuman primate (NHP) experimental glaucoma (EG). METHODS: Twenty-one NHP had longitudinal imaging of macular structure by SDOCT, 16 also had recordings of function by multifocal ERG. The average thickness over 15° was derived for seven individual SDOCT layers: macular nerve fiber layer (m-NFL), retinal ganglion cell layer (RGCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer+inner segments combined (ONL+IS), and outer segments (OS). Peripapillary RNFL thickness (ppRNFLT) was measured from a single circular B-scan with 12° diameter. Responses to a slow-sequence multifocal ERG (mfERG) stimulus (7F) were filtered (at 75 Hz) into low- and high-frequency components (LFC, HFC). RESULTS: At final follow-up, significant structural loss occurred only in EG eyes and only for ppRNFLT (-29 ± 23%), m-NFL (-17 ± 16%), RGCL (-22 ± 15%), and IPL (-19 ± 14%); though there was also a small increase in OPL (+6 ± 7%) and ONL+IS (4 ± 4%) and a similar tendency for INL. Macular structural loss was correlated with ppRNFLT only for the NFL, RGCL and IPL (R = 0.95, 0.93 and 0.95, respectively, P < 0.0001). Significant functional loss occurred only for HFC and N2 in EG eyes. Significant longitudinal structure-function correlations (P < 0.01) were observed only in EG eyes and only for mfERG HFC and N2: HFC was correlated with ppRNFLT (R = 0.69), macular NFL (R = 0.67), RGCL (R = 0.74), and IPL (R = 0.72); N2 was correlated with RGCL (R = 0.54) and IPL (R = 0.48). High-frequency components amplitude change was inversely correlated with outer retinal thickness change (= -0.66). CONCLUSIONS: Macular structural and functional losses are correlated and specific to ganglion cells over a wide range of EG severity. Outer retinal changes are likely due to inner retinal loss. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/27082305/Macular_Structure_and_Function_in_Nonhuman_Primate_Experimental_Glaucoma_ DB - PRIME DP - Unbound Medicine ER -